{"id":72117,"date":"2025-01-07T10:00:00","date_gmt":"2025-01-07T09:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=72117"},"modified":"2025-02-17T09:49:10","modified_gmt":"2025-02-17T08:49:10","slug":"cute-molecules-and-the-scientists-who-adore-them-maria-costanzo","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/","title":{"rendered":"Cute molecules and the scientists who adore them: Maria Costanzo"},"content":{"rendered":"\n<article class=\"vf-card vf-card--brand vf-card--striped vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n              <a class=\"vf-card__link\" href=\"https:\/\/www.embl.org\/news\/tag\/cute-proteins\/#\">\n      The cute side of science        <svg aria-hidden=\"true\" class=\"vf-card__heading__icon | vf-icon vf-icon-arrow--inline-end\" width=\"1em\" height=\"1em\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n          <path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"currentColor\" fill-rule=\"nonzero\"><\/path>\n       <\/svg>\n        <\/a>\n          <\/h3>\n                <p class=\"vf-card__text\">Behind every discovery lies a story. Often this story is of a scientist and their passion and awe for nature\u2019s design.\r\n\r\n<br \/> &nbsp;\r\n<br \/>\r\n\r\n\r\nWe&#8217;ve asked some of our scientists, from across EMBL sites, to talk about the molecules that capture their imaginations and make them smile. These stories reveal the surprising beauty, humour, and charm in the molecular structures that power life itself. We invite you to explore them and fall in love with the molecules, like these scientists have.<\/p>\n      <\/div>\n<\/article>\n\n\n\n\n<p>\u201cMy favourite protein is called <a href=\"https:\/\/www.uniprot.org\/uniprotkb\/P46938\/entry\" target=\"_blank\" rel=\"noreferrer noopener\">YAP<\/a>. It enables the cell to read its surroundings \u2013 a bit like the cell tapping its way through darkness \u2013 which I find really fascinating!<\/p>\n\n\n\n<p>\u201cYAP receives signals via the cell\u2019s molecular \u2018gossip chain\u2019, called the Hippo pathway, in which information from the cell\u2019s surroundings is passed from one protein to another. Based on this, the cell knows whether it\u2019s in the middle of a cellular crowd or has space around it, and whether to proliferate or not.<\/p>\n\n\n\n<p>\u201cBased on these signals, YAP can pick between two options: either to enter the cell nucleus and act on various genes to trigger cell division\/differentiation, or to get degraded instead. What a tough dilemma for a protein! &#x1f609;<\/p>\n\n\n\n<p>\u201cMy first acquaintance with YAP was while studying size regulation during embryonic development, which, in certain stages, relies on YAP reading the extracellular cues and telling the cells what identity to acquire.<\/p>\n\n\n\n<p>\u201cLeaving aside the technical details, I really like the YAP&#8217;s shape as well, as it makes me think of a beating heart!\u201d<\/p>\n\n\n\n<div style=\"height:15px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Maria Costanzo (Italy), Predoctoral Fellow, <a href=\"https:\/\/www.embl.org\/groups\/ebisuya\/\">Ebisuya Group<\/a>, EMBL Barcelona<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maria Costanzo, former predoc at EMBL Barcelona, talks about YAP, her favourite protein in the shape of a heart. This is part of a series of stories about EMBL scientists and quirky, charming proteins that make them smile.<\/p>\n","protected":false},"author":96,"featured_media":72121,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593],"tags":[497,525,18799,1321,563,650,5752,493],"embl_taxonomy":[19237,9762],"class_list":["post-72117","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","tag-barcelona","tag-cell-signalling","tag-cute-proteins","tag-ebisuya","tag-embryonic-development","tag-italy","tag-protein-structure","tag-women-in-science","embl_taxonomy-ebisuya-group-visiting","embl_taxonomy-embl-barcelona"],"acf":{"vfwp-news_embl_taxonomy":[19237,9762],"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>Maria Costanzo, former predoc at EMBL Barcelona, talks about YAP, her favourite protein in the shape of a heart<\/p>\n","related_links":[{"link_description":"Cute molecules and the scientists who adore them: Sofia Rucli ","link_url":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-sofia-rucli\/"},{"link_description":"Cute molecules and the scientists who adore them: Veijo Salo ","link_url":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-veijo-salo\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"18a7a17b-e276-4afd-b0ca-8ddac1883d45\";i:2;s:36:\"8e848d63-b947-49ca-a00b-53af531ad40b\";}","parents":[],"name":["Ebisuya Group (Visiting)"],"slug":"ebisuya-group-visiting","description":"What &gt; Tissue biology and disease modelling &gt; Ebisuya Group (Visiting)"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"762176bb-d12e-4c94-8964-6dbb76e15c42\";}","parents":[],"name":["EMBL Barcelona"],"slug":"embl-barcelona","description":"Where &gt; All EMBL sites &gt; EMBL Barcelona"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cute molecules and the scientists who adore them: Maria Costanzo | EMBL<\/title>\n<meta name=\"description\" content=\"Maria Costanzo, former predoc at EMBL Barcelona, talks about YAP, her favourite protein in the shape of a heart.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cute molecules and the scientists who adore them: Maria Costanzo | EMBL\" \/>\n<meta property=\"og:description\" content=\"Maria Costanzo, former predoc at EMBL Barcelona, talks about YAP, her favourite protein in the shape of a heart.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-07T09:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-17T08:49:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/11\/20241007_CuteProt_Barcelona-1000x600-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Dorota Badowska\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@d_badowska\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dorota Badowska\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/\"},\"author\":{\"name\":\"Dorota Badowska\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/b8ae50efcd7533f0ab2ec368736b1d04\"},\"headline\":\"Cute molecules and the scientists who adore them: Maria Costanzo\",\"datePublished\":\"2025-01-07T09:00:00+00:00\",\"dateModified\":\"2025-02-17T08:49:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/\"},\"wordCount\":199,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/11\/20241007_CuteProt_Barcelona-1000x600-1.jpg\",\"keywords\":[\"barcelona\",\"cell signalling\",\"cute proteins\",\"ebisuya\",\"embryonic development\",\"italy\",\"protein structure\",\"women in science\"],\"articleSection\":[\"People &amp; 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