{"id":46575,"date":"2022-02-23T10:00:00","date_gmt":"2022-02-23T09:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=46575"},"modified":"2024-07-23T22:31:13","modified_gmt":"2024-07-23T20:31:13","slug":"welcome-michael-dorrity","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/","title":{"rendered":"Welcome: Michael Dorrity"},"content":{"rendered":"\n<p>He may have started out in California\u2019s agricultural heartland, but Michael Dorrity, one of EMBL\u2019s newest group leaders, has moved from plant models to the zebrafish embryos to study developmental robustness in a changing world. Now, his work will be part of EMBL\u2019s growing planetary biology research portfolio. Dorrity tells us more about his research, why EMBL is exactly the right place to conduct it, and why listening to the \u2018sounds\u2019 around us can be a welcome break.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. Tell me about your research at EMBL.<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>Many species\u2019 environments will change over the coming decades, so I\u2019m looking at how the environment influences early life stages when environmental sensitivity is greatest. I\u2019m especially interested in differences between cell types. Do muscle cells respond to temperature stress the same way as skin cells? What makes certain cell types more sensitive to environmental stress?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. What environmental stressors most interest you?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>For me, it\u2019s temperature. The way cells mount a heat-shock response is an incredible feat of gene regulation, and we\u2019re still learning about the details decades after the initial discovery. On a larger scale, temperature fluctuations are associated with key events in Earth\u2019s history. Global temperature over the past 500 million years has experienced big swings that coincided with serious extinction events, but we still have extant diversity of life. Surviving lineages have experienced versions of Earth very different from the one we know today! How is that kind of history embedded into their genomes, and what tricks did they come up with to withstand temperature changes?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. How has your research changed since you began, and what prompted those changes?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>I grew up in central California where agriculture is everywhere, and I completed my undergraduate studies at the University of California, Davis. Consequently, I started my research with plants. My mentors in plant biology kept my focus broad and weren\u2019t afraid to use new tools or organisms to answer questions.<\/p>\n\n\n\n<p>My core interests haven\u2019t changed much, but one reason I gravitated toward zebrafish was related to sequencing technology. Using single-cell genomics, we can profile a whole zebrafish embryo and capture a meaningful proportion of cells from a single animal. With this, we can measure individual-to-individual variation in anatomy and gene expression, which is really powerful.<\/p>\n\n\n\n<p>Zebrafish embryos, because they develop entirely in the water, are subject to a variety of potential environmental stressors: water temperature, salinity, pH, and other nearby objects. Since nothing else can mitigate the variability during this crucial life stage, the fish must build buffering mechanisms themselves. We want to see what mechanisms they\u2019ve built and whether they will hold up to the changing climate.<\/p>\n\n\n\n<p>I wouldn\u2019t say that I\u2019ve moved on entirely from plants. If you want to learn about the environment, you must ask the plants: they sit there and experience it. They seem to have come up with good solutions to manage temperature variability \u2013 useful information for us animals.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. What are your favourite activities outside work?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>I like to bicycle, as well as kayak. I\u2019m really looking forward to learning the landscape around Heidelberg from both vantages. We had a good haul of chanterelle mushrooms (<em>Pfifferlinge<\/em>) in Washington state this past fall \u2013 hoping my new EMBL colleagues can share good spots to find some around Heidelberg.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. Best science movie of all time?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>Is there anyone who doesn\u2019t think that <em>Jurassic Park<\/em> is the best science movie of all time?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. On your Twitter bio, you note being a \u2018fan of sound\u2019. Can you elaborate? <\/strong><strong><\/strong><\/h3>\n\n\n\n<p>I get a lot of joy from music and listening to people and the incidental noises you hear while walking to work. A nice grounding technique for me is to catalogue sounds at a given moment \u2013 it\u2019s quite relaxing, and you\u2019d be surprised at how many sounds you notice then. If I had to pick a favourite sound, it might be when the wind picks up and shakes the leaves in a group of trees.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. Why is EMBL the right place for your research?<\/strong><strong><\/strong><\/h3>\n\n\n\n<p>This is the only place I\u2019ve found that seems fully invested in using cutting-edge molecular tools to study the effects of environmental change here and now; you can really see this in the new programme, \u2018Molecules to Ecosystems\u2019. No single field will be able to chart a reasonable course forward with this, and EMBL has many different foci of expertise. I feel lucky to be part of this team.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Michael Dorrity, one of EMBL\u2019s newest group leaders, is studying how the environment influences early life stages in zebrafish.<\/p>\n","protected":false},"author":100,"featured_media":47018,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,17593],"tags":[819,13070,1704,563,684,40,43,17693,5740,5736,2032,491,944,295,931],"embl_taxonomy":[19209,9796,19051],"class_list":["post-46575","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lab-matters","category-people-perspectives","tag-climate-change","tag-dorrity","tag-embl-programme","tag-embryonic-development","tag-environment","tag-gene-regulation","tag-heidelberg","tag-molecular-systems-biology","tag-phenotype","tag-planetary-biology","tag-sequencing","tag-single-cell-genomics","tag-structural-and-computational-biology","tag-welcome","tag-zebrafish","embl_taxonomy-dorrity-group","embl_taxonomy-embl-heidelberg","embl_taxonomy-michael-dorrity"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl","article_intro":"<p>Zebrafish embryos help this new EMBL group leader study the molecular basis of resilience to environmental stressors<\/p>\n","related_links":[{"link_description":"Dorrity group","link_url":"https:\/\/www.embl.org\/groups\/dorrity\/"},{"link_description":"Structural and Computational Biology unit","link_url":"https:\/\/www.embl.org\/research\/units\/structural-and-computational-biology\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","vf_locked":false,"field_article_language":{"value":"english","label":"English"},"article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"bd910dd7-0cda-4618-8bfa-d37fbda8438e\";i:2;s:36:\"9d07f491-7230-45f6-9d2f-f6059744a420\";}","parents":[],"name":["Dorrity Group"],"slug":"dorrity-group","description":"What &gt; Molecular Systems Biology &gt; Dorrity Group"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"ab46b6d4-71d8-49f8-b2f4-b326d4c8ea4e\";}","parents":[],"name":["EMBL Heidelberg"],"slug":"embl-heidelberg","description":"Where &gt; All EMBL sites &gt; EMBL Heidelberg"},{"uuid":"a:2:{i:0;s:36:\"4428d1fd-441a-4d6d-a1c5-5dcf5665f213\";i:1;s:36:\"3a90897f-efd4-43c7-ae10-1e9b693d9918\";}","parents":[],"name":["Michael Dorrity"],"slug":"michael-dorrity","description":"Who &gt; Michael Dorrity"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Welcome: Michael Dorrity | EMBL<\/title>\n<meta name=\"description\" content=\"Michael Dorrity, one of EMBL\u2019s newest group leaders, is studying how the environment influences early life stages in zebrafish.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Welcome: Michael Dorrity | EMBL\" \/>\n<meta property=\"og:description\" content=\"Michael Dorrity, one of EMBL\u2019s newest group leaders, is studying how the environment influences early life stages in zebrafish.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-23T09:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-23T20:31:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/02\/Dorrity_Michael_EMBLwp.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ivy Kupec\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ivy Kupec\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/\"},\"author\":{\"name\":\"Ivy Kupec\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/427f2c9b624bc32ffa67d80414712274\"},\"headline\":\"Welcome: Michael Dorrity\",\"datePublished\":\"2022-02-23T09:00:00+00:00\",\"dateModified\":\"2024-07-23T20:31:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/\"},\"wordCount\":749,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/welcome-michael-dorrity\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2022\/02\/Dorrity_Michael_EMBLwp.jpg\",\"keywords\":[\"climate change\",\"Dorrity\",\"embl programme\",\"embryonic development\",\"environment\",\"gene regulation\",\"heidelberg\",\"molecular systems biology\",\"phenotype\",\"planetary biology\",\"sequencing\",\"single-cell genomics\",\"structural and computational biology\",\"welcome\",\"zebrafish\"],\"articleSection\":[\"Lab Matters\",\"People &amp; 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