{"id":45594,"date":"2021-12-22T10:00:00","date_gmt":"2021-12-22T09:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=45594"},"modified":"2024-03-22T15:17:23","modified_gmt":"2024-03-22T14:17:23","slug":"embl-iab-collaboration-on-the-rise","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/embl-iab-collaboration-on-the-rise\/","title":{"rendered":"EMBL-IAB collaboration on the rise"},"content":{"rendered":"\n

The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB)<\/a> a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.<\/p>\n\n\n\n

New grants to study non-coding RNAs<\/strong><\/h2>\n\n\n\n

Researchers from EMBL Grenoble and IAB recently received funding from the R\u00e9gion Auvergne-Rh\u00f4ne-Alpes (AuRA) and from FINOVI \u2013 a foundation which supports infectious diseases research in France \u2013 to carry out studies on long non-coding RNA (lncRNA) involved in cancer suppression and viral infections.<\/p>\n\n\n\n

These highly collaborative projects \u2013 the first to be funded within the framework of the MoU \u2013 will involve research groups and facilities from EMBL sites in Grenoble and Heidelberg, and structural biology infrastructure from the EPN campus. They will also leverage translational and clinical expertise through IAB and its collaboration with the Grenoble Alpes University Hospital (CHU).<\/p>\n\n\n\n

The AuRA grant specifically funds collaborative projects between local institutions and international partners located in strategic geographical areas defined by the French government, in this case the Baden-Wuerttemberg region of Germany, where EMBL Heidelberg is situated.<\/p>\n\n\n\n

\u201cBy attributing this grant, AuRA and FINOVI appreciate the role that EMBL Heidelberg will play as a strategic partner of regional scientific centres in Grenoble by adding value through the use of three core facilities: Genomics, Proteomics, and Advanced Light Microscopy,” explained EMBL Grenoble group leader Marco Marcia, who leads the project together with the IAB researcher Andr\u00e9 Verdel. \u201cThe involvement of facilities at IAB and EMBL showcases very well the interdisciplinarity and societal relevance of joining the research programmes of the two institutes.\u201d<\/p>\n\n\n\n

Through the two EMBL-IAB research projects, scientists will investigate MEG3<\/a>, a very large RNA that influences the activity of the protein p53 \u2013 a key regulator of cell proliferation. The researchers will look at how MEG3, by stimulating p53, could potentially prevent cancer development and counteract viral infections.<\/p>\n\n\n\n

Meeting of scientific minds<\/strong><\/h2>\n\n\n\n

The new studies are well aligned with common research areas at EMBL and IAB, including epigenetics and infection biology. They also fit well within Grenoble\u2019s research and innovation ecosystem, where several institutes and industries have a well-developed focus on health-related aspects.<\/p>\n\n\n\n

In this respect, the MoU also catalysed the creation of new Grenoble-based scientific clubs to bring researchers in Grenoble together. The Grenoble Host-Pathogen Interactions Club<\/a> and the Grenoble Drug Discovery Club<\/a> follow the model of the existing Grenoble Epigenetics Club<\/a>. Both clubs launched a series of virtual meetings in 2021, each gathering several hundreds of participants from Grenoble, other areas in France, and beyond. <\/p>\n\n\n\n

A year of fruitful collaboration between both institutes concluded with an EMBL-IAB meeting on 22 November. Bringing in EMBL Rome\u2019s Ana Boskovic as a speaker, the event supported the aim of increasing collaboration between IAB and all EMBL sites. \u201cThis inspiring meeting highlighted both long-running and new collaborations between the institutes, paving the way for more jointly funded projects,\u201d said Head of EMBL Grenoble Stephen Cusack.<\/p>\n\n\n\n

\n\n\n\n

Une collaboration en plein essor<\/h1>\n\n\n\n

Retour sur une riche ann\u00e9e de collaboration entre l\u2019EMBL et l\u2019IAB<\/h2>\n\n\n\n

La signature du protocole d’entente <\/a>entre l’EMBL et l’Institute for Advanced Biosciences (IAB), il y a de cela un an, a d\u00e9j\u00e0 permis d\u2019obtenir de nouvelles subventions pour des projets de recherche communs li\u00e9s \u00e0 la biologie du cancer et des infections. Plus g\u00e9n\u00e9ralement, elle a permis l’approfondissement des activit\u00e9s de collaboration entre les deux instituts.<\/p>\n\n\n\n

De nouvelles subventions pour l’\u00e9tude des ARN non-codants<\/strong><\/h2>\n\n\n\n

Des chercheurs de l’EMBL Grenoble et de l’IAB ont r\u00e9cemment re\u00e7u des financements de la R\u00e9gion Auvergne-Rh\u00f4ne-Alpes (AuRA) et de la fondation FINOVI, qui soutient la recherche sur les maladies infectieuses en France. Leurs \u00e9tudes porteront sur les longs ARN non-codants, impliqu\u00e9s dans la suppression du cancer et des infections virales. <\/p>\n\n\n\n

Ces projets hautement collaboratifs sont les premiers \u00e0 \u00eatre financ\u00e9s dans le cadre du protocole d\u2019entente. Ils impliqueront des groupes de recherche et des installations des sites de l’EMBL \u00e0 Grenoble et \u00e0 Heidelberg, ainsi que des infrastructures en biologie structurale du campus EPN \u00e0 Grenoble. Ils tireront \u00e9galement parti de l’expertise clinique et translationnelle de l’IAB, gr\u00e2ce \u00e0 sa collaboration avec le Centre Hospitalier Universitaire Grenoble Alpes. <\/p>\n\n\n\n

La subvention de la R\u00e9gion Auvergne-Rh\u00f4ne-Alpes permet de financer plus sp\u00e9cifiquement des projets de collaboration entre des institutions locales et des partenaires internationaux, situ\u00e9s dans des zones g\u00e9ographiques strat\u00e9giques pour la r\u00e9gion, telle que la r\u00e9gion du Bade-Wurtemberg en Allemagne o\u00f9 se trouve l’EMBL Heidelberg. <\/p>\n\n\n\n

“En attribuant ces financements, la R\u00e9gion Auvergne-Rh\u00f4ne-Alpes et FINOVI appr\u00e9cient le r\u00f4le que le site de l\u2019EMBL \u00e0 Heidelberg joue en tant que partenaire strat\u00e9gique des centres scientifiques r\u00e9gionaux de Grenoble. Il apportera une valeur ajout\u00e9e gr\u00e2ce \u00e0 l’utilisation de trois services scientifiques centraux: les plateformes de G\u00e9nomique, Prot\u00e9omique et de Microscopie optique de pointe”, explique Marco Marcia, chef de groupe \u00e0 l’EMBL Grenoble, qui dirige le projet avec Andr\u00e9 Verdel, chercheur \u00e0 l’IAB. “L’implication des installations de l’IAB et de l’EMBL montre tr\u00e8s bien l’interdisciplinarit\u00e9 et la pertinence soci\u00e9tale des programmes de recherche des deux instituts.”<\/p>\n\n\n\n

Dans le cadre de ces deux projets de recherche entre l\u2019EMBL et l\u2019IAB, les scientifiques \u00e9tudieront MEG3<\/a>, un long ARN qui influence l’activit\u00e9 de la prot\u00e9ine p53, un r\u00e9gulateur cl\u00e9 de la prolif\u00e9ration cellulaire. Les chercheurs \u00e9tudieront comment MEG3, en stimulant p53, pourrait potentiellement pr\u00e9venir le d\u00e9veloppement de cancers et contrer les infections virales.<\/p>\n\n\n\n

Rencontres scientifiques<\/strong><\/h2>\n\n\n\n

Ces nouvelles \u00e9tudes s’inscrivent dans des domaines de recherche communs \u00e0 l’EMBL et \u00e0 l’IAB, particuli\u00e8rement l’\u00e9pig\u00e9n\u00e9tique et la biologie des infections. Elles s’inscrivent \u00e9galement fortement dans l’\u00e9cosyst\u00e8me de recherche et d’innovation \u00e0 Grenoble, o\u00f9 plusieurs instituts et industries s’int\u00e9ressent de pr\u00e8s au domaine de la sant\u00e9. <\/p>\n\n\n\n

\u00c0 cet \u00e9gard, le protocole d’entente a \u00e9galement catalys\u00e9 la cr\u00e9ation de deux nouveaux clubs scientifiques grenoblois destin\u00e9s \u00e0 rassembler les chercheurs de la r\u00e9gion. Le club de Grenoble sur les Int\u00e9ractions h\u00f4te-pathog\u00e8ne<\/a> et le club de Grenoble sur la D\u00e9couverte de m\u00e9dicaments<\/a>, qui suivent le mod\u00e8le du club de Grenoble sur l’\u00c9pig\u00e9n\u00e9tique<\/a>. Les deux clubs ont lanc\u00e9 une s\u00e9rie de r\u00e9unions virtuelles en 2021, chacune rassemblant plusieurs centaines de participants de Grenoble, mais \u00e9galement d’autres r\u00e9gions de France et d’ailleurs. <\/p>\n\n\n\n

Cette riche ann\u00e9e de collaboration s’est achev\u00e9e par un s\u00e9minaire entre les chercheurs de l\u2019EMBL et de l\u2019IAB, le 22 novembre dernier. Ana Boskovic, chef de groupe \u00e0 l’EMBL Rome, figurait parmi les intervenant(e)s de cet \u00e9v\u00e9nement, renfor\u00e7ant ainsi la collaboration entre l’IAB et les diff\u00e9rents sites de l’EMBL. “Cette r\u00e9union a \u00e9t\u00e9 tr\u00e8s stimulante. Elle a mis en lumi\u00e8re de longues collaborations entre les instituts, d’autres plus r\u00e9centes, et ouvre la voie \u00e0 davantage de projets de financement conjoints”, a d\u00e9clar\u00e9 Stephen Cusack, responsable de l’EMBL Grenoble.<\/p>\n","protected":false},"excerpt":{"rendered":"

The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.<\/p>\n","protected":false},"author":104,"featured_media":45628,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17595,3],"tags":[38,474,916,37,3684,547,991,35,3686],"embl_taxonomy":[9792,1802],"class_list":["post-45594","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-connections","category-lab-matters","tag-cancer","tag-collaboration","tag-france","tag-grenoble","tag-infection-biology","tag-marcia","tag-partnership","tag-structural-biology","tag-virology","embl_taxonomy-embl-grenoble","embl_taxonomy-institutional-collaborations"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"","article_intro":"

Looking back at a fruitful year of the two institutes working together<\/p>\n","related_links":[{"link_description":"From molecules to ecosystems: EMBL and IAB sign memorandum of understanding","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/embl-and-iab-sign-memorandum-of-understanding\/"},{"link_description":"MEG3 kissing loops essential for tumour suppression","link_url":"https:\/\/www.embl.org\/news\/science\/kissing-loops-in-lncrna\/"},{"link_description":"Grenoble Epigenetics Club","link_url":"https:\/\/epigenetics.fr\/"},{"link_description":"Grenoble Host-Pathogen Interactions Club","link_url":"https:\/\/hostpathogen.fr\/"},{"link_description":"Grenoble Drug Discovery Club","link_url":"https:\/\/grenobledrugdiscovery.fr\/"},{"link_description":"Institute for Advanced Biosciences 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