{"id":48172,"date":"2022-04-08T09:36:49","date_gmt":"2022-04-08T07:36:49","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=48172"},"modified":"2024-03-22T12:56:58","modified_gmt":"2024-03-22T11:56:58","slug":"a-metaphor-for-epigenetic-inheritance","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/","title":{"rendered":"A metaphor for epigenetic inheritance"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Inheriting non-genetic information<\/strong><\/h2>\n\n\n\n<p>Epigenetic modifications are reversible alterations of DNA structure. Examples include DNA methylation and modification of histones, the DNA binding proteins that control chromatin structure. These changes regulate gene expression in order to maintain cellular identity. Patterns of epigenetic modifications also respond to environmental factors, and can potentially cause changes in gene activity that are carried through cell divisions or even across generations \u2013 a process known as epigenetic inheritance. However, the prevalence of such epigenetic inheritance and the mechanisms regulating the process are still unclear.<\/p>\n\n\n\n<p>The Hackett group at EMBL Rome used a precision epigenetic editing strategy to reproduce environmentally-induced epigenetic modifications <em>in vivo<\/em> and tracked their inheritance to study the molecular factors responsible for this process.<\/p>\n\n\n\n<p>\u201cOur results show that the period of na\u00efve pluripotency during early mammalian development prevents transmission of abnormal epigenetic modifications to offspring. We found this safeguarding mechanism works, in part, through a chromatin factor called DPPA2,\u201d said Jamie Hackett. \u201cThe system helps to ensure a pristine epigenome that is primed for embryonic development is inherited.\u201d<\/p>\n\n\n\n<p>In contrast, the scientists observed that during later stages of development when cells are differentiated, acquired epigenetic modifications can propagate. As an example, they showed that induced epigenetic modifications that are able to promote tumor onset can be inherited by daughter cells during development. This previously undescribed mechanism could help understand susceptibility towards environmentally induced diseases, such as some cancers.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>From science to visual art<\/strong><\/h2>\n\n\n\n<p>The Hackett group study was recently published in <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/embj.2021108677\"><em>The EMBO Journal<\/em><\/a>, and served as inspiration for a cover illustration produced in-house. Marzia Munaf\u00f2, a postdoc in the Hackett group, merges her passion for drawing and science by creating scientific illustrations.<\/p>\n\n\n\n<p>She explained the process behind the illustration summarising the group\u2019s paper: \u201cThe first step in creating a scientific illustration is usually a briefing with the scientists. In this case it was easy, since I am also part of the research group, and I already knew the details of the study.\u201d During the initial brainstorming, Valentina Carlini, former PhD student in the Hackett group and first author of the paper, came up with the metaphor of a pruning process to explain the role of the DPPA2 protein on the epigenome of pluripotent cells.<\/p>\n\n\n\n<p>After collecting the scientific details, the illustrator starts an abstraction process, extrapolating key scientific concepts and associating them with visual objects. \u201cThat\u2019s a very interesting mental exercise,\u201d said Munaf\u00f2, \u201cAnd it\u2019s totally different from what we do in the lab, which is based on experimental observations and logical reasoning.\u201d<\/p>\n\n\n\n<p>Her final challenge was to transform the mental image into an illustration that is both scientifically sound and visually appealing. The result of this process is a beautiful image that summarizes the main findings of the study: the genome of the developing embryo is represented in the picture by a flowering tree, where histones are the fruits. Dppa2 acts as scissors, removing dried flowers, a metaphoric representation of aberrant histone modifications being erased during the na\u00efve pluripotency phase.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration<\/p>\n","protected":false},"author":92,"featured_media":48174,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[563,39,498,514],"embl_taxonomy":[9788,5144,19277,18953],"class_list":["post-48172","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-embryonic-development","tag-epigenetics","tag-hackett","tag-rome","embl_taxonomy-embl-rome","embl_taxonomy-epigenetics-and-neurobiology","embl_taxonomy-hackett-group","embl_taxonomy-james-hackett"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","article_intro":"<p>Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration<\/p>\n","related_links":[{"link_description":"Hackett Group","link_url":"https:\/\/www.embl.org\/groups\/hackett\/"}],"source_article":[{"publication_title":"Epigenetic inheritance is gated by na\u00efve pluripotency and Dppa2","publication_link":{"title":"","url":"https:\/\/www.embopress.org\/doi\/full\/10.15252\/embj.2021108677","target":""},"publication_authors":"Carlini V., et al.","publication_source":"EMBO Journal","publication_date":"4 April 2022","publication_doi":"10.15252\/embj.2021108677"}],"in_this_article":false,"press_contact":"None","vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"741d5d3d-f92f-4eb8-9195-55c96454a36b\";}","parents":[],"name":["EMBL Rome"],"slug":"embl-rome","description":"Where &gt; All EMBL sites &gt; EMBL Rome"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"7ca3ce91-dc32-47ea-8d4b-7a53c3a3a9fd\";i:2;s:36:\"a6e35bb0-c32d-4c9b-aadb-a19b6c7b060f\";}","parents":[],"name":["Epigenetics and neurobiology"],"slug":"epigenetics-and-neurobiology","description":"What &gt; Research Units &gt; Epigenetics and neurobiology"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"a6e35bb0-c32d-4c9b-aadb-a19b6c7b060f\";i:2;s:36:\"184ad143-e7b9-4fe0-ad8a-d0680aa47b3b\";}","parents":[],"name":["Hackett Group"],"slug":"hackett-group","description":"What &gt; Epigenetics and neurobiology &gt; Hackett Group"},{"uuid":"a:2:{i:0;s:36:\"4428d1fd-441a-4d6d-a1c5-5dcf5665f213\";i:1;s:36:\"e87754e5-4651-419c-be09-c6168b4bd6dc\";}","parents":[],"name":["James Hackett"],"slug":"james-hackett","description":"Who &gt; James Hackett"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A metaphor for epigenetic inheritance | EMBL<\/title>\n<meta name=\"description\" content=\"Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A metaphor for epigenetic inheritance | EMBL\" \/>\n<meta property=\"og:description\" content=\"Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-04-08T07:36:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T11:56:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/04\/Carlini_1000x600.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Rossana De Lorenzi\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rossana De Lorenzi\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/\"},\"author\":{\"name\":\"Rossana De Lorenzi\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/09fbcca4054ca2db027d0e970b2f1296\"},\"headline\":\"A metaphor for epigenetic inheritance\",\"datePublished\":\"2022-04-08T07:36:49+00:00\",\"dateModified\":\"2024-03-22T11:56:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/\"},\"wordCount\":507,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/a-metaphor-for-epigenetic-inheritance\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/04\/Carlini_1000x600.jpg\",\"keywords\":[\"embryonic development\",\"epigenetics\",\"hackett\",\"rome\"],\"articleSection\":[\"Science\",\"Science &amp; 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