{"id":4811,"date":"2015-09-03T09:44:14","date_gmt":"2015-09-03T07:44:14","guid":{"rendered":"http:\/\/news.embl.de\/?p=4811"},"modified":"2024-04-19T15:41:58","modified_gmt":"2024-04-19T13:41:58","slug":"1509-gerstung","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/","title":{"rendered":"Welcome: Moritz Gerstung"},"content":{"rendered":"\n<blockquote class=\"vf-blockquote\"><p>I hope that our research starts to fill in some of the blanks between molecular diagnostics and treatment decisions.<\/p><\/blockquote>\n\n\n\n<h3 class=\"wp-block-heading\">Where do you come from?<\/h3>\n\n\n\n<p>I come from Marburg, a small town in Germany infamous for the Marburg virus.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What do you think are the best things about science and technology in your adopted country?<\/h3>\n\n\n\n<p>When I got into genomics all of the main references were coming from the Genome Campus in the UK, which is the hub for biological data streams. It&#8217;s great to be at the heart of it.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What are your technical and\/or scientific interests?<\/h3>\n\n\n\n<p>I originally trained as a physicist but realised I was on a well-treaded path where all the great discoveries seemed already to have been made. One of my professors was applying his physics knowledge to biological problems, and this opened up a whole new world to me \u2013 where you can apply quantitative mathematics to get a more precise idea of what is going on. If you really want to see what\u2019s happening in a biological system you have to quantify it, use statistical methodology to separate the signal from the noise \u2013 and that\u2019s how I approach cancer research.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What will your group be focussing on?<\/h3>\n\n\n\n<p>My group will be trying to gain a quantitative understanding of cancer by leveraging large cohorts of patients to identify the unifying factors. The combination of mutations exhibited by each person, even people with the same cancer, are so very different that you need to look at many patients to find out what they have in common and how these different constellations affect their outcomes.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What is your work philosophy that you would like to share with your team?<\/h3>\n\n\n\n<p>If you mean a career philosophy, I would say: \u201cEnjoy what you&#8217;re doing and do what you enjoy\u201d. But in terms of why we\u2019re doing this work in the first place, I think it\u2019s really important to focus on translating what we do into useful information for clinicians who need to find the best possible treatment for their patients. We already have enough knowledge to inform clinical decisions much, much better, but guidelines tend to be simplistic and often lag behind current knowledge.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How do you see your group growing over the next year or so?<\/h3>\n\n\n\n<p>I certainly hope that it will grow a good deal! I\u2019m currently recruiting postdocs, one of which will report to both myself and Rebecca Fitzgerald at the NIHR Biomedical Research Centre and MRC.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Name one tool you can\u2019t do without.<\/h3>\n\n\n\n<p>Eclipse. It\u2019s the Swiss army knife of programming tools \u2013 it can do just about anything. But realistically, I think it will compete with Mail in future\u2026<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What is the best advice you have received in your career?<\/h3>\n\n\n\n<p>I once asked Mike Stratton for advice about an okay job offer I\u2019d received. He simply looked at me and said, &#8220;Is that the best deal you could ever imagine?&#8221; He encouraged me to hold out for the best, and that meant a lot. I refused the okay offer and went for an ideal offer at EMBL a year later \u2013 and here I am!<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What advice would you give someone starting out in your field of work?<\/h3>\n\n\n\n<p>Have bold ideas and don&#8217;t do what everyone else does. And don&#8217;t be disheartened by reviewers\u2019 comments. It\u2019s their task to check your work for weaknesses, even if their approach may seem superficial after all your years of hard work.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What impact would you like your work to have on research?<\/h3>\n\n\n\n<p>Cancer is such a common and complex disease, and if people are going to have the best treatment we need to provide a much stronger basis for rational decision-making. There is a huge gap between discoveries and applications, and for cancer in particular the standard of care tends to be one-size-fits-all. We can do better, but how, exactly? How can we expect people to embrace the complexity of cancer when there are so many concurrent features to look at?<\/p>\n\n\n\n<p>I hope that our research starts to fill in some of the blanks between molecular diagnostics and treatment decisions. I also think that we have to think about new ways of communicating our results to clinicians, for example using interactive web tools. This is challenging, but if we succeed we can make a real difference.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What inspires you?<\/h3>\n\n\n\n<p>There is so much to discover out there, you just need to approach it with open eyes and ask the right questions.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New group explores why patients with same cancer exhibit unique constellations of genetic mutations.<\/p>\n","protected":false},"author":13,"featured_media":4943,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,17593],"tags":[28,36,468,32,295],"embl_taxonomy":[],"class_list":["post-4811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lab-matters","category-people-perspectives","tag-bioinformatics","tag-embl-ebi","tag-gerstung","tag-health","tag-welcome"],"acf":{"article_intro":"<p>Why do patients with the same cancer exhibit different constellations of genetic mutations \u2013 and how does that affect their fates? New group leader Moritz Gerstung aims to find out.<\/p>\n","related_links":[{"link_description":"Gerstung research group","link_url":"http:\/\/www.ebi.ac.uk\/research\/gerstung"},{"link_description":"National Institute for Health Research (NIHR) Biomedical Research Centres","link_url":"http:\/\/www.nihr.ac.uk\/about\/biomedical-research-centres.htm"},{"link_description":"Medical Research Council (MRC)","link_url":"http:\/\/www.mrc.ac.uk\/"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Welcome: Moritz Gerstung, EMBL Research Group Leader<\/title>\n<meta name=\"description\" content=\"Moritz Gerstung is building a new EMBL-EBI research group to explore why patients with the same cancer exhibit unique constellations of genetic mutations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Welcome: Moritz Gerstung, EMBL Research Group Leader\" \/>\n<meta property=\"og:description\" content=\"Moritz Gerstung is building a new EMBL-EBI research group to explore why patients with the same cancer exhibit unique constellations of genetic mutations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:author\" content=\"www.facebook.com\/EMBLEBI\" \/>\n<meta property=\"article:published_time\" content=\"2015-09-03T07:44:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-19T13:41:58+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/GERSTUNG_Moritz_EMBL1-e1441263573394.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"424\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mary Todd Bergman\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@EMBLEBI\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mary Todd Bergman\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/\"},\"author\":{\"name\":\"Mary Todd Bergman\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/052a43af2beb3860bffa67c0f0474875\"},\"headline\":\"Welcome: Moritz Gerstung\",\"datePublished\":\"2015-09-03T07:44:14+00:00\",\"dateModified\":\"2024-04-19T13:41:58+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/\"},\"wordCount\":758,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1509-gerstung\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/08\/GERSTUNG_Moritz_EMBL1-e1441263573394.jpg\",\"keywords\":[\"bioinformatics\",\"embl-ebi\",\"gerstung\",\"health\",\"welcome\"],\"articleSection\":[\"Lab Matters\",\"People &amp; 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