{"id":54062,"date":"2022-11-09T17:01:00","date_gmt":"2022-11-09T16:01:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=54062"},"modified":"2022-11-09T17:01:06","modified_gmt":"2022-11-09T16:01:06","slug":"new-molecular-microscopy-uncovers-how-breast-cancer-spreads","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/new-molecular-microscopy-uncovers-how-breast-cancer-spreads\/","title":{"rendered":"New molecular microscopy uncovers how breast cancer spreads"},"content":{"rendered":"\n<p>New technology can trace which populations of breast cancer cells are responsible for the spread of the disease. This highlights for the first time that\u00a0the location of cancer cells could be as important in tumour growth as mutations.\u00a0\u00a0<\/p>\n\n\n\n<p>The tool was created by a team from the Wellcome Sanger Institute, EMBL\u2019s European Bioinformatics Institute (EMBL-EBI), the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), the Science for Life Laboratory in Sweden, and collaborators. It could be used to help answer some of the big questions about cancer, such as why some cancer cells spread, how treatment resistance is formed, and why some therapies fail.&nbsp;&nbsp;<\/p>\n\n\n\n<p>The new study, <a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05425-2\" target=\"_blank\" rel=\"noreferrer noopener\">published in the journal <em>Nature<\/em><\/a>, shows how it is now possible to map tumour development, combining the cancer cells&#8217; genetic information with that of surrounding cell types, and how they interact with their environment over time. In the future, this approach could be used to see how treatments influence cancer at the genetic level, and also track how tumours interact with the immune system and their environment.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Breast cancer progression<\/strong><\/h2>\n\n\n\n<p>There were an <a href=\"https:\/\/canceratlas.cancer.org\/the-burden\/europe\/\" target=\"_blank\" rel=\"noreferrer noopener\">estimated 3.9 million new cancer cases and 1.9 million cancer deaths in Europe in 2018<\/a>. Female breast cancer cases made up 13% of cases with around 523,000 new cases reported across the continent.<\/p>\n\n\n\n<p>Breast cancer commonly starts when cells start to grow uncontrollably, often due to mutations in the cells. Over time, the tumour becomes a patchwork of cells, called cancer clones, each with different mutations. As they are genetically different, they can have different reactions to treatments. For example, some of these cancer cells could become resistant to treatment, or some could spread around the body.&nbsp;<\/p>\n\n\n\n<p>The mutations that occur will be influenced by what is happening around the cancer, the surrounding cells, and the individual\u2019s immune system. Therefore, being able to study the environment that a cancer cell is in, what mutations arise, and which cancer cells spread gives a complete view of tumour evolution.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>New technology to map cancer&nbsp;<\/strong><\/h2>\n\n\n\n<p>The new technology described in this study uses hundreds of thousands of tiny fluorescent molecular probes to interrogate cellular DNA and RNA, and scan large pieces of tissue using fluorescence microscopy. It can genetically and physically map out a tumour&#8217;s unique set of clones, measure how their gene expression patterns change, and show how they interact with their environment.&nbsp;<\/p>\n\n\n\n<p>\u201cWe have created a system that combines computational and experimental techniques that allows us to map evolutionary cancer lineages in their natural habitat of human tissue,\u201d said <a href=\"https:\/\/www.ebi.ac.uk\/people\/person\/artem-lomakin\/\">Artem Lomakin, first author from EMBL-EBI and the DKFZ<\/a>. \u201cWhile it has been previously possible to trace the lineage of cancer tumour cells in an experimental setup, this is the first time that multiple lineages were traced in human tissues, giving a complete overview of breast cancer development in the body. Insights generated by our system were impossible to get before, especially at this scale.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Cancer spread depends on tumour environment<\/strong><\/h2>\n\n\n\n<p>The team found that across multiple stages of breast cancer development there were specific, and often unexpected, patterns of clone growth. They also found that genetic clones behave differently depending on where in the breast they originated.&nbsp;<\/p>\n\n\n\n<p>The results also suggest that sometimes it is not only genetics that influences how cancers grow, but also the location of the tumours. In this case, genetics can be used as a tool to find out more about what happened in the situation that drove the cancer clones to spread around the body.&nbsp;<\/p>\n\n\n\n<p>\u201cCancer is caused by genetic mutations in a cell and this research was the first time that we were able to use DNA base specific probes to target dozens of these mutations in a set of cancer cell clones,\u201d said <a href=\"https:\/\/www.su.se\/english\/profiles\/matsn-1.191373\" target=\"_blank\" rel=\"noreferrer noopener\">Mats Nilsson, co-senior author from the Science for Life Laboratory at Stockholm University<\/a>. \u201cThis innovative technique allowed us to accurately reconstruct the spread of these clones. An important insight from our research is that it may not be the genetic changes alone that are the reason that the cancer cells survive and spread; it could also be where they are. This adds an additional layer of complexity as well as new potential ways to target the disease. It may also offer explanations about why some treatments only work in some individuals, even if they have similar mutations to others, as the tumours are found in different areas of the breast.\u201d&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Future therapies and disease prevention<\/strong><\/h2>\n\n\n\n<p>In the future, it could be possible to develop therapies that could prevent or lessen the cancer\u2019s ability to grow and spread, by influencing the environment around the tumour. In addition to this, researchers could use the newly developed tool to test how new treatments affect both cancer and its interaction with the immune system, giving a complete picture of how therapies work and any possible side effects.&nbsp;<\/p>\n\n\n\n<p>\u201cSequencing cancer tumours can give us a good understanding of the genetic diversity in a tumour,\u201d said <a href=\"https:\/\/www.dkfz.de\/en\/AI-in-oncology\/index.php\" target=\"_blank\" rel=\"noreferrer noopener\">Moritz Gerstung, co-senior author from the DKFZ<\/a>. \u201cBut the exciting thing about this technology is that for the first time, we can see how the environment shapes cancer evolution. By not only being able to see which cancer clones progress to become more aggressive, but also which didn\u2019t, it will enable us to get a much better understanding of what the key steps are in tumour growth, and how we can lessen or prevent disease.\u201d&nbsp;<\/p>\n\n\n\n<p>\u201cOur research has created a tool that can trace which breast cancer cells go on to cause tumours in other parts of the body, and can help answer some of the big questions in cancer, such as why some cancer cells spread and some don\u2019t,\u201d said <a href=\"https:\/\/www.sanger.ac.uk\/person\/yates-lucy\/\" target=\"_blank\" rel=\"noreferrer noopener\">Lucy Yates, co-senior author from the Wellcome Sanger Institute<\/a>. \u201cTo fully understand and therefore treat breast cancer, we need to be able to see the entire picture of how the cancer interacts in the body, with the cells around it, and with the immune system. This new technology combines multiple techniques and expertise to do this, bringing together different approaches to give a complete view of cancer that has not been previously possible.\u201d<\/p>\n\n\n\n<p>This <a href=\"https:\/\/www.sanger.ac.uk\/news_item\/breast-cancer-spread-uncovered-by-new-molecular-microscopy\/\">press release was originally published on the Wellcome Sanger Institute website<\/a>.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads.<\/p>\n","protected":false},"author":77,"featured_media":54068,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11060,2],"tags":[28,965,38,36,42,5778,79,1748],"embl_taxonomy":[2906],"class_list":["post-54062","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-highlights","category-science","tag-bioinformatics","tag-breast-cancer","tag-cancer","tag-embl-ebi","tag-genomics","tag-human-ecosystems","tag-microscopy","tag-press-release","embl_taxonomy-embl-ebi"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"both","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads<\/p>\n","related_links":[{"link_description":"\u2018Patchwork\u2019 tumours prevalent across multiple cancer types","link_url":"https:\/\/www.ebi.ac.uk\/about\/news\/research-highlights\/patchwork-tumours\/"},{"link_description":"Genome sequencing accelerates cancer detection","link_url":"https:\/\/www.embl.org\/news\/science\/genome-sequencing-accelerates-cancer-detection-2\/"},{"link_description":"Artificial intelligence finds patterns of mutations and survival in tumour images\r\n","link_url":"https:\/\/www.ebi.ac.uk\/about\/news\/research-highlights\/ai-detects-mutations-in-tumour-images\/"}],"source_article":[{"publication_title":"Spatial genomics maps the structure, nature and evolution of cancer clones","publication_link":{"title":"","url":"https:\/\/www.nature.com\/articles\/s41586-022-05425-2","target":""},"publication_authors":"Lomakin A., et al","publication_source":"Nature","publication_date":"9 November 2022","publication_doi":"10.1038\/s41586-022-05425-2 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