{"id":9069,"date":"2017-01-26T12:51:16","date_gmt":"2017-01-26T11:51:16","guid":{"rendered":"https:\/\/news.embl.de\/?p=9069"},"modified":"2024-03-22T13:33:30","modified_gmt":"2024-03-22T12:33:30","slug":"1701-social-genetic-effects-health","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1701-social-genetic-effects-health\/","title":{"rendered":"Genetics of \u2018room-mate\u2019 influences health"},"content":{"rendered":"\n<p>Researchers at the European Bioinformatics Institute (EMBL-EBI) have shown that the health of individual mice is influenced by the genetic makeup of their partners. Their work on social genetic effects, <a href=\"http:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1006498\">published in PLOS Genetics<\/a>, indicates that research into genetics and disease should include the genotypes of both individuals and their partners.<\/p>\n\n\n<div class=\"vf-box vf-box--normal vf-box-theme--primary\">\n<h2 class=\"vf-box__heading\">Summary<\/h2>\n<ul>\n<li>For the first time, research in mice shows that the genetic makeup of an individual\u2019s social partners contributes to their state of health.<\/li>\n<li>Unexpectedly, the genetics of social partners were found to affect wound healing and body weight as well as behaviour.<\/li>\n<li>The methods used to detect \u2018social genetic effects\u2019 help future research into the mechanisms whereby one individual influences another.<\/li>\n<li>Findings underscore that research into the genetics of disease should include both individuals and their partners.<\/li>\n<\/ul>\n<p class=\"vf-box__text\"><\/p><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Background<\/h2>\n\n\n\n<p>Most traits are genetically controlled to some extent, for example, one\u2019s sleep preferences have a genetic component. But nothing happens in isolation.&nbsp;If your partner is a night owl and keeps you awake later than you\u2019d like, their genotypes might be partly to blame.<\/p>\n\n\n\n<p>\u201cPeople influence your behaviour, health and wellbeing, and you influence theirs \u2013 this much we know already. What\u2019s been missing is recognition that there is a genetic basis for this,\u201d explains Amelie Baud of EMBL-EBI, who led the study. \u201cIf you\u2019re a researcher looking for links between genotypes and disease, it is very important to look not only at your patient but also at their social environment.\u201d<\/p>\n\n\n\n<p>Research into \u2018social genetic effects\u2019 can help patients and doctors identify the best way to intervene when a patient\u2019s health is affected by their partner.<\/p>\n\n\n\n<p>\u201cPeople choose each other, and know they influence one another,\u201d Baud continues. \u201cBut often they are not aware of how this works.\u201d<\/p>\n\n\n\n<div class=\"vf-video\" style=\"padding-top: 0; padding-bottom: 56.25%;\">\n    <iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/youtube.com\/embed\/3YkiiroIhnY\" frameborder=\"0\" allow=\"autoplay; encrypted-media\" allowfullscreen><\/iframe>\n<\/div>\n\n\n\n<p>Research on social genetic effects can uncover the biological mechanisms that determine how individuals influence one another. The influence of a social partner can be mediated by so many traits that it would be unrealistic to measure them all. By contrast, measuring the genotypes of a patient\u2019s partner is straightforward and can reveal important drivers.<\/p>\n\n\n\n<p>\u201cImagine you are a morning person and your partner is a night owl. So every night you end up going to sleep later than you\u2019d like,\u201d explains Baud. \u201cNow, say you develop an illness, but don\u2019t mention the sleep situation to your doctor because you don\u2019t know that it\u2019s important. Maybe your doctor doesn\u2019t ask you because she doesn\u2019t know it\u2019s relevant. But if research showed there was indeed a connection between your illness and the genes that control your partner\u2019s sleeping pattern, then your doctor could better probe your life habits and give useful advice. You and your night owl could then make the right change to ensure you get the sleep you need to heal. With this change, you would be mitigating the negative influence of the night owl\u2019s genotypes on your health.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What they found<\/h2>\n\n\n\n<p>In this study, the researchers used two strains of mice, grey and black, and set them up as unrelated \u2018roommates\u2019 in different combinations. They studied social genetic effects by measuring associations between traits such as wound healing, body weight, anxiety and depressed mood in individual mice and the genetic makeup (strain) of their cage mates.<\/p>\n\n\n\n<p>\u201cYou can detect social genetic effects even if you don\u2019t know the specific traits that mediate how an individual is influenced by their social environment,\u201d says Baud. \u201cWe only measured traits like healing, anxiety and body weight in mice and genotypes in their cage mates. We found a surprisingly high contribution of the strain of the cage mates to variation in these measures.\u201d<\/p>\n\n\n\n<p>The researchers also re-analysed an existing dataset from 2500 genetically unique mice to investigate more health-related traits, studying a population that is genetically more similar to the human population. They found that social genetic effects explained up to 29% of phenotypic variance in the traits measured.<\/p>\n\n\n\n<p>The team found that the traits most affected were wound healing, anxiety, immune function, and body weight. In some cases, the contribution of social genetic effects exceeded that of direct genetic effects (i.e. the effect of an individual\u2019s own genotypes on these traits).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why it matters<\/h2>\n\n\n\n<p>\u201cAlthough today\u2019s study was carried out in mice living together, it provides food for thought about how individuals can be influenced by the genetic makeup of the people in their lives &#8211; and vice versa. The methods and approaches we developed could certainly be applied to human studies,\u201d says Oliver Stegle of EMBL-EBI.<\/p>\n\n\n\n<p>By studying social genetic effects, the researchers hope to learn more about the mechanisms whereby people influence one another.<\/p>\n\n\n\n<p>\u201cAs a geneticist I want to provide doctors with information to understand the mechanisms and causal pathways behind a disease, so they have a better idea of how to intervene to help their patient heal,\u201d says Baud. \u201cOur goal is to include the full genetic ecosystem to understand how we influence one another.\u201d<\/p>\n\n\n\n<p>&#8211; Ends &#8211;<\/p>\n\n\n\n<p>This post was originally published on <a href=\"https:\/\/www.ebi.ac.uk\/about\/news\/press-releases\/roommate-genes-affect-health\" target=\"_blank\" rel=\"canonical nofollow noopener noreferrer\" data-href=\"https:\/\/www.ebi.ac.uk\/about\/news\/press-releases\/roommate-genes-affect-health\">EMBL-EBI News<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Healing and anxiety are influenced by the genetics of one\u2019s social partners<\/p>\n","protected":false},"author":13,"featured_media":9072,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[183,41,486],"embl_taxonomy":[],"class_list":["post-9069","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-gene-expression","tag-genetics","tag-social-genetic-effects"],"acf":{"article_intro":"<p>Healing and anxiety are influenced by the genetics of one\u2019s social partners, according to new research from EMBL-EBI.<\/p>\n","related_links":[{"link_description":"Stegle Group","link_url":"https:\/\/www.ebi.ac.uk\/research\/stegle"}],"article_sources":[{"source_description":"<p>Baud A <em>et al.<\/em> PLOS<em> Genetics, <\/em>published online 25 January 2017. DOI:10.1371\/journal.pgen.1006498<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.1371\/journal.pgen.1006498"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Social genetic effects: how the genes of our social partners affect our health<\/title>\n<meta name=\"description\" content=\"EMBL-EBI researcher Amelie Baud explains how &#039;social genetic effects&#039; requires research to look at both the individual and their social environment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/1701-social-genetic-effects-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Social genetic effects: how the genes of our social partners affect our health\" \/>\n<meta property=\"og:description\" content=\"EMBL-EBI researcher Amelie Baud explains how &#039;social genetic effects&#039; 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