{"id":9387,"date":"2017-03-13T15:16:25","date_gmt":"2017-03-13T14:16:25","guid":{"rendered":"https:\/\/news.embl.de\/?p=9387"},"modified":"2024-03-22T13:39:42","modified_gmt":"2024-03-22T12:39:42","slug":"futures-understanding-brain-evolution","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/futures-understanding-brain-evolution\/","title":{"rendered":"Futures: Brain evolution"},"content":{"rendered":"\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   wp-image-9440 size-full vf-u-width__30 is-style-default\"><a href=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/03\/Detlev-Arendt_P88A0756-150x150.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/03\/Detlev-Arendt_P88A0756-150x150.jpg\" alt=\"Profile photo of Detlev Arendt.\" class=\"wp-image-9440\"\/><\/a><figcaption class=\"vf-figure__caption\">Detlev Arendt<\/figcaption><\/figure>\n\n\n\n<p>I want to know how the brain evolved. It\u2019s a process that can be traced back to simple organisms like sponges, which don\u2019t have a nervous system but \u2013 intriguingly \u2013 have many of the components for building one. From those beginnings, how did we end up with the network of billions of neurons that make up the human brain? It\u2019s a question we\u2019ll never be able to answer by looking at fossils, because it\u2019s extremely rare for any trace of the nervous system to be preserved.<\/p>\n\n\n\n<p>We\u2019re now starting to explore this problem at the single-cell level. This is important because even small parts of the brain can contain many different cell types. If you\u2019re taking measurements of a large group of cells, you can\u2019t see what each cell type is doing. By going down to the single-cell level, we\u2019re rephrasing the question of how brains evolved and asking instead how the different types of neuron evolved that make up the brain. What was the first neuron? What did it look like? What did it do? We study many types of organism, including sponges, sea anemones, annelids (segmented worms), and lancelets (fish-like animals without a backbone). By comparing species, we can identify the molecular building blocks and cell types that must have been present in their last common ancestor. Gradually we build up a picture of what existed at a particular point in the evolutionary tree. It\u2019s a gigantic puzzle but it\u2019s no longer science fiction to think we can work this out.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\">\n<p>It&#8217;s no longer science fiction to think we can work this out<\/p>\n<\/blockquote>\n\n\n\n<p>One thing I\u2019d like to see developed is single-cell proteomics \u2013 the ability to identify all the proteins in a particular cell. We can identify which genes are active, but not all of those genes will be translated to make proteins. Proteins also come together to build complex molecular machines, so it would be much easier to understand a cell\u2019s function if we knew which proteins and protein complexes were specific to that cell.<\/p>\n\n\n\n<p>We\u2019re now beginning to see the logic of brain evolution. We can already sketch the process, and it\u2019s feasible that we\u2019ll have a complete picture in the next ten years.<\/p>\n\n\n<div class=\"vf-box vf-box--normal vf-box-theme--primary\"><br \/>\n<img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9449 alignleft\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/03\/erc-logo150x150.jpg\" alt=\"\" width=\"150\" height=\"150\" \/>\n<p class=\"vf-box__text\">The European Research Council (ERC) is a European funding body that offers substantial five-year grants to support researchers at all stages of their careers. Inspired by\u00a0the ERC\u2019s tenth anniversary in 2017, we asked some of EMBL\u2019s ERC grantees to look ahead another ten years and share their vision for their field of research.<\/p>\n<p class=\"vf-box__text\" class=\"p1\"><a href=\"http:\/\/www.embl.de\/research\/faculty\/erc-investigators\/\">Find out more about EMBL&#8217;s ERC grantees<\/a>.<\/p>\n<p class=\"vf-box__text\" class=\"p1\"><a href=\"https:\/\/news.embl.de\/tag\/futures\/?_ga=1.233145306.592483598.1486366032\">More\u00a0articles in EMBL&#8217;s\u00a0Futures\u00a0series<\/a>.<\/p>\n<p class=\"vf-box__text\" class=\"p1\"><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ERC grantee Detlev Arendt shares his vision for the next ten years<\/p>\n","protected":false},"author":45,"featured_media":9439,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[417,64,55,31,495,43,184,67,45,491,17333],"embl_taxonomy":[],"class_list":["post-9387","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-arendt","tag-cell-biology","tag-development","tag-evolution","tag-future","tag-heidelberg","tag-model-organism","tag-neurobiology","tag-proteomics","tag-single-cell-genomics","tag-sponge"],"acf":{"article_intro":"<p>As part of a series marking the tenth anniversary of the European Research Council, ERC grantee Detlev Arendt shares his\u00a0vision for the next ten years<\/p>\n","related_links":[{"link_description":"","link_url":""},{"link_description":"","link_url":""}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53","show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":""},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Futures: Brain evolution | EMBL<\/title>\n<meta name=\"description\" content=\"As part of a series marking the tenth anniversary of the European Research Council, ERC grantee Detlev Arendt shares his vision for the next ten years\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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