{"id":4876,"date":"2015-08-20T18:00:40","date_gmt":"2015-08-20T16:00:40","guid":{"rendered":"http:\/\/news.embl.de\/?p=4876"},"modified":"2024-04-19T15:25:14","modified_gmt":"2024-04-19T13:25:14","slug":"1508-membrane","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/","title":{"rendered":"First, find your membrane"},"content":{"rendered":"\n<p>Last year, Rainer Pepperkok (Head of <a href=\"http:\/\/www.embl.de\/services\/core_facilities\/\" target=\"_blank\" rel=\"noopener noreferrer\">Core Facilities<\/a>) showed that if you destroy the Golgi complex \u2013 the cell\u2019s packaging centre \u2013 it gets rebuilt. \u201cThat\u2019s fascinating!\u201d says group leader <a href=\"http:\/\/www.embl.de\/research\/units\/scb\/gavin\/\" target=\"_blank\" rel=\"noopener noreferrer\">Anne-Claude Gavin<\/a>. \u201cHow does the cell first know that it is damaged, and that it has to build it again? And how does it know when to stop?\u201d It\u2019s just one of a multitude of examples Gavin can give you of instances where the cell needs a sensing mechanism associated to the membranes that partition off different compartments like the Golgi or the nucleus \u2013 not to mention the membrane that encompasses the cell itself.<\/p>\n\n\n\n<div class=\"vf-video\" style=\"padding-top: 0; padding-bottom: 56.25%;\">\n    <iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/youtube.com\/embed\/e5nLZSdRwLE\" frameborder=\"0\" allow=\"autoplay; encrypted-media\" allowfullscreen><\/iframe>\n<\/div>\n\n\n\n<p>Such sensing mechanisms involve, among others, proteins that sense and dock onto a specific membrane. But many of those proteins are known to bind to lipids which exist in many membranes. So how do they \u2018know\u2019 which particular membrane to bind to at a given time \u2013 for example, to start a bud that will develop into a new yeast cell?<\/p>\n\n\n\n<p>Gavin\u2019s lab developed a new approach to this question, together with the labs of Peer Bork and Jan Ellenberg. It stemmed from a brainstorming session with postdoc Antoine-Emmanuel Saliba, who under <a href=\"http:\/\/www.embl.de\/training\/postdocs\/08-eipod\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">EMBL\u2019s Interdisciplinary Postdoc Programme<\/a> was affiliated to both the Gavin and <a href=\"http:\/\/www.embl.de\/research\/units\/cbb\/ellenberg\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Ellenberg groups<\/a>. \u201cWe were dreaming up a way to measure these protein-lipid interactions using microfluidics, because Antoine-Emmanuel had experience in microfluidics. We were thinking about something that was visual,\u201d she says. \u201cSo microfluidics, but with microscopy, using biochemical methods, and of course bioinformatics to process and analyse the data. Ivana Vonkova, a PhD student in my lab, developed the biochemical methods. Antoine-Emmanuel and Jan were the microfluidics and microscopy experts. Samy Deghou, from the <a href=\"http:\/\/www.embl.de\/research\/units\/scb\/bork\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Bork&nbsp;group<\/a>, came up with innovative ideas so that we could integrate and visualise the huge amount of data you produce when you run 30 000 experiments.\u201d<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>So microfluidics, but with microscopy, using biochemical methods, and of course bioinformatics to process and analyse the data.<\/p><\/blockquote>\n\n\n\n<p>In their 30 000 experiments, the team investigated how so-called pleckstrin homology domains (PH domains) \u2013 the \u2018hand\u2019 that many proteins use to attach themselves to membranes \u2013 bind to different artificial membranes. PH domains are known to bind to a group of lipids called PIPs. But virtually every membrane in the cell contains PIPs, so how does a given protein bind only to one particular type of membrane, at a specific time? Gavin and colleagues created \u2018bubbles\u2019 of membrane made up of a PIP and another signalling lipid. By playing with the concentration of PIPs and combining them with different lipids, they created 10000 different scenarios in which they could measure how well PH domains bound. Each scenario was run three times, to ensure results weren\u2019t due to chance.<\/p>\n\n\n\n<p>They found that the degree and timing of binding are fine-tuned by additional lipids. PIP acts as a flag, saying \u2018this is the membrane,\u2019 and the presence of a second lipid pinpoints further: \u2018this is the section of membrane to bind to <em>now<\/em>.\u2019<\/p>\n\n\n\n<p>For instance, when a yeast cell is about to reproduce, its cell membrane starts growing in one spot, creating a bud that eventually breaks loose as a separate cell. Some proteins with a PH domain are involved in this process by recognising a specific PIP called PI(4,5)P2 \u2013 which is present on all of the cell\u2019s membrane. The EMBL scientists discovered that this PH domain binding is much stronger if another lipid, phosphatidylserine, is present. This explains how PH domains can drive yeast budding, since phosphatidylserine accumulates in the section of membrane that is set to bud out.<\/p>\n\n\n\n<p>The EMBL scientists believe that other instances of protein-lipid binding on membranes likely also involve fine-tuning by a second lipid.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>Could it be that you recognise one lipid in a thin membrane, another in a more flexible membrane?<\/p><\/blockquote>\n\n\n\n<p>Next, Gavin and colleagues would like to investigate how the physical properties of membranes influence this recognition process. \u201cWe know that the endoplasmic reticulum is thin and floppy, whereas the plasma membrane is thick and rigid, \u2026 Could it be that you recognise one lipid in a thin membrane, another in a more flexible membrane?\u201d she wonders, adding: \u201cWe\u2019d like to explore this, either using real membranes, which will be challenging, or by mimicking these properties in our artificial membranes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Collaboration between scientists reveals collaboration between lipids.<\/p>\n","protected":false},"author":8,"featured_media":4882,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[50,28,365,64,302,237,195,398,75,57,245],"embl_taxonomy":[],"class_list":["post-4876","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-biochemistry","tag-bioinformatics","tag-bork","tag-cell-biology","tag-ellenberg","tag-gavin","tag-microfluidics","tag-pepperkok","tag-phd","tag-postdoc","tag-video"],"acf":{"article_intro":"<p>Collaboration between scientists reveals collaboration between lipids, in a study published in<em> Cell Reports<\/em>.<\/p>\n","related_links":[{"link_description":"Related paper: Ronchi, P. et al. Journal of Cell Science, 4 September 2014. DOI:10.1242\/jcs.150474","link_url":"http:\/\/dx.doi.org\/10.1242\/jcs.150474"},{"link_description":"Gavin Group","link_url":"http:\/\/www.embl.de\/research\/units\/scb\/gavin\/index.html"},{"link_description":"Ellenberg Group","link_url":"http:\/\/www.embl.de\/research\/units\/cbb\/ellenberg\/index.html"},{"link_description":"Bork Group","link_url":"http:\/\/www.embl.de\/research\/units\/scb\/bork\/index.html"}],"article_sources":[{"source_description":"<p>Vonkova, I., Saliba, A-E., Deghou, S.L. <em>et al. Cell Reports<\/em>, 20 August 2015. DOI:\u00a010.1016\/j.celrep.2015.07.054<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.1016\/j.celrep.2015.07.054"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>First, find your membrane | EMBL<\/title>\n<meta name=\"description\" content=\"Collaboration between scientists reveals collaboration between lipids, in a study published in Cell Reports.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"First, find your membrane | EMBL\" \/>\n<meta property=\"og:description\" content=\"Collaboration between scientists reveals collaboration between lipids, in a study published in Cell Reports.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-08-20T16:00:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-19T13:25:14+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sonia Furtado Neves\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Aur_ora\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sonia Furtado Neves\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\"},\"author\":{\"name\":\"Sonia Furtado Neves\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68\"},\"headline\":\"First, find your membrane\",\"datePublished\":\"2015-08-20T16:00:40+00:00\",\"dateModified\":\"2024-04-19T13:25:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\"},\"wordCount\":717,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg\",\"keywords\":[\"biochemistry\",\"bioinformatics\",\"bork\",\"cell biology\",\"ellenberg\",\"gavin\",\"microfluidics\",\"pepperkok\",\"phd\",\"postdoc\",\"video\"],\"articleSection\":[\"Science\",\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\",\"name\":\"First, find your membrane | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg\",\"datePublished\":\"2015-08-20T16:00:40+00:00\",\"dateModified\":\"2024-04-19T13:25:14+00:00\",\"description\":\"Collaboration between scientists reveals collaboration between lipids, in a study published in Cell Reports.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg\",\"width\":620,\"height\":425,\"caption\":\"Green staining labels the endoplasmic reticulum in this dividing human melanoma cell. IMAGE: Paul J.Smith and Rachel Errington, Wellcome Images (CC BY-NC-ND 2.0)\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.embl.org\/news\/#website\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"name\":\"European Molecular Biology Laboratory News\",\"description\":\"News from the European Molecular Biology Laboratory\",\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"alternateName\":\"EMBL News\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.embl.org\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.embl.org\/news\/#organization\",\"name\":\"European Molecular Biology Laboratory\",\"alternateName\":\"EMBL\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"width\":300,\"height\":144,\"caption\":\"European Molecular Biology Laboratory\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/embl.org\/\",\"https:\/\/x.com\/embl\",\"https:\/\/www.instagram.com\/embl_org\/\",\"https:\/\/www.linkedin.com\/company\/15813\/\",\"https:\/\/www.youtube.com\/user\/emblmedia\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68\",\"name\":\"Sonia Furtado Neves\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g\",\"caption\":\"Sonia Furtado Neves\"},\"description\":\"Sonia Furtado Neves is EMBL's Core Content Manager and Press Officer. The world never ceases to stun her, and she loves sharing that awe, wonder and amazement.\",\"sameAs\":[\"https:\/\/x.com\/Aur_ora\"],\"url\":\"https:\/\/www.embl.org\/news\/author\/sonia\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"First, find your membrane | EMBL","description":"Collaboration between scientists reveals collaboration between lipids, in a study published in Cell Reports.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/","og_locale":"en_US","og_type":"article","og_title":"First, find your membrane | EMBL","og_description":"Collaboration between scientists reveals collaboration between lipids, in a study published in Cell Reports.","og_url":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/","og_site_name":"EMBL","article_publisher":"https:\/\/www.facebook.com\/embl.org\/","article_published_time":"2015-08-20T16:00:40+00:00","article_modified_time":"2024-04-19T13:25:14+00:00","og_image":[{"width":620,"height":425,"url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","type":"image\/jpeg"}],"author":"Sonia Furtado Neves","twitter_card":"summary_large_image","twitter_creator":"@Aur_ora","twitter_site":"@embl","twitter_misc":{"Written by":"Sonia Furtado Neves","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#article","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/"},"author":{"name":"Sonia Furtado Neves","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68"},"headline":"First, find your membrane","datePublished":"2015-08-20T16:00:40+00:00","dateModified":"2024-04-19T13:25:14+00:00","mainEntityOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/"},"wordCount":717,"publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","keywords":["biochemistry","bioinformatics","bork","cell biology","ellenberg","gavin","microfluidics","pepperkok","phd","postdoc","video"],"articleSection":["Science","Science &amp; Technology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/","url":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/","name":"First, find your membrane | EMBL","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","datePublished":"2015-08-20T16:00:40+00:00","dateModified":"2024-04-19T13:25:14+00:00","description":"Collaboration between scientists reveals collaboration between lipids, in a study published in Cell Reports.","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.embl.org\/news\/science\/1508-membrane\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/science\/1508-membrane\/#primaryimage","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","width":620,"height":425,"caption":"Green staining labels the endoplasmic reticulum in this dividing human melanoma cell. IMAGE: Paul J.Smith and Rachel Errington, Wellcome Images (CC BY-NC-ND 2.0)"},{"@type":"WebSite","@id":"https:\/\/www.embl.org\/news\/#website","url":"https:\/\/www.embl.org\/news\/","name":"European Molecular Biology Laboratory News","description":"News from the European Molecular Biology Laboratory","publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"alternateName":"EMBL News","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.embl.org\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.embl.org\/news\/#organization","name":"European Molecular Biology Laboratory","alternateName":"EMBL","url":"https:\/\/www.embl.org\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","width":300,"height":144,"caption":"European Molecular Biology Laboratory"},"image":{"@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/embl.org\/","https:\/\/x.com\/embl","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/15813\/","https:\/\/www.youtube.com\/user\/emblmedia\/"]},{"@type":"Person","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68","name":"Sonia Furtado Neves","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g","caption":"Sonia Furtado Neves"},"description":"Sonia Furtado Neves is EMBL's Core Content Manager and Press Officer. The world never ceases to stun her, and she loves sharing that awe, wonder and amazement.","sameAs":["https:\/\/x.com\/Aur_ora"],"url":"https:\/\/www.embl.org\/news\/author\/sonia\/"}]}},"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"fimg_url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","featured_image_src":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/1508-lipids-ib.jpg","_links":{"self":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/4876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/comments?post=4876"}],"version-history":[{"count":8,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/4876\/revisions"}],"predecessor-version":[{"id":20533,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/4876\/revisions\/20533"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media\/4882"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media?parent=4876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/categories?post=4876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/tags?post=4876"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/embl_taxonomy?post=4876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}