{"id":72561,"date":"2025-01-20T09:00:00","date_gmt":"2025-01-20T08:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=72561"},"modified":"2025-02-17T09:55:08","modified_gmt":"2025-02-17T08:55:08","slug":"cute-molecules-and-the-scientists-who-adore-them-sarah-gharbi","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-sarah-gharbi\/","title":{"rendered":"Cute molecules and the scientists who adore them: Sarah Gharbi"},"content":{"rendered":"\n
\n
\n

\n \n The cute side of science \n <\/path>\n <\/svg>\n <\/a>\n <\/h3>\n

Behind every discovery lies a story. Often this story is of a scientist and their passion and awe for nature\u2019s design.\r\n\r\n\r\n
 \r\n
\r\n\r\n\r\nWe’ve asked some of our scientists, from across EMBL sites, to talk about the molecules that capture their imaginations and make them smile. These stories reveal the surprising beauty, humour, and charm in the molecular structures that power life itself. We invite you to explore them and fall in love with the molecules, like these scientists have.<\/p>\n <\/div>\n<\/article>\n\n\n\n\n

\u201cLooking at proteins is like looking at clouds, the shape we see can be quite subjective. But I think we can all agree that this protein looks like a poodle! <\/p>\n\n\n\n

\u201cIt\u2019s our group\u2019s \u2018pet molecule\u2019: this poodle is a molecular complex, which comprises SidH, a toxin from Legionella pneumophila<\/em> (the body), bound to the E. coli<\/em> elongation factor protein (the head), and tRNA (the muzzle). Most other such complexes are globular, but this one has ‘legs’ and a flexible ‘tail’ like a dog, which makes it very unusual. <\/p>\n\n\n\n

\u201cThe structure of this complex was solved<\/a> by Rahul Sharma, a former postdoctoral researcher in our group, with the help of, among others, our former PhD student Simonne Griffith-Jones. I supported the study by creating cellular tools so that the researchers could study the functionality of SidH \u2013 quite a challenging task because of the toxicity of the protein. The initial idea was that SidH inhibits protein translation, but the study found no evidence of that. However, mutations in the region of SidH responsible for binding to tRNA\/elongation factor reduce the toxicity of SidH in human cells, suggesting that this region is important for the toxicity of the protein.\u201d<\/p>\n\n\n\n

<\/div>\n\n\n\n

Sarah Gharbi (France), Research Technician, Bhogaraju Group<\/a>, EMBL Grenoble<\/p>\n\n\n\n\n","protected":false},"excerpt":{"rendered":"

Sarah Gharbi, technician at EMBL Grenoble, talks about her favourite protein complex, which looks like a poodle. This is part of a series of stories about EMBL scientists and quirky, charming proteins that make them smile.<\/p>\n","protected":false},"author":104,"featured_media":72573,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593],"tags":[789,18799,37,5752,35,493],"embl_taxonomy":[19175,9792],"class_list":["post-72561","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","tag-bhogaraju","tag-cute-proteins","tag-grenoble","tag-protein-structure","tag-structural-biology","tag-women-in-science","embl_taxonomy-bhogaraju-group","embl_taxonomy-embl-grenoble"],"acf":{"vfwp-news_embl_taxonomy":[9792,19175],"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"

Sarah Gharbi, technician at EMBL Grenoble, talks about her favourite protein complex, which looks like a poodle<\/p>\n","related_links":[{"link_description":"Bhogaraju group","link_url":"https:\/\/www.embl.org\/groups\/bhogaraju\/"},{"link_description":"EMBL Grenoble","link_url":"https:\/\/www.embl.org\/sites\/grenoble\/"}],"source_article":[{"publication_title":"Structural basis for the toxicity of Legionella pneumophila effector SidH.","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41467-023-42683-8","target":"_blank"},"publication_authors":"Sharma, R., Adams, M., Griffith-Jones, S., et al.","publication_source":"Nature Communications","publication_date":"3 November 2023","publication_doi":"10.1038\/s41467-023-42683-8"}],"in_this_article":false,"press_contact":"None","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"fc528877-4017-438f-85b4-de2b54c443f1\";i:2;s:36:\"bf4c9a60-313d-45d1-aeb4-c18a81cbd4d5\";}","parents":[],"name":["Bhogaraju Group"],"slug":"bhogaraju-group","description":"What > Structural Biology (EMBL Grenoble) > Bhogaraju Group"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"8f81131e-d37c-470c-848f-618fce652295\";}","parents":[],"name":["EMBL Grenoble"],"slug":"embl-grenoble","description":"Where > All EMBL sites > EMBL Grenoble"}],"yoast_head":"\nCute molecules and the scientists who adore them: Sarah Gharbi | EMBL<\/title>\n<meta name=\"description\" content=\"Sarah Gharbi, technician at EMBL Grenoble, talks about her favourite protein complex, which looks like 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