{"id":4494,"date":"2015-07-09T11:57:50","date_gmt":"2015-07-09T09:57:50","guid":{"rendered":"http:\/\/news.embl.de\/?p=4494"},"modified":"2024-04-19T15:09:10","modified_gmt":"2024-04-19T13:09:10","slug":"1507-eucys","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/","title":{"rendered":"The germ of a network biologist"},"content":{"rendered":"\n<p>\u201cInteractions: that\u2019s what I like the most in biology,\u201d says Jano\u0161\u00edk, turning his head from his laptop screen that displays a powerpoint full of graphs and microscopy images. He is 19, from Slovakia, and obtained the special prize in molecular and cellular biology at EUCYS 2014, a distinguished annual competition between hundreds of candidates from across Europe. The award recognised his research on mitochondrial DNA stabilisation, which Jano\u0161\u00edk explains enthusiastically.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image alignnone size-full wp-image-4498\"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"380\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-microscope.jpg\" alt=\"Lens on life: Microscope  Jano\u0161\u00edk used in his EUCYS-awarded experiments. PHOTO: Luk\u00e1\u0161 Jano\u0161\u00edk\" class=\"wp-image-4498\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-microscope.jpg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-microscope-300x184.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">Lens on life: Microscope Jano\u0161\u00edk used in his EUCYS-awarded experiments. PHOTO: Luk\u00e1\u0161 Jano\u0161\u00edk<\/figcaption><\/figure>\n\n\n\n<p>Mitochondria are the energy factories of eukaryotic cells (in humans and all animals, plants, mushrooms and many microorganisms). These organelles keep their own DNA, which encodes mitochondrial proteins \u2013 in the first steps of evolution, mitochondria were autonomous bacteria that got engulfed inside other cells and remained there. Growing research highlights that mitochondrial dysfunction is an underlying cause in several human diseases. During a summer spent at Comenius University in Bratislava, Jano\u0161\u00edk investigated a protein that packages mitochondrial DNA in yeast, and found that, strikingly considering its critical function, yeast lives longer when this protein is lacking. Jano\u0161\u00edk thinks that this reflects the activation of a defence response to stress, to counteract the accumulation of miss-folded proteins. \u201cWhen this protein is lacking, other non-mitochondrial proteins with which it interacts begin to accumulate in a miss-folded state,\u201d he explains. \u201cThis triggers the production of molecular chaperones \u2013proteins that help other proteins to fold correctly \u2013 and proteases that destroy miss-folded proteins and protect from oxidative stress. Thus, aging processes are slowed, and that might explain why longevity is extended.\u201d<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image alignnone size-full wp-image-4499\"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"380\" class=\"vf-figure__image\" src=\"http:\/\/news.embl.de\/wp-content\/uploads\/2015\/07\/1507-eucys-petri.jpg\" alt=\"Aging process is slowed in yeast studied by Jano\u0161\u00edk. PHOTO: Luk\u00e1\u0161 Jano\u0161\u00edk\" class=\"wp-image-4499\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-petri.jpg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-petri-300x184.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">Aging process is slowed in yeast studied by Jano\u0161\u00edk. PHOTO: Luk\u00e1\u0161 Jano\u0161\u00edk<\/figcaption><\/figure>\n\n\n\n<p>Every year,&nbsp;<a href=\"http:\/\/news.embl.de\/lab-matters\/1410_eucys\/\">the winner of the EUCYS competition visits EMBL<\/a> to experience the laboratory, its facilities and international environment first hand. During his visit, Jano\u0161\u00edk met several group leaders, postdocs and PhD students: \u201cEMBL is amazing, I would love to do my PhD here,\u201d he says. The prize-winner\u2019s visit is timed to coincide with an event at EMBL\u2019s Advanced Training Centre, and so Jano\u0161\u00edk had the opportunity to attend his first scientific conference, the EMBO\/EMBL symposia \u2018<a href=\"http:\/\/www.embo-embl-symposia.org\/symposia\/2015\/EES15-03\/\" target=\"_blank\" rel=\"noopener noreferrer\">Mechanisms of Neurodegeneration<\/a>\u2019. Although far from his area of expertise, Jano\u0161\u00edk wasted no time in finding a potential link with his previous research: \u201cSome talks and posters suggested that the very same defensive mechanism I think has increased yeast longevity in my experiments may also have a role in the progression of Alzheimer\u2019s disease,\u201d he says.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>EMBL is amazing, I&#8217;d love to do my PhD here<\/p><\/blockquote>\n\n\n\n<p>Jano\u0161\u00edk has an insatiable curiosity that extends far beyond mitochondrial DNA. He is also fascinated by the world of orchids and their evolution and ecological relationships with other species. \u201cOrchids and bees have co-evolved to the extent that only certain species of bee pollinate certain species of orchid,\u201d he explains. Orchid diversity and extinction risk in Europe was the topic of his very first science-related success years ago: together with his sister, he prepared a project that won a local science competition. Jano\u0161\u00edk has gone on to receive awards at other local and national science contests in Slovakia, and international competitions such as the Intel International Science and Engineer Fair and the International Biology Olympiad.<\/p>\n\n\n\n<p>Jano\u0161\u00edk is keeping his options open for the future: \u201cRight now, I want to confirm my hypothesis and investigate the molecular mechanism causing the increased yeast longevity I observed,\u201d he says. Then, he will enroll at the Charles University in Prague to study Biology. It&#8217;s not hard to imagine him returning to EMBL in a few years, presenting new, fascinating and outstanding research as an established life scientist.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cInteractions: that\u2019s what I like the most in biology\u201d \u2013 meet Luk\u00e1\u0161 Jano\u0161\u00edk, EUCYS 2014 prize winner.<\/p>\n","protected":false},"author":28,"featured_media":4497,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3,17593],"tags":[210,60,27],"embl_taxonomy":[],"class_list":["post-4494","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lab-matters","category-people-perspectives","tag-eucys","tag-science-and-society","tag-training"],"acf":{"article_intro":"<p>Luk\u00e1\u0161 Jano\u0161\u00edk, a winner in last year\u2019s European Union Contest of Young Scientists (EUCYS), visited EMBL Heidelberg for one week in June. Here he shares his research interests and reveals his path to earning such a prestigious award at such an early age.<\/p>\n","related_links":[{"link_description":"EUCYS 2014","link_url":"http:\/\/eucys2014.pl\/"},{"link_description":"Comenius University, Bratislava","link_url":"https:\/\/uniba.sk\/"},{"link_description":"Jano\u0161\u00edk's EUCYS prize-winning research","link_url":"http:\/\/eucys2014.pl\/61\/"},{"link_description":"Intel International Science and Engineer Fair","link_url":"http:\/\/www.intel.com\/content\/www\/us\/en\/education\/competitions\/international-science-and-engineering-fair.html"},{"link_description":"International Biology Olympiad","link_url":"http:\/\/www.ibo-info.org\/"},{"link_description":"Looking for the beauty in science \u2013 2013 EUCYS prize winner visits EMBL","link_url":"http:\/\/news.embl.de\/lab-matters\/1410_eucys\/"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The germ of a network biologist | EMBL<\/title>\n<meta name=\"description\" content=\"\u201cInteractions: that\u2019s what I like the most in biology\u201d \u2013 meet Luk\u00e1\u0161 Jano\u0161\u00edk, EUCYS 2014 prize winner.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The germ of a network biologist | EMBL\" \/>\n<meta property=\"og:description\" content=\"\u201cInteractions: that\u2019s what I like the most in biology\u201d \u2013 meet Luk\u00e1\u0161 Jano\u0161\u00edk, EUCYS 2014 prize winner.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-07-09T09:57:50+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-04-19T13:09:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Jos\u00e9 Viosca\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@jviosca\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jos\u00e9 Viosca\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/\"},\"author\":{\"name\":\"Jos\u00e9 Viosca\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/09e8fef149161aed0f9562a51f714c36\"},\"headline\":\"The germ of a network biologist\",\"datePublished\":\"2015-07-09T09:57:50+00:00\",\"dateModified\":\"2024-04-19T13:09:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/\"},\"wordCount\":622,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/lab-matters\/1507-eucys\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/07\/1507-eucys-ib.jpg\",\"keywords\":[\"eucys\",\"science and society\",\"training\"],\"articleSection\":[\"Lab Matters\",\"People &amp; 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