{"id":69497,"date":"2024-08-01T10:24:53","date_gmt":"2024-08-01T08:24:53","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=69497"},"modified":"2025-06-10T11:04:58","modified_gmt":"2025-06-10T09:04:58","slug":"why-clinical-trials-stop-the-role-of-genetics","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science-technology\/why-clinical-trials-stop-the-role-of-genetics\/","title":{"rendered":"Why clinical trials stop: the role of genetics"},"content":{"rendered":"\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n      Summary    <\/h3>\n                <p class=\"vf-card__text\"><ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Researchers from Open Targets and EMBL-EBI have developed a machine learning model to analyse the reasons clinical trials are halted before their scheduled endpoint.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The study identifies links between genetic evidence and trial outcome and indicates that genetic evidence halves the odds of early stoppage<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Incorporating genetic evidence in drug development can potentially reduce clinical trial failures and increase the effectiveness and safety of new therapies.<\/span><\/li>\r\n<\/ul><\/p>\n      <\/div>\n<\/article>\n\n\n\n\n<p>Failure is the most likely outcome of a clinical trial. Learning from these failures by understanding which factors maximise the chances of a successful trial would help improve the drug discovery process. However, accessing information about failed clinical trials is difficult since the drug discovery literature is biased towards publishing successful results.<\/p>\n\n\n\n<p>A representative source of trial results are stopped trials, meaning clinical trials that were halted before their scheduled endpoint. Stopped trials listed on ClinicalTrials.gov must provide a freeform text reason for the stoppage. This information is openly available and can be mined to learn which features make trials more likely to fail. This could inform future drug discovery initiatives.<\/p>\n\n\n\n<p>In a study <a href=\"https:\/\/www.nature.com\/articles\/s41588-024-01854-z\">published today in Nature Genetics<\/a>, researchers at Open Targets and EMBL\u2019s European Bioinformatics Institute (EMBL-EBI) created a machine learning approach to analyse the free-text reasons explaining why 28,842 clinical trials stopped. They then evaluated the genetic evidence underpinning the target-disease relationships in these trials. Their analysis revealed that clinical trials that stopped for negative reasons \u2013 such as safety or efficacy concerns \u2013 were less supported by genetic evidence. In fact, the study indicates that genetic evidence halves the odds of early stoppage.<\/p>\n\n\n\n<p>\u201cThe results of our analysis underscore the critical importance of integrating genetic evidence in drug development,\u201d said Olesya Razuvayevskaya, Postdoctoral Research Fellow in Natural Language Processing at Open Targets. \u201cThis potentially reduces the high rates of trial failures, leading to more effective and safe therapies and laying the groundwork to de-risk future clinical studies.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A machine-learning approach using open data&nbsp;<\/h2>\n\n\n\n<p>The model created for this work is available for download and interactive exploration, and up-to-date predictions for newer clinical studies are available through the <a href=\"http:\/\/platform.opentargets.org\">Open Targets Platform<\/a>.<\/p>\n\n\n\n<p>The team created a natural language processing model to classify the stop reasons into 17 categories. For each clinical trial, they used 13 sources of genetic evidence available in the Open Targets Platform to evaluate the strength of the association between the drug target and the disease indication.&nbsp;<\/p>\n\n\n\n<p>Overall, the analysis showed that stopped trials are more likely to fail due to early coincidental factors that aren\u2019t necessarily linked to the strength of the evidence linking the drug target to the disease. For example, over a third of trials stop due to insufficient enrollment. For the 12.7% of trials that failed because of safety or efficacy reasons, the authors found a correlation with a lack of strong genetic evidence to link the target to the disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Genetic insights behind stopped clinical trials<\/h2>\n\n\n\n<p>Almost half of the stopped trials the team looked at were cancer trials, and these were more likely to stop due to safety or side effects. The authors found several characteristics of the targets in those trials that correlated with safety issues: genetic constraint \u2013 a measure of how essential a gene is \u2013 multiple known physical interactors, and lack of tissue specificity. Analyses of these unfavourable factors could help preempt early termination due to safety or side effects, maximising the chances of a successful clinical trial.&nbsp;<\/p>\n\n\n\n<p>\u201cPrevious retrospective analyses from Open Targets found that drugs are more likely to be approved when the link between the disease and the drug target is supported by evidence from genetics and genomics studies,\u201d said David Ochoa, Open Targets Platform Coordinator. \u201cTogether with this new research, genetic support is clearly both predictive of clinical trial progression and protective of early trial stoppage. This is strong support for Open Targets\u2019 founding aim to use the information generated by genetic sequencing and genomics studies to systematically improve the selection of targets for drug development.\u201d<\/p>\n\n\n\n<p>This press release was <a href=\"https:\/\/www.opentargets.org\/news\/clinical-trial-stop-reasons-Jul24.html\">originally published on the Open Targets website<\/a>. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.<\/p>\n","protected":false},"author":122,"featured_media":54172,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11060,17591],"tags":[28,312,36,42,604,763,539],"embl_taxonomy":[2906,11100],"class_list":["post-69497","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlights","category-science-technology","tag-bioinformatics","tag-drug-discovery","tag-embl-ebi","tag-genomics","tag-machine-learning","tag-open-targets","tag-research-highlight","embl_taxonomy-embl-ebi","embl_taxonomy-open-targets"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"both","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome<\/p>\n","related_links":[{"link_description":"The Open Targets Platform ","link_url":"https:\/\/platform.opentargets.org\/"}],"source_article":[{"publication_title":"Genetic factors associated with reasons for clinical trial stoppage","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41588-024-01854-z","target":""},"publication_authors":"Razuvayevskaya., et al ","publication_source":"Nature Genetics","publication_date":"29 July 2024","publication_doi":"10.1038\/s41588-024-01854-z"}],"in_this_article":false,"press_contact":"EMBL-EBI Generic","article_translations":false,"languages":"","vf_locked":false,"vfwp-news_embl_taxonomy":[2906,11100]},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"a99d1a7c-ca83-4c00-ab61-d082d3e41ce3\";}","parents":[],"name":["EMBL-EBI"],"slug":"embl-ebi","description":"Where &gt; 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