{"id":66275,"date":"2024-02-12T16:29:43","date_gmt":"2024-02-12T15:29:43","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=66275"},"modified":"2024-07-22T11:52:03","modified_gmt":"2024-07-22T09:52:03","slug":"what-ive-learned-anne-ephrussi","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/what-ive-learned-anne-ephrussi\/","title":{"rendered":"Anne Ephrussi: what I&#8217;ve learned"},"content":{"rendered":"\n<p>In December, Anne Ephrussi began packing up her Heidelberg lab as she officially retired from EMBL to embark on new adventures.&nbsp; For those who know her, it probably won\u2019t come as a surprise that retirement doesn\u2019t seem like much of a slow-down. With manuscripts to complete, grants to review, and seminars to give, as well as being among the very first to receive EMBL\u2019s new researcher \u2018emeritus\u2019 status upon her departure, Anne Ephrussi\u2019s connection to the life sciences continues.&nbsp;<\/p>\n\n\n\n<p>A chat with her before her departure provided an opportunity to hear stories from throughout her career and allowed her to reflect on what she has learned along the way. But let us start with a brief introduction.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"180\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi-Borris-and-Harriet-wp-300x180.jpg\" alt=\"\" class=\"wp-image-66317\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi-Borris-and-Harriet-wp-300x180.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi-Borris-and-Harriet-wp-768x461.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi-Borris-and-Harriet-wp.jpg 1000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"vf-figure__caption\">Ephrussi\u2019s parents, both renowned scientists, encouraged creativity. Credit: \u00a9The Esther M. Zimmer Lederberg Trust.<\/figcaption><\/figure>\n\n\n\n<p>Ephrussi\u2019s career may have seemed like a foregone conclusion with two eminent life scientist parents, <a href=\"https:\/\/embryo.asu.edu\/pages\/boris-ephrussi-1901-1979\">Boris Ephrussi<\/a> and <a href=\"https:\/\/collections.nlm.nih.gov\/catalog\/nlm:nlmuid-101584575X620-doc\">Harriett Ephrussi-Taylor<\/a>.&nbsp; However, Ephrussi was determined not to be pigeonholed.&nbsp;<\/p>\n\n\n\n<p>When she was a little over six years old, her family moved from Paris to Cleveland, Ohio, where her parents joined several other scientists in establishing a unique developmental biology centre at Western Reserve University. Ephrussi\u2019s mother would die seemingly at the height of her scientific career, when Anne was only 12 years old. Her father would die just 11 years later \u2013 a jarring start to a lifelong training in resilience.&nbsp;<\/p>\n\n\n\n<p>Ephrussi attended Harvard University for her undergraduate studies followed by Massachusetts Institute of Technology (MIT) where she earned her PhD. After two postdocs \u2013 at Harvard University and the Whitehead Institute, MIT \u2013 she began her career at EMBL.&nbsp;&nbsp;<\/p>\n\n\n\n<p>In 1992, Ephrussi launched her EMBL research group. Using the <em>oskar<\/em> gene as a paradigm, her team focused on understanding how RNA molecules are transported and their translation regulated in animal development, and how the germ plasm forms and induces germline formation.&nbsp;<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n  <div>\n    <div>\n      <span style=\"font-weight: 400;\">\u201cI joined Anne\u2019s lab as a postdoc and was immediately impressed by how she would ask the key questions, pushing your project and your science further. What I was not expecting from someone as busy as Anne is how much she cares about her people, identifying who they deeply are to help them develop their skills and personality, and navigate through their career path.\u201d <\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n      \n      <div class=\"vf-blockquote_author\">\n        Florence Besse      <\/div>\n\n      \n      <div class=\"vf-blockquote_author__details\">\u2013 postdoc and staff scientist 2003-2008, currently head of Institut de Biologie Valrose, Nice<\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"197\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Lab-Day-2001-35-300x197.jpg\" alt=\"\" class=\"wp-image-66323\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Lab-Day-2001-35-300x197.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Lab-Day-2001-35-768x504.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Lab-Day-2001-35.jpg 833w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"vf-figure__caption\">Ephrussi worked closely with Matthias Hentze (centre) leading the EMBL International PhD Programme and establishing EMBL\u2019s postdoctoral programme while Fotis Kafatos (right) served as EMBL\u2019s Director General. From the EMBL Archive.<\/figcaption><\/figure>\n\n\n\n<p>With her mother as her role model, being a scientist and having a family was never a question for Anne. \u201cI didn\u2019t really think about it;&nbsp; I just got on with it. It was not even a question!\u201d Ephrussi said. \u201cFor me, having both a family and a lab is absolutely the best. It\u2019s having it all! My partner, Halld\u00f3r Stef\u00e1nsson, a social anthropologist, who later built and ran EMBL\u2019s Science and Society programme for 22 years, was a professor in Japan. I can\u2019t at all recommend seven years of commuting halfway around the world. This was emotionally very tough for both of us, but I daresay that having the care of our son Alexander and the lab is what kept me going. A challenge? For me, honestly, it was pure joy. But without the EMBL day-care, it would have been a different story.\u201d<\/p>\n\n\n\n<p>In addition to mentoring numerous predocs and postdocs in her own lab, Anne was actively involved in shaping EMBL\u2019s training programmes, and in 2005, became Head of the newly created <a href=\"https:\/\/www.embl.org\/training\/eicat\/\">EMBL International Centre for Advanced Training (EICAT)<\/a>. In this role, she oversaw EMBL\u2019s predoctoral and postdoctoral programmes, as well as EMBL\u2019s courses and conferences. She served as Associate Dean and then Dean of the PhD Programme and, together with her close colleague Matthias Hentze, developed what is now the <a href=\"https:\/\/www.embl.org\/about\/info\/postdoctoral-programme\/\">EMBL Postdoctoral Programme.<\/a> At the same time, she led EMBL\u2019s <a href=\"https:\/\/www.embl.org\/research\/units\/developmental-biology\/\">Developmental Biology Unit<\/a> from 2007 to 2021, whose focus she oriented towards organismal morphogenesis.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Her accolades are numerous. Ephrussi was elected to the French Acad\u00e9mie des Sciences in 2008 and to the US Academy of Sciences in 2022. In 2023, she received the Society for Developmental Biology Lifetime Achievement Award, and this year, the <a href=\"https:\/\/www.febs.org\/news\/anne-ephrussi-wins-the-febs-embo-women-in-science-award-2024\/\">FEBS\/EMBO Women in Science Award<\/a>.&nbsp;<\/p>\n\n\n\n<p>What follows is a small window into the career of Anne Ephrussi, along with some wisdom she gained along the way, as told in her own words.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n  <div>\n    <div>\n      <span style=\"font-weight: 400;\">\u201cAnne embodies excellence in training and is the driver behind EICAT\u2019s success. Through her vision, EICAT has evolved to be a leading training provider for scientists at all career levels. Personally, I am grateful for her mentorship and guidance over the years which has developed into a long-lasting friendship.\u201d<\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n      \n      <div class=\"vf-blockquote_author\">\n        Monika Lachner      <\/div>\n\n      \n      <div class=\"vf-blockquote_author__details\">EMBL Head of Internal Scientific Training and Dean of Graduate Studies<\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>The early years<\/strong><\/h2>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-end  size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"205\" height=\"300\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Anne-Ephrussi-96-205x300.jpg\" alt=\"\" class=\"wp-image-66319\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Anne-Ephrussi-96-205x300.jpg 205w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Anne-Ephrussi-96.jpg 561w\" sizes=\"auto, (max-width: 205px) 100vw, 205px\" \/><figcaption class=\"vf-figure__caption\">Anne Ephrussi in 1996. From the EMBL Archive.<\/figcaption><\/figure>\n\n\n\n<p><strong>Having two parents who are both renowned scientists,<\/strong> I think there were expectations, but not from them. My parents never put pressure on me to become a biologist, but they always encouraged creativity. Biology was always in the air, and it fueled much of my curiosity and questions. I would hang out in their labs whenever I could, asking to be given small tasks which I took very seriously!<\/p>\n\n\n\n<p><strong>My parents and I talked about science.<\/strong> I wasn&#8217;t reading papers obviously, but I would listen \u2013 and ask a lot of questions about their work. Fairly early on, I asked my father for a book on differentiation.<\/p>\n\n\n\n<p><strong>I swore I would not do biology.<\/strong> I didn\u2019t want to follow the obvious track. But science was part of the medium we lived in at home, although there was also much discussion of books and world history.<\/p>\n\n\n\n<p><strong>It was important to me <\/strong>to make and learn from my own mistakes. I was desperate to find my way on my own, resolved as I was to never deliberately use my parents\u2019 influence.<\/p>\n\n\n\n<p><strong>During my undergrad, I was very homesick for Europe <\/strong>and decided to return to Europe for my PhD \u2013 and was all set to join Walter Gehring\u2019s lab. But with my father\u2019s death days before I graduated, I realised I needed some time to process things. I cancelled those plans and remained in Cambridge, working in labs and taking a few courses. This is when I became really fascinated with immunology, the question of how we \u2013 our bodies &#8211; distinguish self from non-self. I was awe-struck by the papers revealing how antibody diversity is generated \u2013 through gene rearrangements and somatic mutation. This led me to apply to MIT and to join Susumu Tonegawa\u2019s lab, where I eventually tackled the question of why immunoglobulin genes are only transcribed in B cells.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n  <div>\n    <div>\n      <span style=\"font-weight: 400;\">\u201cAnne personifies many of the values that have made EMBL what it is. I worked with Anne daily for more than a decade to develop EMBL\u2019s training portfolio. Anne became far more than a colleague and a friend. She showed how two individuals who are quite different from each other could engage in constructive dialogue when they share a vision. I do not know anyone as devoted as Anne to fulfilling her responsibilities with fairness, equity, kindness, and respect. Likewise, she never shies away from difficult conversations and decisions, and I am deeply grateful for my time with her.\u201d<\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n      \n      <div class=\"vf-blockquote_author\">\n        Matthias Hentze      <\/div>\n\n      \n      <div class=\"vf-blockquote_author__details\">Director,  EMBL; Co-Director, Molecular Medicine Partnership Unit <\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Commitment to training<\/strong><\/h2>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"224\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/1996_Anne_Ephrussi_group142-300x224.jpg\" alt=\"\" class=\"wp-image-66321\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/1996_Anne_Ephrussi_group142-300x224.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/1996_Anne_Ephrussi_group142-1024x766.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/1996_Anne_Ephrussi_group142-768x574.jpg 768w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"vf-figure__caption\">In 1992, Ephrussi started her research group focussing on understanding how germ plasm is assembled and how RNA molecules are transported and their translation regulated in animal development. This is a shot of the Ephrussi group from 1996. Front row, left to right: Pavel Tomancak, Jola Glotzer, Mikl\u00f3s Ed\u00e9lyi, Anne-Marie Michon; Middle row: Antoine Guichet, Wolfgang Breitwieser, Anne Ephrussi, P\u00e9ter Z\u00e1vorzsky; Back row: Nicholas Gunkel, Finn-Hugo Markussen. From the EMBL Archive.<\/figcaption><\/figure>\n\n\n\n<p><strong>What makes my heart beat is actually my lab. <\/strong>In terms of the number of working hours and additional responsibilities, investing so much time and effort in developing scientific training at EMBL has posed challenges. But at a very personal level, it has been immensely gratifying, and a privilege, to help our youngest scientists excel through excellent training and find their way towards a future enriching career \u2013 be it in active research or another profession.&nbsp;<\/p>\n\n\n\n<p><strong>No guts, no glory. <\/strong>One of my first students and I were discussing an experiment and he said \u201cIt won\u2019t work. I don\u2019t want to try it.\u201d My slightly frustrated reply was: \u201cNo guts, no glory.\u201d Weeks later, as I joined my lab folk for lunch, I overheard them talking about their projects. Then one said, \u201cNah, forget it, it won\u2019t work.\u201d, and another retorted, \u201cCome on! No guts, no glory!\u201d That\u2019s when I realised we were off to the races; the lab was on its way. The words had been repeated, they resonated, and they became a motto. So yeah, I think it\u2019s essential to go out on a limb, to tinker, to go out of one\u2019s comfort zone, and to dare to try new things.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"225\" height=\"300\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/PastedGraphic-1-225x300.png\" alt=\"\" class=\"wp-image-66327\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/PastedGraphic-1-225x300.png 225w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/PastedGraphic-1-769x1024.png 769w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/PastedGraphic-1-768x1023.png 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/PastedGraphic-1.png 961w\" sizes=\"auto, (max-width: 225px) 100vw, 225px\" \/><figcaption class=\"vf-figure__caption\">Ephrussi&#8217;s most recent EMBL group in summer 2023. Front row left to right: Julia Grabowski, Simone Heber, Masroor Kahloon; Back row: Jayan Nair, Eve Mehtab, Anne, Mainak Bose.<\/figcaption><\/figure>\n\n\n\n<p><strong>I think that creating a postdoc programme was one of the most important things we invested in <\/strong>during my time at EMBL. The idea was born at a heads of units meeting chaired by Iain Mattaj, when we were discussing how to make the best use of funding that had been allocated to transversal research.&nbsp;<\/p>\n\n\n\n<p><strong>Right then and there, we decided to set up a competitive, interdisciplinary postdoctoral program <\/strong>that would attract top-quality, highly ambitious, and imaginative fellows to EMBL. It did, and, as hoped, has led to remarkable new collaborations and discoveries.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Reflections on EMBL<\/strong><\/h2>\n\n\n\n<p><strong>From the first day, EMBL was an extraordinary organisation<\/strong> where you could come in as a young group leader and take your ideas and run with them \u2013 and start pipetting on the first day.&nbsp; There was no pressure to publish in the first couple of years \u2013 certainly no pressure to go for low-hanging fruit, quite the contrary. We were \u2013 and are \u2013 encouraged to be bold and ask big questions. And new ideas emerged with nearly every conversation over coffee in the cafeteria. The cafeteria was, and remains, the most important spot on the EMBL Heidelberg campus.&nbsp;<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n  <div>\n    <div>\n      <span style=\"font-weight: 400;\">\u201cI joined Anne\u2019s lab in 1996 as the first Asian postdoc in her lab. As a mentor, Anne supported us to keep our own motivation in the research. She was skilful in discussing even with non-native English speakers like me, which made her lab truly international. In writing and editing papers, I sometimes sat side by side in her office with her, which gave me an indispensable experience in scientific writing at a high international level. Anne was kind and helpful even after I left her lab. Because her birthday is on the same day as mine, she remembers the day, and sends me an email every year, taking care of my scientific life.\u201d <\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n      \n      <div class=\"vf-blockquote_author\">\n        Tamaki Yano      <\/div>\n\n      \n      <div class=\"vf-blockquote_author__details\">postdoc 1996-1998, currently associate professor, Tohoku University, Japan<\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n\n\n\n<p><strong>The ability to work hand in hand with technology development <\/strong>has always been very special here. It is hugely empowering and a real feature of EMBL.<\/p>\n\n\n\n<p><strong>It is a real privilege to be able to do fundamental research. <\/strong>At EMBL, there isn\u2019t pressure to do applied research. At the same time, you are welcome and encouraged to go in that direction if you wish and your science takes you there.<\/p>\n\n\n\n<p><strong>There were lots of big questions. <\/strong>I came here with questions about germline development, having discovered that a particular protein &#8211; Oskar &#8211; could induce the formation of functional germ cells at different sites in the <em>Drosophila<\/em> embryo, based on the location where it was produced within the egg cell. This was amazing! And that experiment paved the way for much of our research on the properties of the Oskar protein and the mechanisms that ensure that it is only produced at the right place and at the right time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Philosophy towards life and science<\/strong><\/h2>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-end  size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"215\" height=\"300\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/DSC_2781-215x300.jpg\" alt=\"\" class=\"wp-image-66329\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/DSC_2781-215x300.jpg 215w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/DSC_2781-733x1024.jpg 733w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/DSC_2781-768x1072.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/DSC_2781.jpg 800w\" sizes=\"auto, (max-width: 215px) 100vw, 215px\" \/><figcaption class=\"vf-figure__caption\">Veit Riechmann, one of many postdocs who worked with Ephrussi. Riechmann, was a member of the Ephrussi group from 1999 to 2003, and has been a group leader at Universit\u00e4tsmedizin Mannheim in Germany since 2008. From the EMBL Archive.<\/figcaption><\/figure>\n\n\n\n<p><strong>To be paid by society to satisfy one\u2019s own curiosity is truly a privilege and a responsibility. <\/strong>This is one of the things I tell my lab every few months.&nbsp; It\u2019s not exactly a mantra, but do you realise that we scientists are being paid by society to answer questions that have piqued our curiosity? It\u2019s an incredible responsibility.<\/p>\n\n\n\n<p><strong>These are precious resources.<\/strong> We must be extremely rigorous in our analyses and ensure we have done everything possible not to <em>prove<\/em> our hypotheses, but rather to <em>disprove<\/em> them. It\u2019s about <em>not<\/em> falling in love with one\u2019s ideas and being misled by results.<\/p>\n\n\n\n<p><strong>I am fundamentally an optimist. <\/strong>And I believe this has been central in all respects of my life, including science.<\/p>\n\n\n\n<p><strong>Passion is key. And then there is luck. <\/strong>And logical thinking. And some guts and tinkering.&nbsp;<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-medium is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"213\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi_Besse_rgb-300x213.jpg\" alt=\"\" class=\"wp-image-66325\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi_Besse_rgb-300x213.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi_Besse_rgb-1024x728.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2024\/02\/Ephrussi_Besse_rgb-768x546.jpg 768w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption class=\"vf-figure__caption\">Florence Besse (left) worked as a postdoc and staff scientist in Ephrussi\u2019s lab at EMBL from 2003 to 2008. Today, Besse leads the Institut de Biologie Valrose in Nice, France. From the EMBL Archive.<\/figcaption><\/figure>\n\n\n\n<p><strong>Often scientists are asked about their any \u2018Aha! moments\u2019 <\/strong>\u2013 when something important is suddenly revealed.&nbsp; I have had the fortune of two major \u2018Aha\u2019 moments of my own. The first was when my grad student friend George Church and I discovered that proteins are bound to several sites of near-identical sequence within the immunoglobulin enhancers, but only in cells where these genes are transcribed. You have to understand that at that time, no one understood what enhancers were or how they worked. This finding was absolutely key and incredibly exciting. The second was when as a postdoc in Ruth Lehmann\u2019s lab I mislocalised <em>oskar<\/em> mRNA to the anterior of the developing egg, and this led to the formation of germ cells at that ectopic site in the embryo.<\/p>\n\n\n\n<p><strong>Several other such special moments I\u2019ve experienced second-hand <\/strong>\u2013 though no less intensely \u2013 with students and postdocs in my lab. The look of awe on their faces, silence, and then the eruption of joy. It\u2019s super intense. But it also, immediately, causes worry: is the result correct? Have we really excluded all other explanations? My mother used to say \u201cScience is a cruel mistress.\u201d I agree! But that\u2019s what comes with passion!<\/p>\n\n\n\n<p><strong>Our research is an extension of ourselves<\/strong>. If you are sloppy or faking data, you are cheating on your life. It makes one wonder how people value their own life if they are prepared to completely misrepresent it.&nbsp;&nbsp;<\/p>\n\n\n\n<p><strong>It\u2019s a question of ethics towards society. <\/strong>We owe society to do our very best research \u2013 rigorously and truthfully. And we owe it to ourselves.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote | vf-u-margin__bottom--600 vf-u-margin__top--600\">\n  <div>\n    <div>\n      <span style=\"font-weight: 400;\">\u201cThere is nothing like doing science. The joy of making sense of natural phenomena and having a hand in understanding how the world works never fades. But without guidance and encouragement from a mentor, this possibility would remain unknown to most of us, and we\u2019d be deprived of the rich and rewarding experiences that come from doing science. Anne provided me with such guidance and encouragement during my PhD and supported my growth as a scientist to become what I am now. I have been inspired by her scientific curiosity and personal integrity. Even many years after I left her lab, Anne has been there for me.\u201d<\/span>    <\/div>\n    \n          <footer class=\"vf-u-margin__top--600\">\n      \n      <div class=\"vf-blockquote_author\">\n         Marina Chekulaeva      <\/div>\n\n      \n      <div class=\"vf-blockquote_author__details\">PhD student 2001-2006, currently Group Leader at Max Delbr\u00fcck Center, Berlin<\/div>\n    <\/footer>\n      <\/div>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>After 32 years at EMBL \u2013 leading a developmental biology research group and later simultaneously serving as EMBL\u2019s Dean for its PhD programme, Anne Ephrussi has retired, ready to start her life\u2019s next chapter.<\/p>\n","protected":false},"author":100,"featured_media":66297,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,17593],"tags":[80,17303,565,322,17289,357,952,17683],"embl_taxonomy":[12016],"class_list":["post-66275","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lab-matters","category-people-perspectives","tag-alumni","tag-archive","tag-developmental-biology","tag-embl-archive","tag-embl50","tag-ephrussi","tag-history","tag-what-ive-learned","embl_taxonomy-eicat"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>From leading EMBL\u2019s developmental biology research unit to setting new directions for the organisation\u2019s training offerings, Anne Ephrussi has made an indelible mark on European life sciences<\/p>\n","related_links":[{"link_description":"Anne Ephrussi elected member of the US National Academy of Sciences","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/anne-ephrussi-elected-member-of-the-us-national-academy-of-sciences\/"},{"link_description":"Ephrussi reunion: face-to-face ","link_url":"https:\/\/www.embl.org\/news\/alumni\/1511-ephrussi-reunion\/"},{"link_description":"Feldberg Prize for Anne Ephrussi ","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/feldberg-prize-ephrussi\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"cac5b899-a450-4f36-a445-8508ae6b1134\";i:2;s:36:\"17483fa7-2c05-481a-a626-e2edafdab307\";}","parents":[],"name":["EICAT"],"slug":"eicat","description":"What &gt; 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