{"id":9001,"date":"2016-12-21T17:00:16","date_gmt":"2016-12-21T16:00:16","guid":{"rendered":"https:\/\/news.embl.de\/?p=9001"},"modified":"2024-03-25T10:06:31","modified_gmt":"2024-03-25T09:06:31","slug":"1612_new-insights-into-receptor-balancing","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/","title":{"rendered":"New insights into receptor balancing"},"content":{"rendered":"\n<p>Research at EMBL suggests a new mechanism for managing the number of receptors at the cell\u2019s plasma membrane. Receptors on a cell\u2019s membrane detect cues in its environment, and often carry those cues into the cell, triggering chain reactions that enable the cell to respond. For the first time, EMBL scientists have shown an inducible link between the mechanism for degrading these receptors and the process of transporting newly synthesised receptors to the cell surface, to keep the right balance. It is the balance between how many of the receptors are being made, how many are being degraded and how many that are being recycled that determine the number on the cell surface.<\/p>\n\n\n\n<p>A chance conversation got PhD student Sandra Scharaw thinking about the proteins involved in the receptor protein balance in a new way. After exposing the cells to epithelial growth factor (EGF) to induce EGF receptor signalling and as a consequence its partial degradation, Scharaw was surprised to also measure an increase in the production of EGF receptor proteins, as well as the specific machinery to transport it to the cell surface.<\/p>\n\n\n\n<p>The EGF receptor has, in team leader <a href=\"https:\/\/www.embl.de\/research\/units\/cbb\/pepperkok\/members\/index.php?s_personId=CP-60003201\">Rainer Pepperkok<\/a>\u2019s words, been \u2018studied to death\u2019, making it an ideal model to study. After revealing a mechanism to maintain EGF receptor number on the cell surface, now the group wonder if there might be other linked feedback loops, especially as the number of receptors on the cell surface also has implications in cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inducible mechanism found by EMBL scientists links receptor degradation and replenishment<\/p>\n","protected":false},"author":44,"featured_media":9005,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[43,398],"embl_taxonomy":[],"class_list":["post-9001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-heidelberg","tag-pepperkok"],"acf":{"article_intro":"<p>Inducible mechanism found by EMBL scientists links receptor degradation and replenishment<\/p>\n","related_links":[{"link_description":"Pepperkok lab website","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/pepperkok\/index.html"}],"article_sources":[{"source_description":"<p>Scharaw et al (2016) J. Cell Biol. DOI: 10.1083\/jcb.201601090<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.1083\/jcb.201601090"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New insights into receptor balancing from EMBL scientitsts<\/title>\n<meta name=\"description\" content=\"EMBL scientists have shown an inducible link between receptor degradation and the process of transporting newly synthesised receptors to the cell surface\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New insights into receptor balancing from EMBL scientitsts\" \/>\n<meta property=\"og:description\" content=\"EMBL scientists have shown an inducible link between receptor degradation and the process of transporting newly synthesised receptors to the cell surface\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2016-12-21T16:00:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-25T09:06:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/12\/1611_update_Pepperkok_feauturedimage.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"453\" \/>\n\t<meta property=\"og:image:height\" content=\"311\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Laura Howes\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Laura Howes\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/\"},\"author\":{\"name\":\"Laura Howes\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/7d5e14088f1a79e8e3564e6f712c9263\"},\"headline\":\"New insights into receptor balancing\",\"datePublished\":\"2016-12-21T16:00:16+00:00\",\"dateModified\":\"2024-03-25T09:06:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/\"},\"wordCount\":253,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1612_new-insights-into-receptor-balancing\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/12\/1611_update_Pepperkok_feauturedimage.jpg\",\"keywords\":[\"heidelberg\",\"pepperkok\"],\"articleSection\":[\"Science\",\"Science &amp; 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