{"id":9379,"date":"2017-03-09T15:34:11","date_gmt":"2017-03-09T14:34:11","guid":{"rendered":"https:\/\/news.embl.de\/?p=9379"},"modified":"2024-03-22T13:39:50","modified_gmt":"2024-03-22T12:39:50","slug":"cell-division-offers-hope-fighting-antibiotic-resistance","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/","title":{"rendered":"Cell division offers hope to fight antibiotic resistance"},"content":{"rendered":"\n<p>Growing levels of antibiotic resistance pose a serious threat to global public health and scientists are racing to find novel ways to tackle bacterial infections. EMBL\u2019s Orsolya Barabas explains a recent study by <a href=\"https:\/\/www.embl.de\/research\/units\/scb\/barabas\/index.html\">her lab<\/a> on how bacteria untangle their chromosomes during division, and the hope that this opens for developing new antibacterial treatments.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">&nbsp;What did you find?<\/h2>\n\n\n\n<p>A bacterium\u2019s DNA is in a ring-shaped chromosome. When the bacterium divides to produce two daughter cells, the DNA has to be repackaged into two rings, one for each new cell. The DNA in the two daughter rings often gets tangled. If those chromosome rings cannot be untangled, the two daughter cells cannot separate from each other and the bacteria will ultimately die.<\/p>\n\n\n\n<div class=\"wp-block-image size-full wp-image-9383\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-centered \"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"196\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2017\/03\/1703_bacterial-chromosomes_02.jpg\" alt=\"\" class=\"wp-image-9383\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/03\/1703_bacterial-chromosomes_02.jpg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/03\/1703_bacterial-chromosomes_02-300x95.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">When a bacterium divides to produce two daughter cells, the DNA in the two daughter rings often gets tangled. IMAGE: Orsolya Barabas\/EMBL<\/figcaption><\/figure><\/div>\n\n\n\n<p>Most bacteria have a protein that cuts any DNA tangled during cell division and sticks it back together as two distinct daughter chromosomes. We discovered that this protein doesn\u2019t start cutting as soon as it binds to DNA. First, another protein has to activate it by changing its shape. This means one could look at designing drugs to interfere with that activation process. And that\u2019s really good news because the alternative \u2013 preventing proteins from binding to DNA \u2013 is very difficult.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">&nbsp;Why is it important?<\/h2>\n\n\n\n<p>At the moment, it seems like for every antibiotic we have, there\u2019s at least one bacterium that\u2019s resistant to it. This means common infectious diseases are getting harder to treat and procedures that we routinely use today such as organ transplants, chemotherapy, surgery and diabetes management could become very risky. If we\u2019re going to overcome that, we need to look at new ways of fighting bacterial infections. Preventing the untangling of chromosomes during bacterial cell division could be one option. The untangling seems to work in a similar way in most types of bacteria, although the proteins are slightly different from one species to another. So with the knowledge that we\u2019ve acquired in this study, we could either look at developing generic drugs that would target all bacteria equally, or we could also envision going for a specific therapy for specific bacteria.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Keeping bacterial chromosomes tangled could lead to new approaches to treatment<\/p>\n","protected":false},"author":8,"featured_media":9382,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[494,32,43,35],"embl_taxonomy":[],"class_list":["post-9379","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-antibiotic-resistance","tag-health","tag-heidelberg","tag-structural-biology"],"acf":{"article_intro":"<p>Keeping bacterial chromosomes tangled could offer hope in developing novel approaches to treating bacterial infections<\/p>\n","related_links":[{"link_description":"Barabas lab | EMBL","link_url":"https:\/\/www.embl.de\/research\/units\/scb\/barabas\/index.html"},{"link_description":"WHO factsheet: antimicrobial resistance","link_url":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs194\/en\/"}],"article_sources":[{"source_description":"<p>Bebel A <em>et al.<\/em> <em>eLife<\/em>, 23 December 2016. DOI: 10.7554\/eLife.19706<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.7554\/eLife.19706"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cell division offers hope in fighting antibiotic resistance | EMBL<\/title>\n<meta name=\"description\" content=\"Keeping bacterial chromosomes tangled could offer hope of new treatments for bacterial infections; overcoming antibiotic resistance, say EMBL scientists\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell division offers hope in fighting antibiotic resistance | EMBL\" \/>\n<meta property=\"og:description\" content=\"Keeping bacterial chromosomes tangled could offer hope of new treatments for bacterial infections; overcoming antibiotic resistance, say EMBL scientists\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2017-03-09T14:34:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T12:39:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/03\/Helicobacterpylori_AJC1_CCBYSA20_ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sonia Furtado Neves\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Aur_ora\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sonia Furtado Neves\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/\"},\"author\":{\"name\":\"Sonia Furtado Neves\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68\"},\"headline\":\"Cell division offers hope to fight antibiotic resistance\",\"datePublished\":\"2017-03-09T14:34:11+00:00\",\"dateModified\":\"2024-03-22T12:39:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/\"},\"wordCount\":388,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/cell-division-offers-hope-fighting-antibiotic-resistance\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2017\/03\/Helicobacterpylori_AJC1_CCBYSA20_ib.jpg\",\"keywords\":[\"antibiotic resistance\",\"health\",\"heidelberg\",\"structural biology\"],\"articleSection\":[\"Science\",\"Science &amp; 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