{"id":52128,"date":"2022-09-06T12:00:00","date_gmt":"2022-09-06T10:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=52128"},"modified":"2024-03-22T11:58:34","modified_gmt":"2024-03-22T10:58:34","slug":"erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/","title":{"rendered":"ERC Proof-of-Concept grant provides way to realise commercial potential of \u2018SpaceM\u2019 technology"},"content":{"rendered":"\n<p>A new <a href=\"https:\/\/erc.europa.eu\/funding\/proof-concept\">Proof of Concept<\/a> grant from the prestigious European Research Council will provide a way for fundamental metabolomics research to realise its commercial potential and promise in aiding drug development and precision medicine.<\/p>\n\n\n\n<p>EMBL team leader Theodore Alexandrov will take forward an innovative technology developed through his earlier ERC Consolidator grant. &nbsp;Known as METADRUG, the new project aims to commercialize SpaceM, a method that Alexandrov and his research team developed to identify pivotal changes in a cell\u2019s metabolites, which can help elucidate the mechanism of action of drugs, at the single-cell level.<\/p>\n\n\n\n<p>\u201cThe technology of single-cell metabolomics can help address the crisis of modern drug development by offering novel capacities to profile metabolic drug response,\u201d Alexandrov said. \u201cWhat\u2019s key, it can uniquely resolve differences between individual cells thus revealing information possibly critical, yet previously hidden, behind population averages.\u201d<\/p>\n\n\n\n<p>Studying cell-to-cell variation this way can also facilitate translational research by providing currently unavailable information on drug efficacy and safety. This can be used to develop better cancer diagnostics and therapeutics targeting rare tumour cells. It can also be applied to health conditions related to ageing, diabetes, and liver disease.<\/p>\n\n\n\n<p>METADRUG will distinctly complement the commercialization of the SpaceM method already started at Denmark\u2019s BioInnovation Institute (BII) under a <a href=\"https:\/\/www.embl.org\/news\/lab-matters\/teamed-up-to-innovate\/\">recent collaboration agreement between EMBL and BII<\/a>. SpaceM is <a href=\"https:\/\/bii.dk\/news\/high-quality-project-from-embl-is-the-first-to-enter-the-bio-studio-program\/\">the first project at BII under its new Bio Studio programme<\/a> \u2013 a joint endeavour facilitated through EMBLEM, EMBL\u2019s tech transfer arm.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new grant will provide a way for fundamental metabolomic research to realise its commercial potential and promise in aiding drug development and precision medicine.<\/p>\n","protected":false},"author":100,"featured_media":43302,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,17591],"tags":[416,149,1794,543,43,219,4760],"embl_taxonomy":[19163],"class_list":["post-52128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lab-matters","category-science-technology","tag-alexandrov","tag-award","tag-disease","tag-erc-grant","tag-heidelberg","tag-metabolomics","tag-precision-medicine","embl_taxonomy-alexandrov-team"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"article_intro":"<p>Team Leader Theodore Alexandrov looks ahead with technology developed at EMBL that could aid drug discovery and development<\/p>\n","related_links":[{"link_description":"When \u2018good\u2019 cells go \u2018bad\u2019","link_url":"https:\/\/www.embl.org\/news\/science\/when-good-cells-go-bad\/"},{"link_description":"Teamed up to innovate","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/teamed-up-to-innovate\/"},{"link_description":"Alexandrov Team","link_url":"https:\/\/www.embl.org\/groups\/alexandrov\/"},{"link_description":"EMBL Structural and Computational Biology unit","link_url":"https:\/\/www.embl.org\/research\/units\/structural-and-computational-biology\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":"","vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"bd910dd7-0cda-4618-8bfa-d37fbda8438e\";i:2;s:36:\"7bb77bef-f32e-4df4-9cd1-d4cf60d86b2f\";}","parents":[],"name":["Alexandrov Team"],"slug":"alexandrov-team","description":"What &gt; Molecular Systems Biology &gt; Alexandrov Team","deprecated":true}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>ERC Proof-of-Concept grant provides way to realise commercial potential of \u2018SpaceM\u2019 technology | EMBL<\/title>\n<meta name=\"description\" content=\"EMBL Team Leader Theodore Alexandrov is awarded an ERC Proof-of-Concept grant to commercialise technology that can aid precision medicine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ERC Proof-of-Concept grant provides way to realise commercial potential of \u2018SpaceM\u2019 technology | EMBL\" \/>\n<meta property=\"og:description\" content=\"EMBL Team Leader Theodore Alexandrov is awarded an ERC Proof-of-Concept grant to commercialise technology that can aid precision medicine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-06T10:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T10:58:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2021\/10\/Theodore_Alexandrov-wp.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ivy Kupec\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ivy Kupec\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/\"},\"author\":{\"name\":\"Ivy Kupec\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/427f2c9b624bc32ffa67d80414712274\"},\"headline\":\"ERC Proof-of-Concept grant provides way to realise commercial potential of \u2018SpaceM\u2019 technology\",\"datePublished\":\"2022-09-06T10:00:00+00:00\",\"dateModified\":\"2024-03-22T10:58:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/\"},\"wordCount\":255,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/erc-proof-of-concept-grant-provides-way-to-realise-commercial-potential-of-spacem-technology\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2021\/10\/Theodore_Alexandrov-wp.jpg\",\"keywords\":[\"alexandrov\",\"award\",\"disease\",\"erc grant\",\"heidelberg\",\"metabolomics\",\"precision medicine\"],\"articleSection\":[\"Lab Matters\",\"Science &amp; 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