{"id":6647,"date":"2016-03-07T15:37:51","date_gmt":"2016-03-07T14:37:51","guid":{"rendered":"http:\/\/news.embl.de\/?p=6647"},"modified":"2024-03-25T10:28:44","modified_gmt":"2024-03-25T09:28:44","slug":"1603-cohesin","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/","title":{"rendered":"A cohesive structure"},"content":{"rendered":"\n<p>From yeast to human, from birth to death \u2013 our cells are continually going through a cycle of growth and division. Central to this cycle is DNA \u2013 each time it must be correctly duplicated and distributed into the daughter cells when the cells divide. Failure to do so can result in cell death, cancer or infertility. A molecular machine crucial for the accurate implementation of this process is cohesin \u2013 a ring of proteins that latches onto the cell\u2019s DNA ensuring that identical copies of the DNA stay together and divide correctly into the daughter cells. But just how cohesin keeps everything together is not completely understood. \u201cWhat we would really like to understand is how closure of this ring is regulated and how it stays stable for long periods of time\u201d explains EMBL Grenoble group leader <a href=\"http:\/\/www.embl.fr\/research\/unit\/panne\/\" target=\"_blank\" rel=\"noopener noreferrer\">Daniel Panne<\/a>. Kyle Muir, a PhD student in Panne\u2019s group, has now succeeded in shedding some light on the process.<\/p>\n\n\n\n<p>In a paper published recently in <em>Cell Reports<\/em>, the researchers present the 3D atomic structure of one of the cohesin ring proteins (Scc1) bound together with a protein called Pds5. It has long been acknowledged that Pds5 is important for stabilizing the cohesin ring and, paradoxically, promoting its break up, but just how is not known. \u201cOur structure shows that there is a really small, but essential, interface for Pds5 to bind to the cohesin ring\u201d explains Muir, \u201cand this appears to be conserved across the animal kingdom \u2013 so all organisms from yeast to man have this exact same interface between the two proteins\u201d. This highlights the importance of Pds5 for the functioning of cohesin. Indeed additional cell biology experiments carried out in the lab of <a href=\"http:\/\/www.embl.de\/research\/units\/cbb\/haering\" target=\"_blank\" rel=\"noopener noreferrer\">Christian Haering<\/a> at EMBL Heidelberg to disrupt this interface resulted in the cells dying because they were unable to maintain chromosome pairs. Although details of the whole process remain elusive, the researchers believe Pds5 may be central for the recruitment of additional proteins which carry out different tasks during the cohesin cycle of establishment, stability and break-up. \u201cThe structure also reveals aspects of Pds5 that might enable it to control closure of the cohesin ring, which will allow researchers to design specific experiments to dissect the various parts of this crucial process\u201d concludes Muir.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Structural insights into how cohesin keeps DNA together during the cell cycle<\/p>\n","protected":false},"author":18,"featured_media":6671,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[66,29,37,35],"embl_taxonomy":[],"class_list":["post-6647","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-division","tag-crystallography","tag-grenoble","tag-structural-biology"],"acf":{"article_intro":"<p>EMBL Grenoble scientists present important insights into how DNA is organised during the cell cycle.<\/p>\n","related_links":false,"article_sources":[{"source_description":"<p>Muir KW\u00a0<em>et al. Cell Reports<\/em>, 25 February 2016. DOI:\u00a010.1016\/j.celrep.2016.01.078<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.1016\/j.celrep.2016.01.078"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A cohesive structure | EMBL<\/title>\n<meta name=\"description\" content=\"Structural insights into how cohesin keeps DNA together during the cell cycle\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A cohesive structure | EMBL\" \/>\n<meta property=\"og:description\" content=\"Structural insights into how cohesin keeps DNA together during the cell cycle\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2016-03-07T14:37:51+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-25T09:28:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/03\/1603-cohesin-ib1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Rosemary Wilson\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@rawilson80\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rosemary Wilson\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\"},\"author\":{\"name\":\"Rosemary Wilson\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/bb5e57a6c6c5c3b33a6a40b2d4c96e40\"},\"headline\":\"A cohesive structure\",\"datePublished\":\"2016-03-07T14:37:51+00:00\",\"dateModified\":\"2024-03-25T09:28:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\"},\"wordCount\":380,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/03\/1603-cohesin-ib1.jpg\",\"keywords\":[\"cell division\",\"crystallography\",\"grenoble\",\"structural biology\"],\"articleSection\":[\"Science\",\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\",\"name\":\"A cohesive structure | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/03\/1603-cohesin-ib1.jpg\",\"datePublished\":\"2016-03-07T14:37:51+00:00\",\"dateModified\":\"2024-03-25T09:28:44+00:00\",\"description\":\"Structural insights into how cohesin keeps DNA together during the cell cycle\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1603-cohesin\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/03\/1603-cohesin-ib1.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2016\/03\/1603-cohesin-ib1.jpg\",\"width\":620,\"height\":425,\"caption\":\"During cell division, DNA (purple) must be correctly grouped and divided between daughter cells. 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