{"id":69169,"date":"2024-07-10T09:48:06","date_gmt":"2024-07-10T07:48:06","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=69169"},"modified":"2024-07-23T14:37:36","modified_gmt":"2024-07-23T12:37:36","slug":"proteomics-a-different-lens-for-precision-medicine","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/","title":{"rendered":"Proteomics: a different lens for precision medicine"},"content":{"rendered":"\n<p>If the genome is the blueprint for building an organism, the proteome is the construction crew along with some of the working materials. Each protein plays a role in constructing and maintaining the organism&#8217;s biological structures. By studying all the proteins in an organism, proteomics helps us understand health and disease. It\u2019s also a key discipline for making precision medicine a reality.\u00a0<\/p>\n\n\n\n<p>So why has proteomics so far been overshadowed by other fields, including genomics, and how is EMBL driving the discipline forward?\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>What is proteomics?<\/strong><\/h2>\n\n\n\n<p>The proteome is made up of all the proteins that exist in an organism at any given moment. Unlike the genome, which is relatively fixed throughout the course of an organism\u2019s life, the proteome is extremely dynamic \u2013 it changes over time and depending on physiological conditions.<\/p>\n\n\n\n<p>Proteomics uses high-throughput techniques, which perform rapid and simultaneous processing of a large number of experiments. Until the early 2000s, scientists were limited to observing a small number of proteins at a time. But the advent of mass spectrometry, in particular, has meant they can now see thousands of proteins simultaneously across dozens or even hundreds of samples. This has been a real step change, as has been the wider sharing of proteomics data.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Clinical applications of proteomics<\/strong><\/h2>\n\n\n\n<p>Proteins are the workhorses of the cell and most biological functions rely on them. They are also a good way to study phenotypes \u2013 an organism\u2019s features. Proteins provide a complementary ledger of information alongside genomics or transcriptomics.&nbsp;<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n<img decoding=\"async\" width=\"220\" height=\"220\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Juan-Vizcaino.jpg\" class=\"vf-profile__image vf-u-margin__right--600\" alt=\"\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Juan-Vizcaino.jpg 220w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Juan-Vizcaino-150x150.jpg 150w\" sizes=\"auto, (max-width: 220px) 100vw, 220px\" \/>  <div class=\"vf-blockquote-has-image\">\n    <div>\n      &#8220;If we want to understand how life works, what makes us ill, and what can help us get better, looking at the blueprint of the genome is not enough. We need different data types, and better ways of integrating them.\u201d    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n              <a href=\"https:\/\/www.ebi.ac.uk\/people\/person\/juan-vizcaino\/\" class=\"vf-blockquote_author__link\">\n      \n      <div class=\"vf-blockquote_author\">\n        Juan Antonio Vizca\u00edno, Team Leader at EMBL-EBI      <\/div>\n\n              <\/a>\n      \n      <div class=\"vf-blockquote_author__details\"><\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<p>An important application of proteomics in the clinical world is the search for biomarkers \u2013 molecules or characteristics in the body that researchers measure to provide a snapshot of health. Biomarkers are also used as an indicator for a person\u2019s risk of developing a certain disease or for how likely they are to respond to a treatment. For instance, C-reactive protein (CRP) is a biomarker for inflammation, and measuring the blood levels of CRP helps clinicians assess conditions like infections, autoimmune diseases, and cardiovascular disease risk.\u00a0\u00a0<\/p>\n\n\n\n<p>Proteomics experiments can measure levels of proteins in different physiological conditions and draw out useful biomarkers for a range of illnesses, including cancer and autoimmune diseases. For example, protein-protein signalling deregulation can lead to cancer, while protein aggregation can play a role in neurological diseases. Proteomics provides a useful lens through which researchers can detect how disease sets in at a molecular level. It also uncovers additional insights for developing new clinical interventions.\u00a0<\/p>\n\n\n\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n      What is precision medicine?    <\/h3>\n                <p class=\"vf-card__text\"><!-- wp:paragraph -->\r\n\r\nPrecision medicine, sometimes called personalised medicine, is an emerging healthcare approach which takes into account an individual\u2019s genetics, molecular profile, environment and lifestyle to predict what treatment would work best for them.\r\n\r\n<!-- \/wp:paragraph --><\/p>\n      <\/div>\n<\/article>\n\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Driving technological innovation<\/strong><\/h2>\n\n\n\n<p>Observing this ever-changing \u201cconstruction team\u201d in our cells is no easy task. Proteomics uses a wide range of highly complex technologies, many of which are available to scientists worldwide through <a href=\"https:\/\/www.embl.org\/groups\/proteomics\/\" target=\"_blank\" rel=\"noreferrer noopener\">EMBL\u2019s Proteomics Core Facility<\/a>, which supports over 700 scientific projects every year.\u00a0<\/p>\n\n\n\n<p>\u201cOver 200 scientists from institutes in 20 countries ran experiments at EMBL\u2019s Proteomics Core Facility in 2023,\u201d said <a href=\"https:\/\/www.embl.org\/people\/person\/mandy-rettel\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mandy Rettel, Operational Manager at EMBL\u2019s Proteomics Core Facility<\/a>. \u201cAlongside state-of-the-art mass spectrometry equipment and world-leading expertise, what makes this facility unique is that it\u2019s deeply embedded in the EMBL scientific environment.\u201d<\/p>\n\n\n\n<p>This in itself adds value. For example, a recent cross-EMBL collaboration brought together expertise in computational and experimental biology, machine learning, and data wrangling to shed light on a decades-old question. Protein phosphorylation is a process that can alter the structure of a protein, activating it, deactivating it, or modifying its function. Despite decades of work, the number of phosphorylation sites and knowledge about which ones are critical for life remain a mystery. In a collaboration that spanned three of the six EMBL sites, scientists <a href=\"https:\/\/www.ebi.ac.uk\/about\/news\/research-highlights\/phosphoproteome-machine-learning\/\" target=\"_blank\" rel=\"noreferrer noopener\">developed the largest resource to date for identifying functionally relevant phosphosites<\/a>. This has enormous potential to improve our understanding of biological processes and disease.\u00a0<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n<img decoding=\"async\" width=\"220\" height=\"220\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Mandy-Rettel.jpg\" class=\"vf-profile__image vf-u-margin__right--600\" alt=\"\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Mandy-Rettel.jpg 220w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Mandy-Rettel-150x150.jpg 150w\" sizes=\"auto, (max-width: 220px) 100vw, 220px\" \/>  <div class=\"vf-blockquote-has-image\">\n    <div>\n      <span style=\"font-weight: 400;\">&#8220;Over 200 scientists from institutes in 20 countries ran experiments at EMBL\u2019s Proteomics Core Facility in 2023.&#8221;<\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n              <a href=\"https:\/\/www.embl.org\/people\/person\/mandy-rettel\/\" class=\"vf-blockquote_author__link\">\n      \n      <div class=\"vf-blockquote_author\">\n        Mandy Rettel, Operational Manager at EMBL\u2019s Proteomics Core Facility      <\/div>\n\n              <\/a>\n      \n      <div class=\"vf-blockquote_author__details\"><\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<p>\u201cAlthough proteomics equipment and instruments are becoming increasingly easier to use, they are still very complex in terms of the physical processes happening inside,\u201d explained <a href=\"https:\/\/www.embl.org\/people\/person\/mikhail-savitski\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mikhail Savitski, Head of the EMBL Proteomics Core Facility and Research Team Leader<\/a>. \u201cAs with all multiomics data, proteomics is difficult to understand, so we put a lot of effort into making the data easy to digest and access by our users. And then, of course, there is the data sharing side, which comes with its own challenges.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Opening up the data<\/strong><\/h2>\n\n\n\n<p>The value of scientific data lies at least partly in its reuse. By making data openly accessible, researchers enable others to re-analyse them, ask new research questions, and gain new knowledge.&nbsp;<\/p>\n\n\n\n<p>\u201cProteomics is completely different now compared to when I started my PhD,\u201d said Savitski. \u201cBack then, nobody was sharing data outside their lab, but now my group reprocesses data from other publications and often extracts insights that were previously unknown. Nobody is perfect, and when you publish data, you can\u2019t extract everything of value from them, so it\u2019s important for the community to be able to mine the data further.&nbsp;<\/p>\n\n\n\n<p>\u201cNone of this would be possible without PRIDE and the ProteomeXchange, which facilitate data sharing and access worldwide. In my view, EMBL-EBI\u2019s PRIDE data resource has been a real game-changer for proteomics and has brought the field to maturity.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Making data sharing common practice<\/strong><\/h2>\n\n\n\n<p>As proteomics technology has improved in speed and throughput, the volumes of data have also increased. Data sharing has become the norm in proteomics due to a number of factors. Firstly, proteomics is increasingly seen as important to life science data ecosystems. \u201cResearchers are realising more and more that while genomics gives you the blueprint, you need other data types to understand what is going on with the biology,\u201d said Rettel.&nbsp;<\/p>\n\n\n\n<p>Secondly, reliable data repositories are now available, enabling better proteomics data access and reuse. And finally, journals and funding agencies are pushing researchers to share their data. \u201cNowadays, it would be unthinkable to publish a proteomics paper in a top journal without making the data available, which is good news for open science,\u201d explained Savitski.&nbsp;&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Data deluge &#8211; sink or swim<\/strong><\/h2>\n\n\n\n<p>Over the last decade, EMBL\u2019s European Bioinformatics Institute (EMBL-EBI) has seen the volumes of proteomics data generated by the scientific community skyrocket. \u201cIf anyone would have told me that we would reach 50,000 proteomics datasets in less than 12 years, I would have said they were crazy,\u201d beamed <a href=\"https:\/\/www.ebi.ac.uk\/people\/person\/juan-vizcaino\/\" target=\"_blank\" rel=\"noreferrer noopener\">Juan Antonio Vizca\u00edno, Team Leader at EMBL-EBI<\/a>.<\/p>\n\n\n\n<p>EMBL-EBI\u2019s proteomics data resource called <a href=\"https:\/\/www.ebi.ac.uk\/pride\/\" target=\"_blank\" rel=\"noreferrer noopener\">PRIDE<\/a> was set up in 2004, at a time when additional information about the data from proteomics experiments was confined to the supplementary materials sections of scientific papers. Back then, there was no way to verify the claims in an article about proteomics because there was no public repository for the data, meaning experiments couldn\u2019t be replicated or verified.\u00a0<\/p>\n\n\n\n<p>It took a few years for PRIDE to mature. A major shift took place in 2012, when EMBL-EBI and collaborators set up the <a href=\"https:\/\/www.proteomexchange.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">ProteomeXchange consortium<\/a> \u2013 an international collaboration for resources that store and disseminate protein data. This was an effort to avoid duplication and make proteomics data easier to access and reanalyse. ProteomeXchange is similar in concept to the <a href=\"https:\/\/www.wwpdb.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">Worldwide Protein Data Bank<\/a> for protein structures or the <a href=\"https:\/\/insdc.org\/\" target=\"_blank\" rel=\"noreferrer noopener\">International Nucleotide Database Consortium<\/a> for nucleotide data. One key difference, however, is that in ProteomeXchange, the data are not replicated across the different member resources.\u00a0<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n<img decoding=\"async\" width=\"220\" height=\"220\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Mikhail-Savitski.jpg\" class=\"vf-profile__image vf-u-margin__right--600\" alt=\"\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Mikhail-Savitski.jpg 220w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/Mikhail-Savitski-150x150.jpg 150w\" sizes=\"auto, (max-width: 220px) 100vw, 220px\" \/>  <div class=\"vf-blockquote-has-image\">\n    <div>\n      <span style=\"font-weight: 400;\">&#8220;EMBL-EBI\u2019s PRIDE data resource has been a real game-changer for proteomics and has brought the field to maturity.\u201d<\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n              <a href=\"https:\/\/www.embl.org\/people\/person\/mikhail-savitski\/\" class=\"vf-blockquote_author__link\">\n      \n      <div class=\"vf-blockquote_author\">\n        Mikhail Savitski, Head of the EMBL Proteomics Core Facility and Research Team Leader      <\/div>\n\n              <\/a>\n      \n      <div class=\"vf-blockquote_author__details\"><\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<p>At the time of writing, the ProteomeXchange consortium has six members: PRIDE in Europe, PeptideAtlas, MassIVE and PanoramaView in the US, iProX in China and JPOST in Japan. PRIDE is the largest of these resources, hosting approximately 80% of the submitted datasets, but this may shift in the coming years, as Asian countries increasingly take up data-sharing practices and mature their own resources.&nbsp;<\/p>\n\n\n\n<p>\u201cWhen we started ProteomeXchange, the number of proteomics datasets in the public domain was very small, plus they were not standardised and there was generally little appetite for data sharing among researchers,\u201d remembered Vizca\u00edno. \u201cSo we tried to encourage scientists to share data by making the submission process as straightforward as possible. The fact that in 2023, we reached over 50,000 datasets is remarkable given where we started. It\u2019s impressive to step back and look at the increase in the speed at which data is generated and shared. To give you an idea, it took the community five years to generate and share the first 10,000 datasets, and just over a year to get the most recent 10,000 datasets. That is a staggering increase!\u201d<\/p>\n\n\n\n<p>The geographic spread of the data submissions and downloads is also impressive, with datasets coming to PRIDE from over 70 countries, and ProteomeXchange resources being cited by thousands of scientific papers each year. Even more significantly, data reuse activities continue to grow in the field, involving artificial intelligence (AI) methods, metaanalysis studies, proteogenomics applications, and the development of novel analysis software, among many other applications.&nbsp;<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"332\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-Infographic-v2-1024x332.jpg\" alt=\"Graphic showing the scale of EMBL's proteomics core facility in 2023. The facility had 227 users from 20 countries. The graphic also shows that the ProteomeXchange consortium has had 50 000 datasets  submitted between 2012 and 2024, from 70 countries.\" class=\"wp-image-69171\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-Infographic-v2-1024x332.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-Infographic-v2-300x97.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-Infographic-v2-768x249.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-Infographic-v2.jpg 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Public proteomics data management is a team sport<\/strong><\/h2>\n\n\n\n<p>Openly sharing proteomics data is not always straightforward due to their volume and complexity. Sometimes data submitters require support from the PRIDE team, which only has nine staff members. The team size hasn\u2019t changed much over the years, despite the increasing volumes of data they wrangle. They have managed to keep up by automating the submission process whenever possible, although some manual intervention is still required at times.&nbsp;<\/p>\n\n\n\n<p>Made up of bioinformaticians, biologists, and software developers, the PRIDE team doesn\u2019t just manage data submissions. They also provide <a href=\"https:\/\/www.ebi.ac.uk\/training\/search-results?query=proteomics&amp;domain=ebiweb_training&amp;page=1&amp;facets=\">training for researchers who want to submit or leverage proteomics data<\/a>. The team also reanalyses public proteomics datasets and disseminates them to other EMBL-EBI resources, including <a href=\"https:\/\/www.uniprot.org\/\">UniProt<\/a> and <a href=\"https:\/\/www.ebi.ac.uk\/gxa\/home\">Expression Atlas<\/a>, to make the proteomics data easier to find and use by scientists from different fields.&nbsp;<\/p>\n\n\n\n<p>But nine people cannot manage the world\u2019s proteomics data, so a big priority for the team is collaborating with other institutes and experts, including ProteomeXchange, the <a href=\"https:\/\/hupo.org\/Proteomics-Standards-Initiative-(PSI)\" target=\"_blank\" rel=\"noreferrer noopener\">Proteomics Standards Initiative<\/a>, and the <a href=\"https:\/\/elixir-europe.org\/communities\/proteomics\">ELIXIR\u2019s Proteomics Community<\/a>.\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>What is next for proteomics data infrastructure?<\/strong><\/h2>\n\n\n\n<p>Alongside improved access to proteomics technology and the growing appetite for data sharing, proteomics also requires robust and sustained funding. Together, these factors will enable experimental and data infrastructures to support the discovery of new insights that can help us understand life, health, and disease better.&nbsp;<\/p>\n\n\n\n<p>\u201cIt\u2019s easy to take research infrastructures for granted and expect they will always be there, but the truth is that they require continuous funding, expertise, and community support,\u201d said Savitski.&nbsp;<\/p>\n\n\n\n<p>Proteomics continues to change at a rapid pace. The public availability of proteomics data makes it a prolific field for developing and training new AI methods, which are already helping to analyse more data to gain new insights that could be useful for precision medicine and beyond.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Another development on the horizon is the increasing amount of \u2018human sensitive proteomics data\u2019 (also as part of multiomics studies), meaning data that can\u2019t be made openly available due to legal and ethical reasons. This requires a different type of data infrastructure, which is currently in development at EMBL-EBI. \u201cWe\u2019re hoping to have something to present to the community towards the end of 2025,\u201d explained Vizcaino. \u201cThis is a crucial next step for leveraging proteomics data to guide precision medicine.\u201d<\/p>\n\n\n\n<p>\u201cNot all datasets are created equal,\u201d said Vizca\u00edno. \u201cBut it\u2019s gratifying to see proteomics coming into the spotlight, alongside genomics and bioimaging. If we want to understand how life works, what makes us ill, and what can help us get better, looking at the blueprint of the genome is not enough. We need different data types, and better ways of integrating them to extract knowledge and understand life in context.\u201d&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The dynamic world of proteomics is shaping the future of personalised medicine, but some obstacles stand in the way<\/p>\n","protected":false},"author":47,"featured_media":69201,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11054,17591],"tags":[28,474,227,36,49,212,1000,17693,4760,45],"embl_taxonomy":[2906,11096,18989,3750],"class_list":["post-69169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-perspectives","category-science-technology","tag-bioinformatics","tag-collaboration","tag-core-facility","tag-embl-ebi","tag-interdisciplinary","tag-medicine","tag-molecular-medicine","tag-molecular-systems-biology","tag-precision-medicine","tag-proteomics","embl_taxonomy-embl-ebi","embl_taxonomy-embl-ebi-proteomics-metabolomics","embl_taxonomy-juan-antonio-vizcaino","embl_taxonomy-proteomics-core-facility"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"both","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>The dynamic world of proteomics is shaping the future of personalised medicine, but some obstacles stand in the way<\/p>\n","related_links":[{"link_description":"EMBL Proteomics Core Facility","link_url":"https:\/\/www.embl.org\/groups\/proteomics\/"},{"link_description":"EMBL-EBI's PRIDE database for proteomics ","link_url":"https:\/\/www.ebi.ac.uk\/pride\/"},{"link_description":"ProteomeXchange Consortium","link_url":"https:\/\/www.proteomexchange.org\/"},{"link_description":"Free course: Proteomics - An introduction to EMBL-EBI resources","link_url":"https:\/\/www.ebi.ac.uk\/training\/online\/courses\/proteomics-an-introduction\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"a99d1a7c-ca83-4c00-ab61-d082d3e41ce3\";}","parents":[],"name":["EMBL-EBI"],"slug":"embl-ebi","description":"Where &gt; All EMBL sites &gt; EMBL-EBI"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"18699e63-ed43-40c6-8d1c-203db7ed72ee\";i:2;s:36:\"fa320779-c7ad-4452-8098-45274a32e62f\";}","parents":[],"name":["EMBL-EBI Proteomics & Metabolomics"],"slug":"embl-ebi-proteomics-metabolomics","description":"What &gt; EMBL-EBI Services &gt; EMBL-EBI Proteomics &amp; Metabolomics"},{"uuid":"a:2:{i:0;s:36:\"4428d1fd-441a-4d6d-a1c5-5dcf5665f213\";i:1;s:36:\"782fb2b1-5456-406c-a67d-70bc526bf523\";}","parents":[],"name":["Juan Antonio Vizcaino"],"slug":"juan-antonio-vizcaino","description":"Who &gt; Juan Antonio Vizcaino"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"ef0437fc-a5b7-4c73-bcfd-63bff16cb35e\";i:2;s:36:\"03134396-a6d4-4450-986c-cd806c85f0a7\";}","parents":[],"name":["Proteomics Core Facility"],"slug":"proteomics-core-facility","description":"What &gt; Services and facilities &gt; Proteomics Core Facility"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Proteomics: a different lens for precision medicine | EMBL<\/title>\n<meta name=\"description\" content=\"Proteomics is shaping the future of personalised medicine, and EMBL&#039;s experimental services and data resources are paving the way.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Proteomics: a different lens for precision medicine | EMBL\" \/>\n<meta property=\"og:description\" content=\"Proteomics is shaping the future of personalised medicine, and EMBL&#039;s experimental services and data resources are paving the way.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-10T07:48:06+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-23T12:37:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-v2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Oana Stroe\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Oana Stroe\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/\"},\"author\":{\"name\":\"Oana Stroe\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/95d28f359cc138357c5dcf79319ef414\"},\"headline\":\"Proteomics: a different lens for precision medicine\",\"datePublished\":\"2024-07-10T07:48:06+00:00\",\"dateModified\":\"2024-07-23T12:37:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/\"},\"wordCount\":1925,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/proteomics-a-different-lens-for-precision-medicine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/07\/2024-Proteomics-Data-Feature-v2.jpg\",\"keywords\":[\"bioinformatics\",\"collaboration\",\"core facility\",\"embl-ebi\",\"interdisciplinary\",\"medicine\",\"molecular medicine\",\"molecular systems biology\",\"precision medicine\",\"proteomics\"],\"articleSection\":[\"Perspectives\",\"Science &amp; 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