{"id":55400,"date":"2023-01-23T10:27:36","date_gmt":"2023-01-23T09:27:36","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=55400"},"modified":"2024-03-22T16:33:00","modified_gmt":"2024-03-22T15:33:00","slug":"vikas-trivedi-from-embl-barcelona-receives-erc-synergy-grant","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/vikas-trivedi-from-embl-barcelona-receives-erc-synergy-grant\/","title":{"rendered":"Vikas Trivedi from EMBL Barcelona receives ERC Synergy Grant"},"content":{"rendered":"\n<p>EMBL Barcelona group leader <a href=\"https:\/\/www.embl.org\/groups\/trivedi\/\">Vikas Trivedi<\/a> and colleagues will receive more than EUR 10 million over the next six years for their project <em>BREAKDANCE,<\/em> that aims to identify the fundamental mechanisms that control the symmetry-breaking process in early embryos. Symmetry breaking is a recurring phenomenon in biology where similar cells start to take decisions, change their characteristics and develop into different tissues. So, how do cells take those decisions? How do cells at one end of the embryo know how to make a head, and cells at the other end to make a tail, if they all start the same in the early embryo? These are some of the questions that the \u2018<em>BREAKDANCErs\u2019<\/em> &#8211; a multidisciplinary team of biologists, engineers and physicists \u2013 will study during the next few years. <\/p>\n\n\n\n<p>Trivedi is coordinating this project, working together with <a href=\"https:\/\/www.crg.eu\/en\/verena_ruprecht\">Verena Ruprecht<\/a> from the Centre for Genomic Regulation (CRG) in Spain and <a href=\"https:\/\/www.ibdm.univ-amu.fr\/team\/physical-approaches-to-cell-dynamics-and-tissue-morphogenesis\/\">Pierre-Fran\u00e7ois Lenne<\/a> and <a href=\"http:\/\/www.matthiasmerkel.de\/\">Matthias Merkel<\/a>, from the Centre National de la Recherche Scientifique (CNRS) in France.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">An ambitious project<\/h2>\n\n\n\n<p><a href=\"https:\/\/erc.europa.eu\/apply-grant\/synergy-grant\">ERC Synergy Grant<\/a> projects address big research questions \u2013 so big that the awardees must team up with other research groups, often from different disciplines, which is central to the <em>BREAKDANCE<\/em> project.<\/p>\n\n\n\n<p>\u201cThe name, <em>BREAKDANCE,<\/em> refers to the dynamic interactions between cells in a tissue \u2013 their dance that breaks the symmetry.\u201d said Lenne, principal investigator at CNRS. &#8220;I am fascinated at how biological systems self-organise robustly. This project is a unique opportunity to understand how they achieve this.\u201d<\/p>\n\n\n\n<p>\u201cThe question that brought the four of us together is a simple one: how is that a developing embryo generates reproducible shapes and patterns of the different tissues that it\u2019s made up of?\u201d said Ruprecht, principal investigator at CRG. \u201cWe know that all tissues \u2013 early embryos, in particular \u2013 require a reference coordinate \u2013 a system of axes that can instruct the cells about top-bottom, front-back or left-right in a three-dimensional space. For example, to generate a functional body plan in an embryo, the cells of head, arms and legs have to be arranged correctly. If the axes are faulty, the arrangement and function of constituent cells will be wrong. Yet, we do not know how the gene networks and biophysical processes combine to build the animal body plan.\u201d<\/p>\n\n\n\n<p>\u201cThe challenge for us is to understand how do cells in a tissue work together to generate these axes in the first place that in turn \u2018guide\u2019 them. What is even more fascinating is that the shape and size of the tissue will in turn affect the behaviour of cells. Imagine a tissue that is spherical versus one that is cylindrical. Cells in a sphere can only sense bulk versus surface but in a cylinder, cells can also be oriented along a top-bottom axis. Thus, the geometry of tissue can influence cell-level mechano-chemical interactions, but we do not have a mechanistic understanding of how this multi-scale coordination happens in a developing embryo.\u201d Trivedi added, \u201cOur goal is to recreate this process at a level that allows us to identify the mechanisms underlying symmetry breaking.\u201d<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"778\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/ERC-SyG_Team-1024x778.jpg\" alt=\"\" class=\"wp-image-55402\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/ERC-SyG_Team-1024x778.jpg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/ERC-SyG_Team-300x228.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/ERC-SyG_Team-768x584.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">The \u2018<em>BREAKDANCErs<\/em>\u2019. From left to right: Verena Ruprecht, Vikas Trivedi, Pierre-Fran\u00e7ois Lenne and Matthias Merkel.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">An in-depth symmetry breaking study<\/h2>\n\n\n\n<p>Deciphering the rules of how the body plan of animals is developed is one of modern biology\u2019s important challenges. Despite the many groundbreaking advances in molecular biology and genetics, a separation of research fields studying genetic and biophysical mechanisms has slowed the progress in this context. It is only recently that researchers gained access to approaches that can mimic multicellular tissue organisation <em>in vitro<\/em>.<\/p>\n\n\n\n<p>The challenge, therefore, is to integrate experimental data from multiple scales with powerful computational modelling methods, and that requires a combined expertise in biology, physics, and engineering. This is where Trivedi and his colleagues teamed up to build this interdisciplinary consortium with complementary expertise in synthetic bottom-up approaches, functional <em>ex vivo <\/em>assays, embryonic stem cells based <em>in vitro <\/em>models from different species, advanced imaging, biophysical perturbations, data science, and theoretical modelling.<\/p>\n\n\n\n<p>As Merkel, PI at CRNS, puts it, \u201cthe ERC Synergy Grant will allow us to pioneer new approaches in understanding such multicellular coordination in living systems.\u201d Together they will address questions such as: how does global geometry control local cellular states and interactions? How does local cellular behaviour drive robust symmetry breaking at tissue-level? How far can geometry control cell fate specification in a species-independent manner?\u201d<\/p>\n\n\n\n<p>These are all fundamental scientific questions that feed into a better understanding of what drives the plan for an animal\u2019s body.<\/p>\n\n\n\n<p>\u201cThere are multiple ways in which symmetry can be broken, depending upon the chemical and mechanical properties of the cells,\u201d Trivedi said. \u201cWith this grant, we will perform a much more detailed analysis of the symmetry-breaking process across species and test these hypotheses in parallel. We will be training the next generation of young scientists who are comfortable with the cross talk between biology, physics, and engineering. Our dream is that if you give us a bunch of cells, we will be able to control the shape and pattern they generate. This level of control over cells in a dish is the Holy Grail in the field of tissue engineering and it\u2019s the driving motivation that brings the four of us together.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Success already<\/h2>\n\n\n\n<p>ERC Synergy Grants are highly competitive but open to researchers from all disciplines. In the 2022 call, the ERC funded only 10% of the applications. Because Trivedi and his collaborators comprise a relatively young research collective, they considered this funding an especially impressive achievement.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/TrivediGroup-1024x682.jpeg\" alt=\"\" class=\"wp-image-55404\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/TrivediGroup-1024x682.jpeg 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/TrivediGroup-300x200.jpeg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/TrivediGroup-768x512.jpeg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2023\/01\/TrivediGroup.jpeg 1600w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">The Trivedi Group (past and present members), an interdisciplinary group of researchers that study self-organisation in multicellular systems. Credit: Jia Le Lim<\/figcaption><\/figure>\n\n\n\n<p>\u201cWhen we went for the interviews in Brussels, I saw a quote in the corridor that read, \u2018The European Research Council Executive Agency is dedicated to selecting and funding the excellent ideas that have not happened yet, and the scientists that are dreaming them up.\u2019 This statement left a strong impression on me and this Synergy Grant has only reinforced my conviction we can achieve much more through collaboration and cooperation in science. This is great news for us but also for all researchers based in Europe,\u201d Trivedi said. \u201cWe hope we will be an example for young scientists to design ambitious projects and apply for the ERC Synergy Grant.\u201d<\/p>\n\n\n\n<p>This award is very much in line with EMBL\u2019s mission to <a href=\"https:\/\/www.embl.org\/international-relations\/\">coordinate and integrate life sciences<\/a> in Europe. For the next six years, BREAKDANCE will bring together four teams based in two different countries in an effort to discover the underlying fundamental laws of life.<\/p>\n\n\n\n<p>This is the first Synergy Grant awarded to EMBL Barcelona, but also to EMBL in general within the Horizon Europe 2021-2027 programme.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The group leader, together with three other principal investigators, has been awarded the ERC Synergy Grant, one of the most prestigious public grants in Europe.<\/p>\n","protected":false},"author":94,"featured_media":55406,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17597,3],"tags":[149,497,565,543,679],"embl_taxonomy":[9762,19389],"class_list":["post-55400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-embl-announcements","category-lab-matters","tag-award","tag-barcelona","tag-developmental-biology","tag-erc-grant","tag-trivedi","embl_taxonomy-embl-barcelona","embl_taxonomy-trivedi-group"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>Trivedi group \u2013 with CRG and CNRS collaborators \u2013 to embark on <em>BREAKDANCE<\/em> project that aims to bring together multidisciplinary researchers to study the mechanisms of how animal body plans develop<\/p>\n","related_links":[{"link_description":"Trivedi Group","link_url":"https:\/\/www.embl.org\/groups\/trivedi\/"},{"link_description":"EMBL Barcelona","link_url":"https:\/\/www.embl.org\/sites\/barcelona\/"},{"link_description":"ERC Synergy Grant","link_url":"https:\/\/erc.europa.eu\/apply-grant\/synergy-grant"},{"link_description":"CORDIS","link_url":"https:\/\/cordis.europa.eu\/projects\/en"}],"source_article":false,"in_this_article":false,"press_contact":"EMBL Generic","article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"762176bb-d12e-4c94-8964-6dbb76e15c42\";}","parents":[],"name":["EMBL Barcelona"],"slug":"embl-barcelona","description":"Where &gt; All EMBL sites &gt; EMBL 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