{"id":73115,"date":"2025-01-27T10:09:41","date_gmt":"2025-01-27T09:09:41","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=73115"},"modified":"2025-02-10T16:36:11","modified_gmt":"2025-02-10T15:36:11","slug":"we-are-embl-timothe-cezar","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/people-perspectives\/we-are-embl-timothe-cezar\/","title":{"rendered":"We are EMBL: Timoth\u00e9 Cezard on pivoting from biology to infrastructure"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">What is your background?<\/h3>\n\n\n\n<p>I did a Bachelor\u2019s degree in biology and a Master\u2019s degree in bioinformatics. It was the early days of bioinformatics as a science, rather than as a discovery tool. I first worked in a small start-up doing applications development in France and then I moved to Canada working on next generation sequencing method development, doing mainly data investigation. Next I joined the University of Edinburgh, initially as an bioinformatician, and progressed to a lead position in clinical bioinformatics.&nbsp;<\/p>\n\n\n\n<p>During the course of my career, I migrated from being a biologist to being a bioinformatician, a developer, then building research and clinical infrastructure.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What attracted you to EMBL-EBI?<\/h3>\n\n\n\n<p>I first heard of EMBL-EBI during university, where we learned about its open data resources.&nbsp;<\/p>\n\n\n\n<p>In 2020, I joined EMBL-EBI as a Project Lead for the European Variation Archive. As an avid user of EMBL-EBI services, I was always impressed with the output of the institute, so I was curious to see how it worked behind the scenes. I also wanted to bring my expertise in infrastructure building to help deliver EMBL-EBI\u2019s mission of safely archiving the world\u2019s biological data and making it openly available to all. Discovering the faces behind the tools I had been using for years was very interesting.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What does your current role entail?&nbsp;<\/h3>\n\n\n\n<p>The <a href=\"https:\/\/www.ebi.ac.uk\/eva\/\" target=\"_blank\" rel=\"noreferrer noopener\">European Variation Archive (EVA)<\/a> is a repository of genomic variation data for all species. We archive studies generated by the scientific community, and make them freely available to all, but we also enable researchers to slice and query one or multiple datasets, and reuse data generated by others in lots of different ways, to answer new research questions. We also create our own catalogue of all the genetic variants discovered in all species.&nbsp;<\/p>\n\n\n\n<p>To be as useful as possible to our users, we also do quite a bit of outreach. The EVA is still a young resource so we focus on reaching new communities and speaking to our users to understand different submission and data reuse cases which guide the development of the EVA.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What has been your biggest achievement at EMBL-EBI?<\/h3>\n\n\n\n<p>Over the past 4-5 years, the team has worked incredibly hard to establish the EVA as the main provider of variation data for any non-human species. One of our biggest achievements has been the creation of a <a href=\"https:\/\/www.ebi.ac.uk\/eva\/?RS-Release\" target=\"_blank\" rel=\"noreferrer noopener\">large catalogue of variants<\/a> that we produce every six months, and that covers over 250 species. This is a list of all the variants that have ever been discovered, organised by species, with links to the original data where the variants were discovered. It\u2019s like a massive index that allows people to easily understand the context of variants of interest.&nbsp;<\/p>\n\n\n\n<p>Each variant is given a unique name and we are maintaining this list, which is a pretty hefty job. We work closely with our Ensembl colleagues on this, to ensure that when new versions of reference genomes become available, the data is always up to date.&nbsp;<\/p>\n\n\n\n<p>This is one of our most used products and contains data for over 200 species, and counting.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How does your team work within the wider EMBL-EBI context?<\/h3>\n\n\n\n<p>We believe it\u2019s important to link data from different resources, to give users a comprehensive and useful picture whenever possible. As such, we work closely with other teams, particularly <a href=\"https:\/\/www.ebi.ac.uk\/biosamples\/docs\" target=\"_blank\" rel=\"noreferrer noopener\">BioSamples<\/a>, <a href=\"https:\/\/www.ebi.ac.uk\/ena\/browser\/home\" target=\"_blank\" rel=\"noreferrer noopener\">ENA<\/a> and <a href=\"https:\/\/www.ensembl.org\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\">Ensembl<\/a>.&nbsp;&nbsp;<\/p>\n\n\n\n<p>The integration of the EVA tools and data with other resources is another massive achievement and something we\u2019re constantly improving, with the aim of making it easier for our users to submit, query and navigate across resources.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What do you think will be the next big discovery coming from the life sciences?<\/h3>\n\n\n\n<p>I think we\u2019re getting closer and closer to the ability to find novel, efficient drug targets based on available data. It\u2019s not an area I\u2019m particularly working with but I feel like it\u2019s the next thing that needs to happen to really show that the big data gathering endeavours are key for bringing about precision medicine.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tim Cezard talks about the importance of genetic variation data and the move from biology to infrastructure<\/p>\n","protected":false},"author":47,"featured_media":73117,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593,11054],"tags":[28,17663,782,36,12746,2056,42,14003],"embl_taxonomy":[2906,11974],"class_list":["post-73115","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","category-perspectives","tag-bioinformatics","tag-data-resources","tag-database","tag-embl-ebi","tag-fair-data","tag-genetic-variation","tag-genomics","tag-we-are-embl","embl_taxonomy-embl-ebi","embl_taxonomy-european-genome-phenome-archive-and-european-variation-archive"],"acf":{"vfwp-news_embl_taxonomy":[2906,11974],"featured":true,"show_featured_image":false,"field_target_display":"both","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>Timoth\u00e9 Cezard has been a user of EMBL-EBI\u2019s open data resources since his university days in France. When a Project Lead job came up at the European Variation Archive, he saw it as an opportunity to take a look \u2018under the bonnet\u2019.<\/p>\n","related_links":[{"link_description":"European Variation Archive","link_url":"https:\/\/www.ebi.ac.uk\/eva\/"},{"link_description":"BioSamples","link_url":"https:\/\/www.ebi.ac.uk\/biosamples\/docs"},{"link_description":"European Nucleotide Archive","link_url":"https:\/\/www.ebi.ac.uk\/ena\/browser\/home"},{"link_description":"Ensembl","link_url":"https:\/\/www.ensembl.org\/index.html"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"a99d1a7c-ca83-4c00-ab61-d082d3e41ce3\";}","parents":[],"name":["EMBL-EBI"],"slug":"embl-ebi","description":"Where &gt; All EMBL sites &gt; EMBL-EBI"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"18699e63-ed43-40c6-8d1c-203db7ed72ee\";i:2;s:36:\"6a155838-bccc-4a49-8de3-ac53ea6747b4\";}","parents":[],"name":["European Genome-Phenome Archive and European Variation Archive"],"slug":"european-genome-phenome-archive-and-european-variation-archive","description":"What &gt; 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