{"id":71853,"date":"2024-11-27T14:00:00","date_gmt":"2024-11-27T13:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=71853"},"modified":"2025-02-17T09:55:48","modified_gmt":"2025-02-17T08:55:48","slug":"cute-molecules-and-the-scientists-who-adore-them-sofia-rucli","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-sofia-rucli\/","title":{"rendered":"Cute molecules and the scientists who adore them: Sofia Rucli"},"content":{"rendered":"\n
\n
\n

\n \n The cute side of science \n <\/path>\n <\/svg>\n <\/a>\n <\/h3>\n

Behind every discovery lies a story. Often this story is of a scientist and their passion and awe for nature\u2019s design.\r\n\r\n\r\n
 \r\n
\r\n\r\n\r\nWe’ve asked some of our scientists, from across EMBL sites, to talk about the molecules that capture their imaginations and make them smile. These stories reveal the surprising beauty, humour, and charm in the molecular structures that power life itself. We invite you to explore them and fall in love with the molecules, like these scientists have.\r\n<\/p>\n <\/div>\n<\/article>\n\n\n\n\n

\u201cA protein that\u2019s special to me is O-GlcNAc transferase (OGT)<\/a>. It\u2019s the protagonist of my PhD project, during which we’ve been enemies at times and good friends at others. OGT is an enzyme that attaches a sugar molecule called O-GlcNAc to proteins. I like to picture it as a \u2018candy man\u2019 or a \u2018candy enzyme\u2019 that dispenses sweetness to cellular proteins. Without its \u2018sweet\u2019 job, the cell can\u2019t survive. What a nice metaphor for how a touch of sweetness, akin to nice gestures and kindness, is essential for thriving in everyday life!<\/p>\n\n\n\n

\u201cThe molecular structure of OGT makes me think of an elephant head. Its \u2018trunk\u2019 hugs its target before depositing its sweet group onto it.<\/p>\n\n\n\n

\u201cFun fact: recently, I discovered an Instagram account called \u2018iam_OGT\u2019. I first thought it must have been by another scientist. Then, I realised it\u2019s actually an electronic music artist. One of his songs is called \u2018Hustle & Flow\u2019, which I think perfectly describes my journey with the OGT protein. You just need to learn from the hustle and follow the flow in science, and it will pay off in the end.\u201d<\/p>\n\n\n\n

<\/div>\n\n\n\n

Sofia Rucli (Italy), Postdoctoral Fellow, Boulard Group<\/a>, EMBL Rome<\/p>\n\n\n\n\n","protected":false},"excerpt":{"rendered":"

Sofia Rucli, postdoc at EMBL Rome, talks about her relationship with the protein OGT, a molecular \u2018candy man\u2019 of the cell.<\/p>\n","protected":false},"author":96,"featured_media":71859,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17593],"tags":[545,18799,266,39,3634,650,18797,5752,514,493],"embl_taxonomy":[19183,9788],"class_list":["post-71853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-people-perspectives","tag-boulard","tag-cute-proteins","tag-enzyme","tag-epigenetics","tag-glycosylation","tag-italy","tag-posttranslational-modification","tag-protein-structure","tag-rome","tag-women-in-science","embl_taxonomy-boulard-group","embl_taxonomy-embl-rome"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"

Sofia Rucli, postdoc at EMBL Rome talks about her favourite protein OGT, the cell\u2019s \u2018candy enzyme\u2019<\/p>\n","related_links":[{"link_description":"Sweet gene regulation in the mammalian embryo","link_url":"https:\/\/www.embl.org\/news\/science-technology\/sweet-gene-regulation-in-the-mammalian-embryo\/"},{"link_description":"Cute molecules and the scientists who adore them: Veijo Salo ","link_url":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-veijo-salo\/"},{"link_description":"Cute molecules and the scientists who adore them: Maria Costanzo ","link_url":"https:\/\/www.embl.org\/news\/people-perspectives\/cute-molecules-and-the-scientists-who-adore-them-maria-costanzo\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","vfwp-news_embl_taxonomy":[9788,19183]},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"a6e35bb0-c32d-4c9b-aadb-a19b6c7b060f\";i:2;s:36:\"ab8b3518-df35-4bcc-bf75-c900199c507a\";}","parents":[],"name":["Boulard Group"],"slug":"boulard-group","description":"What > Epigenetics and neurobiology > Boulard Group"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"741d5d3d-f92f-4eb8-9195-55c96454a36b\";}","parents":[],"name":["EMBL Rome"],"slug":"embl-rome","description":"Where > All EMBL sites > EMBL Rome"}],"yoast_head":"\nCute molecules and the scientists who adore them: Sofia Rucli | EMBL<\/title>\n<meta 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