{"id":66943,"date":"2024-03-11T11:09:33","date_gmt":"2024-03-11T10:09:33","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=66943"},"modified":"2024-03-12T15:45:50","modified_gmt":"2024-03-12T14:45:50","slug":"casting-new-light-on-gene-regulation-in-development","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/","title":{"rendered":"Casting new light on gene regulation in development"},"content":{"rendered":"\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n      Summary    <\/h3>\n                <p class=\"vf-card__text\"><ul>\r\n \t<li aria-level=\"1\"><span style=\"font-weight: 400;\">Enhancers are genetic elements that control when and where genes are expressed in many living systems and genetic differences within them have been linked to diseases; however, how genes use enhancers during different stages of\u00a0 development is poorly understood.<\/span><\/li>\r\n \t<li aria-level=\"1\"><span style=\"font-weight: 400;\">New research from scientists at EMBL Heidelberg has shown that the way genes are influenced by enhancers undergoes a change when cells forming a tissue transition from a precursor state to their final differentiated forms.\u00a0<\/span><\/li>\r\n \t<li aria-level=\"1\"><span style=\"font-weight: 400;\">The study demonstrates how different modes of gene regulation can facilitate flexibility on the one hand, and more deterministic (or instructive) regulation on the other, to facilitate the plasticity and complexity required to develop tissues and organs during embryonic development. <\/span><\/li>\r\n<\/ul><\/p>\n      <\/div>\n<\/article>\n\n\n\n\n<p>If you look at a nerve cell, a muscle cell, or a skin cell under the microscope, they appear strikingly different. However, every cell in our body has the same DNA and has descended from a common ancestor \u2013 the fertilised egg cell. The diversity we observe arises due to differentiation \u2013 a process during development where cells mature into their final functional forms.&nbsp;<\/p>\n\n\n\n<p>New research from the Furlong group at EMBL Heidelberg has identified a shift in how genes are regulated by DNA control regions called enhancers during the differentiation process, as cells go from the specified precursor stages (e.g. myoblasts) to more mature, functional forms (e.g. muscle). The study was recently published in <em>Nature Genetics.&nbsp;<\/em><\/p>\n\n\n\n<p>The Furlong group studies the fundamental principles that drive genome regulation during embryonic development. One of their main areas of focus is enhancers \u2013 DNA control regions that regulate gene expression, often despite being located a long way (in DNA terms) from the genes they control. In this, enhancers are like light switches that can turn genes \u2018on\u2019 or \u2018off\u2019 from a distance.&nbsp;<\/p>\n\n\n\n<p>\u201cOnce considered to be part of the \u2018junk\u2019 non-coding DNA that makes up about 97% of our genomes, enhancers are now understood to be critical for cellular function and development. However, more than 40 years after their discovery, there\u2019s still a lot we don\u2019t understand about how they function,\u201d said Eileen Furlong, Group Leader and Head of the Genome Biology Unit at EMBL Heidelberg.&nbsp;<\/p>\n\n\n\n<p>Scientists currently believe that enhancers convey information to the genes they regulate as part of large DNA loops or hubs. This allows the enhancers to physically interact with \u2018promoters\u2019 \u2013 regulatory DNA regions located at the beginning of genes. In one of the largest studies of its kind during embryonic development, Furlong and her team recently examined nearly 600 enhancers and promoters in developing nerve and muscle cells in the fruit fly embryo to determine how enhancer-promoter interactions are related to when they regulate gene expression.<\/p>\n\n\n\n<p>Previous studies in the field had shown two distinct modes of regulation. In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between the two directly affected gene expression. This is known as an \u2018instructive\u2019 mode of regulation. But in other contexts, scientists observed that enhancers begin interacting with a gene\u2019s promoter hours before the gene is expressed. This, known as a \u2018permissive\u2019 mode of regulation, allows a gene to be ready for activation long before it is expressed.\u00a0<\/p>\n\n\n\n<p>\u201cIt wasn\u2019t clear why one form of regulation was found in some contexts, while a different one was reported in another,\u201d said Tim Pollex, Research Staff Scientist at EMBL and the first author of this study. \u201cOur study directly addressed this conundrum, and we show that both types of regulation co-exist during embryogenesis. Developmental stage is the key to determining which is the more dominant mode of regulation.\u201d<\/p>\n\n\n\n<p>In their study, the researchers examined when hundreds of enhancers interact with their gene\u2019s promoter during both muscle and neuronal development in<em> <\/em>fruit fly embryos, specifically during the times when gene expression is switched on or off.&nbsp;<\/p>\n\n\n\n<p>The scientists first looked at the stages when cells are specified, i.e. when the embryo determines which cells will form which cell types. At this stage, when the cells are not yet in their mature, differentiated forms, the researchers found that the way in which many developmental enhancers or gene promoters interact is strikingly similar between a future nerve cell or a future muscle cell (analogous to a shared control system, as shown in the left side of the illustration above). At this point, enhancers and promoters function within these \u2018permissive\u2019 environments to regulate which genes are switched on or off. The scientists speculate that this might allow gene expression patterns to undergo rapid changes. It may also help the cells to be much more flexible, and even change their fate if necessary.&nbsp;<\/p>\n\n\n\n<p>However, once the embryo develops further and these cells differentiate to their final form \u2013a more mature nerve or muscle cell, enhancer-promoter interactions become more diverse, complex and long-range. They also only emerge when and where a gene is expressed, being \u2018instructive\u2019 rather than \u2018pre-formed\u2019 or permissive. Additionally, in differentiated neurons and muscles, enhancer-promoter interactions become distinct for neuronal or muscle-specific genes (more complex and tissue-specific control systems, as shown on the right side of the illustration above).&nbsp;<\/p>\n\n\n\n<p>\u201c<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2022.11.18.516017v2\">A complementary study<\/a> from Evgeny Kvon\u2019s lab at UC Irvine, examined the relationship between enhancer-promoter activity in differentiated mouse tissues and came to a similar conclusion,\u201d said Furlong. \u201cThey show that in differentiated tissues, enhancer-promoter interactions are different between different tissues and that they occur at the time of gene expression. Such instructive enhancer-promoter regulation therefore appears to be an ancient feature of tissue differentiation ensuring the development of tissues with distinct functions.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.<\/p>\n","protected":false},"author":124,"featured_media":66949,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[55,565,478,665,873,563,17635,833,484,183,40,496,43],"embl_taxonomy":[18897,9796,19259],"class_list":["post-66943","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-development","tag-developmental-biology","tag-drosophila","tag-embryo","tag-embryogenesis","tag-embryonic-development","tag-enhancers","tag-fruit-fly","tag-furlong","tag-gene-expression","tag-gene-regulation","tag-genome-biology","tag-heidelberg","embl_taxonomy-eileen-furlong","embl_taxonomy-embl-heidelberg","embl_taxonomy-furlong-group"],"acf":{"vf_locked":false,"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>New research from EMBL Heidelberg shows how cells in developing embryos change the way they use enhancers to regulate gene expression as they mature and differentiate<\/p>\n","related_links":[{"link_description":"Surprisingly stable long-distance relationships ","link_url":"https:\/\/www.embl.org\/news\/science\/1407_enhancers\/"},{"link_description":"Chromatin gene-gene loops support the cross-regulation of genes with related function","link_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/38157845\/"},{"link_description":"Royal Society honour for Eileen Furlong","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/royal-society-honour-for-eileen-furlong\/"},{"link_description":"Furlong Group","link_url":"https:\/\/www.embl.org\/groups\/furlong\/"},{"link_description":"EMBL Genome Biology Unit","link_url":"https:\/\/www.embl.org\/research\/units\/genome-biology\/"}],"source_article":[{"publication_title":"Enhancer-promoter interactions become more instructive in the transition from cell fate specification to tissue differentiation","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41588-024-01678-x","target":""},"publication_authors":"Pollex T., et al.","publication_source":"Nature Genetics","publication_date":"11 March 2024","publication_doi":"10.1038\/s41588-024-01678-x"}],"in_this_article":false,"press_contact":"EMBL Generic","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:2:{i:0;s:36:\"4428d1fd-441a-4d6d-a1c5-5dcf5665f213\";i:1;s:36:\"a6ce8c14-af11-4834-81c1-10e29a4f6795\";}","parents":[],"name":["Eileen Furlong"],"slug":"eileen-furlong","description":"Who &gt; Eileen Furlong"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"ab46b6d4-71d8-49f8-b2f4-b326d4c8ea4e\";}","parents":[],"name":["EMBL Heidelberg"],"slug":"embl-heidelberg","description":"Where &gt; All EMBL sites &gt; EMBL Heidelberg"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"fe59a59f-fd7d-49b3-b3e4-bdd33a6642c3\";i:2;s:36:\"bead5498-7a84-4517-ab56-cb9704ea9c73\";}","parents":[],"name":["Furlong Group"],"slug":"furlong-group","description":"What &gt; Genome Biology &gt; Furlong Group"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Casting new light on gene regulation in development | EMBL<\/title>\n<meta name=\"description\" content=\"New research from EMBL Heidelberg shows how differentiating cells change the way they use enhancers to regulate gene expression\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Casting new light on gene regulation in development | EMBL\" \/>\n<meta property=\"og:description\" content=\"New research from EMBL Heidelberg shows how differentiating cells change the way they use enhancers to regulate gene expression\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-11T10:09:33+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-12T14:45:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/20240115_NatureGeneticsFurlong-scaled-e1710146517617.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Shreya Ghosh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Shreya Ghosh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/\"},\"author\":{\"name\":\"Shreya Ghosh\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/de071e57de42c03b5f23d1e391048fb2\"},\"headline\":\"Casting new light on gene regulation in development\",\"datePublished\":\"2024-03-11T10:09:33+00:00\",\"dateModified\":\"2024-03-12T14:45:50+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/\"},\"wordCount\":821,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/casting-new-light-on-gene-regulation-in-development\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/03\/20240115_NatureGeneticsFurlong-scaled-e1710146517617.jpg\",\"keywords\":[\"development\",\"developmental biology\",\"drosophila\",\"embryo\",\"embryogenesis\",\"embryonic development\",\"enhancers\",\"fruit fly\",\"furlong\",\"gene expression\",\"gene regulation\",\"genome biology\",\"heidelberg\"],\"articleSection\":[\"Science\",\"Science &amp; 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