{"id":67001,"date":"2024-04-04T09:00:00","date_gmt":"2024-04-04T07:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=67001"},"modified":"2024-04-04T09:39:25","modified_gmt":"2024-04-04T07:39:25","slug":"building-the-cells-splicing-machine","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/","title":{"rendered":"Building the cell\u2019s splicing machine"},"content":{"rendered":"\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n      Summary    <\/h3>\n                <p class=\"vf-card__text\"><ul>\r\n<li>The spliceosome is a large, dynamic molecular machinery which helps cells remove non-coding information from pre-mRNA molecules before protein synthesis. \r\n<\/li><li>New research from the Galej Group has provided novel insights into the structure of one of the building blocks of the spliceosome, helping elucidate how some of the components come together and assemble.\r\n<\/li><li>Given that a large proportion of genetic disorders are linked to spliceosome dysfunction, a better understanding of its fundamental mechanisms may pave the way for novel therapies to improve human health.\r\n<\/li><\/ul><\/p>\n      <\/div>\n<\/article>\n\n\n\n\n<p>One of the most striking features of human genes is that genetic information required to produce proteins is stored in a discontinuous form, wherein the coding information (exons) is punctuated with non-coding segments known as introns. <a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01250-5\" target=\"_blank\" rel=\"noreferrer noopener\">A new study<\/a> from the Galej group at EMBL Grenoble contributes to a better understanding of the process by which this non-coding information is removed prior to protein synthesis.&nbsp;&nbsp;<\/p>\n\n\n\n<p>In order to produce functional proteins, the cell must remove introns from precursors of messenger RNA molecules called pre-mRNAs \u2013 a process known as pre-mRNA splicing. In a way, splicing is similar to movie editing, where individual video clips are cut and stitched together to form a coherent story.<\/p>\n\n\n\n<p>The splicing reaction is catalysed by a large and dynamic molecular machine known as the spliceosome. The spliceosome surveys messenger RNA molecules to identify the beginning and the end of each coding segment and puts them together in a faithful way. This is of critical importance as any inaccuracies in this process may have drastic consequences for gene expression outcomes.&nbsp;<\/p>\n\n\n\n<p>\u201cNumerous genetic disorders are linked directly or indirectly to either mutations in spliceosome components or the sequences that it recognises,\u201d said Wojtek Galej, Group Leader at EMBL Grenoble. \u201cTherefore, investigation of the pre-mRNA splicing has a huge medical relevance and understanding of its fundamental mechanism may pave the way for novel therapies to improve human health.\u201d<\/p>\n\n\n\n<p>The spliceosome is a very complex molecular machine, built from more than 100 proteins and five RNA molecules. These components are pre-assembled into five major building blocks known as small nuclear ribonucleoprotein particles (snRNPs, pronounced \u201csnurps\u201d). The Galej Group interrogated the structure of one of the building blocks of the spliceosome \u2013 the 20S U5 snRNP.&nbsp;<\/p>\n\n\n\n<p>The largest building block of the spliceosome is called the tri-snRNP complex and is formed from the interaction of three different snRNPs \u2013 U4, U5, and U6. Although scientists know the structure of the mature tri-snRNP, it remains unclear how exactly its numerous components assemble.&nbsp;<\/p>\n\n\n\n<p>Researchers from the Galej Group addressed this problem by analysing the structure of 20S U5 snRNP, one of the intermediates in this assembly pathway. Although this intermediate was first isolated more than three decades ago, its structure has remained elusive until now. The scientists purified their sample directly from human cells and visualised it using electron cryomicroscopy (cryoEM) and interpreted their data with the help of AlphaFold2, an <a href=\"https:\/\/www.embl.org\/about\/info\/annual-report\/ar2021\/alphafold-a-game-changer-for-structural-biology\">artificial intelligence-based system<\/a> for predicting protein structures.&nbsp;<\/p>\n\n\n\n<p>The researchers discovered that CD2BP2, one of the proteins in the tri-snRNP complex, acts as a molecular \u2018chaperone\u2019, helping the protein components of the complex come together and assemble correctly. This protein is only present in the precursor form of the complex and leaves it as soon as it reaches its mature state. To better understand the function of this factor, the team used CRISPR-Cas9 gene editing technology to create cell lines devoid of CD2BP2. With support from the Proteomics Core Facility at EMBL Heidelberg, the scientists found that in the absence of CD2BP2, snRNPs are produced less efficiently due to a potential roadblock in their assembly pathway.\u00a0<\/p>\n\n\n\n<p>\u201cWe started this project more than five years ago, and it has been a great collaborative effort of multiple people in the group looking at the problem from different angles. It is immensely satisfying to see final results coming together now,\u201d said Galej.<\/p>\n\n\n\n<p><em>This study was published alongside related work by scientists from the lab of Clemens Plaschka at the Research Institute of Molecular Pathology (IMP) on \u2018Late biogenesis and recycling of the human spliceosomal U5 snRNP\u2019. DOI:<\/em><a href=\"https:\/\/www.nature.com\/articles\/s41594-024-01243-4\"><em> <\/em><em>10.1038\/s41594-024-01243-4<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.<\/p>\n","protected":false},"author":120,"featured_media":67003,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17591],"tags":[718,485,183,37,3628,35],"embl_taxonomy":[9792,19261],"class_list":["post-67001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-technology","tag-cryo-em","tag-galej","tag-gene-expression","tag-grenoble","tag-splicing","tag-structural-biology","embl_taxonomy-embl-grenoble","embl_taxonomy-galej-group"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>A new study provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression<\/p>\n","related_links":[{"link_description":"Galej group","link_url":"https:\/\/www.embl.org\/groups\/galej\/"},{"link_description":"Capturing \u2018snapshots\u2019 of a crucial step in RNA splicing","link_url":"https:\/\/www.embl.org\/news\/science\/capturing-snapshots-of-a-crucial-step-in-rna-splicing\/"},{"link_description":"EMBL scientists receive prestigious ERC Starting Grants","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/erc-grants-2020\/"}],"source_article":[{"publication_title":"Structure of the human 20S U5 snRNP","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41594-024-01250-5","target":"_blank"},"publication_authors":"Schneider, S., Brandina, I., Peter, D. et al.","publication_source":"Nature Structural & Molecular Biology","publication_date":"11 March 2024","publication_doi":"10.1038\/s41594-024-01250-5"}],"in_this_article":false,"press_contact":"None","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"8f81131e-d37c-470c-848f-618fce652295\";}","parents":[],"name":["EMBL Grenoble"],"slug":"embl-grenoble","description":"Where &gt; All EMBL sites &gt; EMBL Grenoble"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"fc528877-4017-438f-85b4-de2b54c443f1\";i:2;s:36:\"b3d9805e-9765-4a93-a6bb-56dfdc7142ff\";}","parents":[],"name":["Galej Group"],"slug":"galej-group","description":"What &gt; Structural Biology (EMBL Grenoble) &gt; Galej Group"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Building the cell\u2019s splicing machine | EMBL<\/title>\n<meta name=\"description\" content=\"A new study provides deeper structural insight into the assembly of a critical molecular machine that removes non-coding information from genes during their expression.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Building the cell\u2019s splicing machine | EMBL\" \/>\n<meta property=\"og:description\" content=\"A new study provides deeper structural insight into the assembly of a critical molecular machine that removes non-coding information from genes during their expression.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:author\" content=\"https:\/\/www.facebook.com\/embl.org\" \/>\n<meta property=\"article:published_time\" content=\"2024-04-04T07:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-04T07:39:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"EMBL Communications\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"EMBL Communications\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\"},\"author\":{\"name\":\"EMBL Communications\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/24871c449497f3467a819096a01dd264\"},\"headline\":\"Building the cell\u2019s splicing machine\",\"datePublished\":\"2024-04-04T07:00:00+00:00\",\"dateModified\":\"2024-04-04T07:39:25+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\"},\"wordCount\":607,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg\",\"keywords\":[\"cryo-em\",\"galej\",\"gene expression\",\"grenoble\",\"splicing\",\"structural biology\"],\"articleSection\":[\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\",\"url\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\",\"name\":\"Building the cell\u2019s splicing machine | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg\",\"datePublished\":\"2024-04-04T07:00:00+00:00\",\"dateModified\":\"2024-04-04T07:39:25+00:00\",\"description\":\"A new study provides deeper structural insight into the assembly of a critical molecular machine that removes non-coding information from genes during their expression.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg\",\"width\":1000,\"height\":600,\"caption\":\"Representation of the tri-snRNP complex, formed by the interaction of three different snRNPs (small nuclear ribonucleoprotein particles) \u2013 U4, U5, and U6. Credit: Isabel Romero Calvo\/EMBL\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.embl.org\/news\/#website\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"name\":\"European Molecular Biology Laboratory News\",\"description\":\"News from the European Molecular Biology Laboratory\",\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"alternateName\":\"EMBL News\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.embl.org\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.embl.org\/news\/#organization\",\"name\":\"European Molecular Biology Laboratory\",\"alternateName\":\"EMBL\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"width\":300,\"height\":144,\"caption\":\"European Molecular Biology Laboratory\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/embl.org\/\",\"https:\/\/x.com\/embl\",\"https:\/\/www.instagram.com\/embl_org\/\",\"https:\/\/www.linkedin.com\/company\/15813\/\",\"https:\/\/www.youtube.com\/user\/emblmedia\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/24871c449497f3467a819096a01dd264\",\"name\":\"EMBL Communications\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/a10f86727aeac518ca0d662cea0f9860c8d6becb9f6357eb78c8cd4f474b2f36?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/a10f86727aeac518ca0d662cea0f9860c8d6becb9f6357eb78c8cd4f474b2f36?s=96&d=mm&r=g\",\"caption\":\"EMBL Communications\"},\"description\":\"Informing, inspiring, and engaging staff and society with EMBL\u2019s research, services and training. Through our communications and outreach activities we raise awareness of EMBL\u2019s innovative research and training programmes, cutting-edge science and technology, and activities for the benefit of Europe.\",\"sameAs\":[\"https:\/\/www.embl.org\/news\/\",\"https:\/\/www.facebook.com\/embl.org\",\"https:\/\/www.instagram.com\/embl_org\/\",\"https:\/\/www.linkedin.com\/company\/embl\/\",\"https:\/\/x.com\/embl\",\"https:\/\/www.youtube.com\/c\/EMBLorg\",\"https:\/\/en.wikipedia.org\/wiki\/European_Molecular_Biology_Laboratory\"],\"url\":\"https:\/\/www.embl.org\/news\/author\/embl-communications\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Building the cell\u2019s splicing machine | EMBL","description":"A new study provides deeper structural insight into the assembly of a critical molecular machine that removes non-coding information from genes during their expression.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/","og_locale":"en_US","og_type":"article","og_title":"Building the cell\u2019s splicing machine | EMBL","og_description":"A new study provides deeper structural insight into the assembly of a critical molecular machine that removes non-coding information from genes during their expression.","og_url":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/","og_site_name":"EMBL","article_publisher":"https:\/\/www.facebook.com\/embl.org\/","article_author":"https:\/\/www.facebook.com\/embl.org","article_published_time":"2024-04-04T07:00:00+00:00","article_modified_time":"2024-04-04T07:39:25+00:00","og_image":[{"width":1000,"height":600,"url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","type":"image\/jpeg"}],"author":"EMBL Communications","twitter_card":"summary_large_image","twitter_creator":"@embl","twitter_site":"@embl","twitter_misc":{"Written by":"EMBL Communications","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#article","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/"},"author":{"name":"EMBL Communications","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/24871c449497f3467a819096a01dd264"},"headline":"Building the cell\u2019s splicing machine","datePublished":"2024-04-04T07:00:00+00:00","dateModified":"2024-04-04T07:39:25+00:00","mainEntityOfPage":{"@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/"},"wordCount":607,"publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"image":{"@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","keywords":["cryo-em","galej","gene expression","grenoble","splicing","structural biology"],"articleSection":["Science &amp; Technology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/","url":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/","name":"Building the cell\u2019s splicing machine | EMBL","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage"},"image":{"@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","datePublished":"2024-04-04T07:00:00+00:00","dateModified":"2024-04-04T07:39:25+00:00","description":"A new study provides deeper structural insight into the assembly of a critical molecular machine that removes non-coding information from genes during their expression.","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/science-technology\/building-the-cells-splicing-machine\/#primaryimage","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","width":1000,"height":600,"caption":"Representation of the tri-snRNP complex, formed by the interaction of three different snRNPs (small nuclear ribonucleoprotein particles) \u2013 U4, U5, and U6. Credit: Isabel Romero Calvo\/EMBL"},{"@type":"WebSite","@id":"https:\/\/www.embl.org\/news\/#website","url":"https:\/\/www.embl.org\/news\/","name":"European Molecular Biology Laboratory News","description":"News from the European Molecular Biology Laboratory","publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"alternateName":"EMBL News","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.embl.org\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.embl.org\/news\/#organization","name":"European Molecular Biology Laboratory","alternateName":"EMBL","url":"https:\/\/www.embl.org\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","width":300,"height":144,"caption":"European Molecular Biology Laboratory"},"image":{"@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/embl.org\/","https:\/\/x.com\/embl","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/15813\/","https:\/\/www.youtube.com\/user\/emblmedia\/"]},{"@type":"Person","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/24871c449497f3467a819096a01dd264","name":"EMBL Communications","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a10f86727aeac518ca0d662cea0f9860c8d6becb9f6357eb78c8cd4f474b2f36?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a10f86727aeac518ca0d662cea0f9860c8d6becb9f6357eb78c8cd4f474b2f36?s=96&d=mm&r=g","caption":"EMBL Communications"},"description":"Informing, inspiring, and engaging staff and society with EMBL\u2019s research, services and training. Through our communications and outreach activities we raise awareness of EMBL\u2019s innovative research and training programmes, cutting-edge science and technology, and activities for the benefit of Europe.","sameAs":["https:\/\/www.embl.org\/news\/","https:\/\/www.facebook.com\/embl.org","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/embl\/","https:\/\/x.com\/embl","https:\/\/www.youtube.com\/c\/EMBLorg","https:\/\/en.wikipedia.org\/wiki\/European_Molecular_Biology_Laboratory"],"url":"https:\/\/www.embl.org\/news\/author\/embl-communications\/"}]}},"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"fimg_url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","featured_image_src":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/Galej-NSMB-paper_1000x600.jpg","_links":{"self":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/67001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/users\/120"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/comments?post=67001"}],"version-history":[{"count":8,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/67001\/revisions"}],"predecessor-version":[{"id":67569,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/67001\/revisions\/67569"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media\/67003"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media?parent=67001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/categories?post=67001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/tags?post=67001"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/embl_taxonomy?post=67001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}