{"id":61431,"date":"2023-07-24T10:02:16","date_gmt":"2023-07-24T08:02:16","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=61431"},"modified":"2024-03-22T11:28:16","modified_gmt":"2024-03-22T10:28:16","slug":"new-therapies-to-improve-cardiovascular-health","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/","title":{"rendered":"New therapies to improve cardiovascular health"},"content":{"rendered":"\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n      <h3 class=\"vf-card__heading\">\n      Summary    <\/h3>\n                <p class=\"vf-card__text\"><ul>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Dilated cardiomyopathy (DCM) is a highly prevalent heart disease with limited treatment options, which is often caused by mutations in specific genes involved in heart function.<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Researchers from EMBL Heidelberg have now shown how mutations in one such gene\u00a0 \u2013 <\/span><i><span style=\"font-weight: 400;\">RBM20<\/span><\/i><span style=\"font-weight: 400;\"> \u2013 affect the localisation of the protein and identified the molecular interactions responsible for its transport into the nucleus.\u00a0<\/span><\/li>\r\n \t<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In a second study, the researchers demonstrated the effectiveness of a novel CRISPR-based gene editing approach in reversing <\/span><i><span style=\"font-weight: 400;\">RBM20<\/span><\/i><span style=\"font-weight: 400;\"> mutations and cardiac dysfunction in mouse models of DCM.\u00a0<\/span><\/li>\r\n<\/ul><\/p>\n      <\/div>\n<\/article>\n\n\n\n\n<p>Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure, affecting nearly 1 in 400 people worldwide. Around 40-50% of DCM cases are estimated to have an identifiable genetic cause, which explains why the disorder often runs in families. In a pair of new studies published in <em>Nature Communications<\/em>, researchers from EMBL Heidelberg&#8217;s <a href=\"https:\/\/www.embl.org\/groups\/steinmetz\/\">Steinmetz group<\/a> have explored the molecular underpinnings of a particular form of familial DCM and tested gene-editing approaches for treating such disorders.&nbsp;<\/p>\n\n\n\n<p>About 3% of familial DCM cases involve mutations in a crucial gene called <em>RBM20<\/em>. This gene, which helps regulate a type of RNA processing called \u2018alternative splicing\u2019, is predominantly expressed in cardiomyocytes, i.e. heart muscle cells. In the <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-39965-6\">first of the two studies<\/a>, the Steinmetz group explored the molecular pathways by which mutations in <em>RBM20<\/em> affect cardiomyocyte function.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>When proteins lose their way<\/strong><\/h2>\n\n\n\n<p>A defect in the genetic code may cause disease in different ways. In certain mutations, disease characteristics (or the \u2018phenotype\u2019) arise due to the gene&#8217;s normal function being disrupted by the mutation. If one thinks of the cell as a complex machine, the mutated gene can be considered a broken gear that slows down or halts normal function. For a long time, scientists believed this to be the main effect of <em>RBM20<\/em> mutations \u2013 it prevented the gene from performing its normal role in RNA splicing, in turn affecting cellular function.<\/p>\n\n\n\n<p>However, as the Steinmetz group explored in their study, the disease phenotype can also be caused by a protein behaving spuriously, causing damage by doing what it\u2019s not supposed to do <em>or<\/em> being where it\u2019s not supposed to be. In the analogy above, one could think of it as a faulty part leaking oil, which affects the other parts of the machine and messes up the entire system.<\/p>\n\n\n\n<p>In agreement with previous studies, the team showed that a mutation in the gene can cause the RBM20 protein to localise to the cytoplasm of the cell instead of the nucleus where it is normally found. While in the cytoplasm, RBM20 can form detrimental cytoplasmic granules that worsen disease phenotype, similar to other diseases involving protein mislocalisation, such as neurodegenerative diseases and cancer.<\/p>\n\n\n\n<p>\u201cThis distinction can affect how one approaches therapeutics,\u201d said Julia Kornienko, PhD student in the Steinmetz lab and the first author of the study. \u201cWhile, for a loss-of-function mutation, a viable strategy would be to supply more healthy RBM20 to the cell to rescue the RNA splicing defect, this would not work for mislocalised RBM20 since it would have no impact on the localisation.\u201d<\/p>\n\n\n\n<p>The team then used a genome-wide CRISPR-Cas9 screen and <a href=\"https:\/\/www.embl.org\/news\/science\/cell-sorting-enters-a-new-dimension\/\">image-enabled cell sorting (ICS)<\/a> \u2013 a next-generation cell sorting method advanced by the Steinmetz lab in collaboration with BD Biosciences and other researchers at EMBL \u2013 to tease out RBM20\u2019s molecular interactors. Through this process, they identified a protein \u2013 TNPO3 \u2013 as being responsible for transporting RBM20 from the cytoplasm to the nucleus. They also found that mutations in RBM20 can prevent this interaction, resulting in RBM20 accumulating in the cytoplasm.<\/p>\n\n\n\n<p>\u201cAchieving genome-wide scale without the ICS technology would have been very challenging, if at all possible,\u201d noted Kornienko. \u201cIn addition, an arrayed screen, even for a selected subset of the genome, would have taken a substantially longer time.\u201d<\/p>\n\n\n\n<p>When the researchers overexpressed TNPO3 in cells, it enhanced the nuclear import of RBM20 and reversed the RNA splicing defects caused by RBM20 mutations. This finding has implications for developing novel therapeutic approaches targeted at restoring nuclear localisation of RBM20, which the team is currently further investigating.&nbsp;<\/p>\n\n\n\n<p>\u201cThis is a novel interaction that had never been described before,\u201d said Kornienko. \u201cAt the moment, we are working on deciphering the structure of the RBM20\u2013TNPO3 complex in the lab. Knowing the exact structure of the complex will allow us to identify small molecule drugs that stabilise the interaction upon mutation and select a compound library to test for therapeutic effects <em>in vitro <\/em>or <em>in vivo<\/em>. We are also exploring other ways of restoring RBM20&#8217;s nuclear localisation <em>in vivo<\/em>. We are very excited about this conceptually novel approach to target RBM20 in DCM and hope it could improve therapy options for RBM20 patients in future.\u201d&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Targeted gene editing to the rescue<\/strong><\/h2>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-39352-1\">In the second study<\/a>, the researchers took a more direct approach towards reversing RBM20-caused cardiomyocyte dysfunction in mouse models of DCM.&nbsp;<\/p>\n\n\n\n<p>Current therapeutic strategies for DCM are severely limited in their effectiveness and accessibility, and often a heart transplant is the only option for advanced patients. Ever since the discovery of the CRISPR-Cas9 gene editing system, scientists have been exploring its potential in the treatment of human diseases caused by mutations in specific genes. Many such approaches depend on processes active in dividing cells, thus limiting their applicability for mature cells that do not divide, e.g. cardiomyocytes or nerve cells.&nbsp;<\/p>\n\n\n\n<p>The Steinmetz lab used a next-generation CRISPR-based system called base editing that can be used in such post-mitotic cells to selectively reverse mutations in RBM20 in cardiomyocytes. To do this, they injected mice carrying <em>Rbm20<\/em> mutations with a specially created viral vector that selectively targets cardiomyocytes and that carries a gene-delivery system that allows the genetic code of these cells to be edited at the site of the mutation.&nbsp;<\/p>\n\n\n\n<p>Within three months of this treatment, the researchers saw improvement in several disease phenotypes, such as heart pumping function, splicing deficiency, and expression of heart failure biomarkers. They estimate that they could reverse the mutation in almost 70% of the cardiomyocytes in the recipient mice, an impressive figure for therapies of this kind. Interestingly, the gene editing also reversed cytoplasmic mislocalisation of the RBM20 protein in these mice. Importantly, the researchers did not see any off-target editing in other parts of the body \u2013 the biggest reservation for transferring CRISPR-Cas9 editing approaches into clinics.&nbsp;<\/p>\n\n\n\n<p>\u201cGetting this method to work in mouse models was quite challenging,\u201d said Markus Grosch, postdoc in the Steinmetz lab and first author of this study. \u201cBy increasing the amount of the virus, decreasing the age (and consequently the weight) of the mice, and using cardiomyocyte-specific viral delivery, we could dramatically increase the editing efficacy.\u201d<\/p>\n\n\n\n<p>The researchers believe that in the future, in addition to serving as a possible treatment for DCM patients, such a strategy could also have potential as a preventative measure for those at very early stages of the disease or those who carry similar genetic mutations but have not yet developed DCM.&nbsp;<\/p>\n\n\n\n<p>\u201cOur team aims to explore genome-editing strategies to understand the genetic basis of complex phenotypes, and in doing so, transform the way we do biomedical research,\u201d said Lars Steinmetz, Dieter Schwarz Foundation Professor and Associate Group Leader at EMBL Heidelberg. \u201cDCM is one of the leading causes of heart failure and despite major advances in medicine, there are no targeted therapies available to patients. Studies like ours delve into the biology behind the disease to identify new therapeutic avenues and strategies to tackle biomedical challenges in the future.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease.<\/p>\n","protected":false},"author":124,"featured_media":61433,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[64,628,12740,1960,183,496,17253,43,539,329],"embl_taxonomy":[19383],"class_list":["post-61431","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-biology","tag-crispr","tag-flow-cytometry","tag-functional-genomics","tag-gene-expression","tag-genome-biology","tag-heart","tag-heidelberg","tag-research-highlight","tag-steinmetz","embl_taxonomy-steinmetz-group"],"acf":{"vf_locked":false,"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease<\/p>\n","related_links":[{"link_description":"Genome Biology Unit","link_url":"https:\/\/www.embl.org\/research\/units\/genome-biology\/"},{"link_description":"Steinmetz group","link_url":"https:\/\/www.embl.org\/groups\/steinmetz\/"},{"link_description":"The power of cell sorting: understanding heart disease, phase separation, plankton, and more","link_url":"https:\/\/www.embl.org\/news\/science\/the-power-of-cell-sorting-understanding-heart-disease-phase-separation-plankton-and-more\/"}],"source_article":[{"publication_title":"Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41467-023-39352-1","target":""},"publication_authors":"Grosch M., et al. ","publication_source":"Nature Communications","publication_date":"22 June 2023","publication_doi":"10.1038\/s41467-023-39352-1"},{"publication_title":"Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41467-023-39965-6","target":""},"publication_authors":"Kornienko J., et al. ","publication_source":"Nature Communications","publication_date":"18 July 2023","publication_doi":"10.1038\/s41467-023-39965-6"}],"in_this_article":false,"press_contact":"EMBL Generic","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"fe59a59f-fd7d-49b3-b3e4-bdd33a6642c3\";i:2;s:36:\"e3e93e44-11a7-4560-adc0-d9f49c362c3c\";}","parents":[],"name":["Steinmetz Group"],"slug":"steinmetz-group","description":"What &gt; Genome Biology &gt; Steinmetz Group"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New therapies to improve cardiovascular health | EMBL<\/title>\n<meta name=\"description\" content=\"EMBL researchers have made new strides into understanding and reversing genetic defects that may underlie familial heart disease.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New therapies to improve cardiovascular health | EMBL\" \/>\n<meta property=\"og:description\" content=\"EMBL researchers have made new strides into understanding and reversing genetic defects that may underlie familial heart disease.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2023-07-24T08:02:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T10:28:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Shreya Ghosh\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Shreya Ghosh\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\"},\"author\":{\"name\":\"Shreya Ghosh\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/de071e57de42c03b5f23d1e391048fb2\"},\"headline\":\"New therapies to improve cardiovascular health\",\"datePublished\":\"2023-07-24T08:02:16+00:00\",\"dateModified\":\"2024-03-22T10:28:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\"},\"wordCount\":1175,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg\",\"keywords\":[\"cell biology\",\"crispr\",\"flow cytometry\",\"functional genomics\",\"gene expression\",\"genome biology\",\"heart\",\"heidelberg\",\"research highlight\",\"steinmetz\"],\"articleSection\":[\"Science\",\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\",\"name\":\"New therapies to improve cardiovascular health | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg\",\"datePublished\":\"2023-07-24T08:02:16+00:00\",\"dateModified\":\"2024-03-22T10:28:16+00:00\",\"description\":\"EMBL researchers have made new strides into understanding and reversing genetic defects that may underlie familial heart disease.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg\",\"width\":1000,\"height\":600,\"caption\":\"Scientific illustration alluding to the role of gene and genome editing strategies in studying heart disease. The Steinmetz group found that gene editing can help correct mutations causing dilated cardiomyopathy and a genome-wide screen can be used to understand the molecular consequences of such mutations. Credit: Joana Gomes Campos de Carvalho\/EMBL\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.embl.org\/news\/#website\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"name\":\"European Molecular Biology Laboratory News\",\"description\":\"News from the European Molecular Biology Laboratory\",\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"alternateName\":\"EMBL News\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.embl.org\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.embl.org\/news\/#organization\",\"name\":\"European Molecular Biology Laboratory\",\"alternateName\":\"EMBL\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"width\":300,\"height\":144,\"caption\":\"European Molecular Biology Laboratory\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/embl.org\/\",\"https:\/\/x.com\/embl\",\"https:\/\/www.instagram.com\/embl_org\/\",\"https:\/\/www.linkedin.com\/company\/15813\/\",\"https:\/\/www.youtube.com\/user\/emblmedia\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/de071e57de42c03b5f23d1e391048fb2\",\"name\":\"Shreya Ghosh\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/7005cc910e37c4ca96a1b1e99e49ff50b20491aff5599e8b02b94f862665a4c4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/7005cc910e37c4ca96a1b1e99e49ff50b20491aff5599e8b02b94f862665a4c4?s=96&d=mm&r=g\",\"caption\":\"Shreya Ghosh\"},\"url\":\"https:\/\/www.embl.org\/news\/author\/shreya-ghoshembl-de\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New therapies to improve cardiovascular health | EMBL","description":"EMBL researchers have made new strides into understanding and reversing genetic defects that may underlie familial heart disease.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/","og_locale":"en_US","og_type":"article","og_title":"New therapies to improve cardiovascular health | EMBL","og_description":"EMBL researchers have made new strides into understanding and reversing genetic defects that may underlie familial heart disease.","og_url":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/","og_site_name":"EMBL","article_publisher":"https:\/\/www.facebook.com\/embl.org\/","article_published_time":"2023-07-24T08:02:16+00:00","article_modified_time":"2024-03-22T10:28:16+00:00","og_image":[{"width":1000,"height":600,"url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","type":"image\/jpeg"}],"author":"Shreya Ghosh","twitter_card":"summary_large_image","twitter_creator":"@embl","twitter_site":"@embl","twitter_misc":{"Written by":"Shreya Ghosh","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#article","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/"},"author":{"name":"Shreya Ghosh","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/de071e57de42c03b5f23d1e391048fb2"},"headline":"New therapies to improve cardiovascular health","datePublished":"2023-07-24T08:02:16+00:00","dateModified":"2024-03-22T10:28:16+00:00","mainEntityOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/"},"wordCount":1175,"publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","keywords":["cell biology","crispr","flow cytometry","functional genomics","gene expression","genome biology","heart","heidelberg","research highlight","steinmetz"],"articleSection":["Science","Science &amp; Technology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/","url":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/","name":"New therapies to improve cardiovascular health | EMBL","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","datePublished":"2023-07-24T08:02:16+00:00","dateModified":"2024-03-22T10:28:16+00:00","description":"EMBL researchers have made new strides into understanding and reversing genetic defects that may underlie familial heart disease.","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/science\/new-therapies-to-improve-cardiovascular-health\/#primaryimage","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","width":1000,"height":600,"caption":"Scientific illustration alluding to the role of gene and genome editing strategies in studying heart disease. The Steinmetz group found that gene editing can help correct mutations causing dilated cardiomyopathy and a genome-wide screen can be used to understand the molecular consequences of such mutations. Credit: Joana Gomes Campos de Carvalho\/EMBL"},{"@type":"WebSite","@id":"https:\/\/www.embl.org\/news\/#website","url":"https:\/\/www.embl.org\/news\/","name":"European Molecular Biology Laboratory News","description":"News from the European Molecular Biology Laboratory","publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"alternateName":"EMBL News","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.embl.org\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.embl.org\/news\/#organization","name":"European Molecular Biology Laboratory","alternateName":"EMBL","url":"https:\/\/www.embl.org\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","width":300,"height":144,"caption":"European Molecular Biology Laboratory"},"image":{"@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/embl.org\/","https:\/\/x.com\/embl","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/15813\/","https:\/\/www.youtube.com\/user\/emblmedia\/"]},{"@type":"Person","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/de071e57de42c03b5f23d1e391048fb2","name":"Shreya Ghosh","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7005cc910e37c4ca96a1b1e99e49ff50b20491aff5599e8b02b94f862665a4c4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7005cc910e37c4ca96a1b1e99e49ff50b20491aff5599e8b02b94f862665a4c4?s=96&d=mm&r=g","caption":"Shreya Ghosh"},"url":"https:\/\/www.embl.org\/news\/author\/shreya-ghoshembl-de\/"}]}},"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"fimg_url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","featured_image_src":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/07\/22062023_NewsVisual_SteinmetzGroup_1000x600px.jpg","_links":{"self":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/61431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/users\/124"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/comments?post=61431"}],"version-history":[{"count":6,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/61431\/revisions"}],"predecessor-version":[{"id":67293,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/61431\/revisions\/67293"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media\/61433"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media?parent=61431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/categories?post=61431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/tags?post=61431"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/embl_taxonomy?post=61431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}