{"id":9428,"date":"2017-03-13T15:15:59","date_gmt":"2017-03-13T14:15:59","guid":{"rendered":"https:\/\/news.embl.de\/?p=9428"},"modified":"2024-03-22T13:39:46","modified_gmt":"2024-03-22T12:39:46","slug":"futures-understanding-gene-regulation","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/futures-understanding-gene-regulation\/","title":{"rendered":"Futures: Genome regulation"},"content":{"rendered":"\n<div class=\"wp-block-image size-full wp-image-9444 vf-u-width__30\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-inline-start  \"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/03\/furlong_eileen_2014-150x150.jpg\" alt=\"\" class=\"wp-image-9444\"\/><figcaption class=\"vf-figure__caption\">Eileen Furlong, head of the <a href=\"http:\/\/www.embl.de\/research\/units\/genome_biology\/index.html\">Genome Biology Unit<\/a> at EMBL&#8217;s Heidelberg site. PHOTO: EMBL<\/figcaption><\/figure><\/div>\n\n\n\n<p>I\u2019m fascinated by the question of how the genome is regulated in a developing embryo. We know that a large part of our genome is involved in regulating gene activity, and differences in this activity are crucial in determining the way cells develop into different cell types, ultimately forming the diverse range of tissues in our body. It\u2019s a complex process but errors are surprisingly rare, so we\u2019d like to understand how this regulation of embryonic genes can be so precise.<\/p>\n\n\n\n<p>To understand genome regulation, we need to study the three-dimensional arrangement of regulatory elements and genes within the nucleus of the cell. At present, the two main methods for doing that are genomics and microscopy. With genomics techniques, it\u2019s possible to survey the entire genome at a very high molecular resolution, but most of the time you can only measure things in bulk, averaged over thousands or millions of cells. Using light microscopy you can look at a single cell and observe the dynamics of these processes, but you can only study a few regions of the genome at a time and only ones that are spaced far enough apart in the nucleus. Over the next five years, as microscopes reach higher resolution and genomics moves to single-cell methods for studying genome regulation, these two views will merge. It would be really exciting to get to a point where we could observe the regulation of individual genes live in a developing embryo.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>We&#8217;d like to understand how this regulation can be so precise<\/p><\/blockquote>\n\n\n\n<p>Computer modelling is also important, as it allows us to test whether we have an accurate picture of all the regulatory steps occurring in the embryo, or whether there are aspects we have missed. Ultimately I\u2019d like to be able to model the whole process of genome regulation and gene expression. We don\u2019t know if that\u2019s possible yet, but in ten years I hope we\u2019ll have an answer.<\/p>\n\n\n<div class=\"vf-box vf-box--normal vf-box-theme--primary\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" size-full=\"\" wp-image-9449=\"\" alignleft\"=\"\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/03\/erc-logo150x150.jpg\" alt=\"\"\/>\n<p class=\"vf-box__text\">The European Research Council (ERC) is a European funding body that offers substantial five-year grants to support researchers at all stages of their careers. Inspired by&nbsp;the ERC\u2019s tenth anniversary in 2017, we asked some of EMBL\u2019s ERC grantees to look ahead another ten years and share their vision for their field of research.<\/p>\n<p class=\"vf-box__text\" class=\"p1\"><a href=\"http:\/\/www.embl.de\/research\/faculty\/erc-investigators\/\">Find out more about EMBL&#8217;s ERC grantees<\/a>.<\/p>\n<p class=\"vf-box__text\" class=\"p1\"><a href=\"https:\/\/news.embl.de\/tag\/futures\/?_ga=1.233145306.592483598.1486366032\">More&nbsp;articles in EMBL&#8217;s&nbsp;Futures&nbsp;series<\/a>.<\/p>\n<p class=\"vf-box__text\" class=\"p1\"><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ERC grantee Eileen Furlong shares her vision for the next ten years<\/p>\n","protected":false},"author":45,"featured_media":9448,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[64,189,55,484,495,183,40,42,43,79,491],"embl_taxonomy":[],"class_list":["post-9428","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-biology","tag-computational-biology","tag-development","tag-furlong","tag-future","tag-gene-expression","tag-gene-regulation","tag-genomics","tag-heidelberg","tag-microscopy","tag-single-cell-genomics"],"acf":{"article_intro":"<p>As part of a series marking the tenth anniversary of the European Research Council, ERC grantee\u00a0Eileen Furlong\u00a0shares her\u00a0vision for the next ten years<\/p>\n","related_links":[{"link_description":"","link_url":""},{"link_description":"","link_url":""}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53","show_featured_image":false,"field_target_display":"embl","source_article":false,"in_this_article":false,"press_contact":"None"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Futures: Genome regulation | EMBL<\/title>\n<meta name=\"description\" content=\"As part of a series marking the tenth anniversary of the European Research Council, ERC grantee Eileen Furlong shares her vision for the next ten years\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/futures-understanding-gene-regulation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Futures: Genome regulation | EMBL\" \/>\n<meta property=\"og:description\" content=\"As part of a series marking the tenth anniversary of the European Research Council, ERC grantee Eileen Furlong shares her vision for the next ten years\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/futures-understanding-gene-regulation\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-03-13T14:15:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T12:39:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/03\/drosophila-small2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Edward Dadswell\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Edward Dadswell\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/futures-understanding-gene-regulation\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/futures-understanding-gene-regulation\/\"},\"author\":{\"name\":\"Edward 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