ITC References beta

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.
Pellegrini, E. et al. Structure (2016)

Discovery of novel oral protein synthesis inhibitors of Mycobacterium tuberculosis that target leucyl-tRNA synthetase.
Palencia, A. et al. Antimicrob Agents Chemother. (2016)

Cryptosporidium and Toxoplasma parasites are inhibited by a benzoxaborole targeting leucyl-tRNA synthetase.
Palencia, A. et al. Antimicrob Agents Chemother. (2016)

Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.
Zhao, H. et al. ACS Chem. Biol. (2015)

Structure and dynamics of the MKK7–JNK signaling complex.
Kragelj, J. et al. PNAS (2015)

Biochemical and biophysical characterization of the Selenium binding and reducing site in Arabidopsis thaliana homologue to mammals Selenium Binding Protein 1.
Schild, F. et al. J Biol Chem (2014)

The physiological target for LeuRS translational quality control is norvaline.
Cvetešić, N. et al. EMBO J (2014)

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.
Dias, J. et al. Genes Dev (2014)

Crystal structure of mouse mu-crystallin complexed with NADPH and the T3 thyroid hormone.
Borel, F. et al. FEBS J. (2014)

Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.
Wu, H. et al. Cell Rep (2013)

The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains.
Benoit, M.P. et al. Nucleic Acids Res (2013)

Plant tumour biocontrol agent employs a tRNA-dependent mechanism to inhibit leucyl-tRNA synthetase.
Chopra, S. et al. Nat Commun (2013)

Analysis of interactions by calorimetry (ITC)

ITC is the most precise technique to measure the affinity between macromolecules such as proteins, nucleic acids, or any small molecule.