{"id":44902,"date":"2021-12-07T11:00:00","date_gmt":"2021-12-07T10:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=44902"},"modified":"2024-03-22T15:19:29","modified_gmt":"2024-03-22T14:19:29","slug":"how-structural-biology-helps-to-make-rna-vaccines","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/","title":{"rendered":"How structural biology helps to make RNA vaccines"},"content":{"rendered":"\n<div class=\"vf-embed vf-embed--16x9 | vf-u-margin__bottom--400\">\n<iframe src=\"https:\/\/www.youtube.com\/embed\/bQFmvA464J4\" frameborder=\"0\" controls allowfullscreen><\/iframe><\/div>\n\n  \n<figcaption class=\"vf-figure__caption vf-u-margin__top--200\">Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains how a structural biology technique called SAXS contributes to the development of new RNA vaccines.<\/figcaption>\n\n\n\n\n\n<p>RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. They contain&nbsp;messenger RNA (mRNA), an instruction-carrying molecule that tells a cell to make a specific protein. To ensure RNA is delivered to human cells, RNA molecules are placed inside little droplets of fat, called lipid nanoparticles, which protect them. Cells take up the RNA and start to produce the pathogen\u2019s protein. This lasts only for a short time because the RNA is soon degraded. The RNA and its resulting protein do not make a person ill but are sufficient to train the immune system to recognise and destroy the pathogen. Interestingly, this method can be used to gain immunity not only to bacterial and viral infections but also to certain types of cancer.<\/p>\n\n\n\n<p>Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines and how structural biology contributes to its development. He and his colleagues in the Svergun Group specialise in a method called <a href=\"https:\/\/www.embl.org\/news\/science\/saxs-explained\/\">small-angle X-ray scattering (SAXS)<\/a>, which allows them to study the molecular structure of particles directly in solution. Using SAXS, they are able to monitor the shape of lipid nanoparticles in different conditions to make sure they are effective in protecting the RNA and release it only upon entering human cells.&nbsp;<\/p>\n\n\n\n<p>The Svergun Group collaborated on several projects focusing on lipid nanoparticles used for RNA vaccines. Among others, <a href=\"https:\/\/biontech.de\/\">BioNTech<\/a>, the biotech company that together with Pfizer released one of the first COVID-19 vaccines, conducted studies on how RNA can be better packaged and delivered into human cells using the <a href=\"https:\/\/www.embl.org\/groups\/small-angle-x-ray-scattering\/\">EMBL Hamburg\u2019s beamline P12<\/a>. The results of their research are available in <a href=\"https:\/\/www.embl.org\/news\/science\/biontech-uni-mainz-embl-hamburg\/\">several publications<\/a>, published together with<a href=\"https:\/\/www.uni-mainz.de\/eng\/\"> Johannes Gutenberg University Mainz<\/a>,<a href=\"https:\/\/english.tau.ac.il\/\"> Tel Aviv University<\/a>,<a href=\"https:\/\/www.universiteitleiden.nl\/en\"> Leiden University<\/a>, and<a href=\"https:\/\/www.fz-juelich.de\/portal\/EN\/Home\/home_node.html\"> Forschungszentrum J\u00fclich<\/a>.<\/p>\n\n\n\n<p>EMBL\u2019s scientific services provide users with access to innovative technologies and high-quality instrumentation, in combination with the scientific and technical expertise of our staff. Providing scientists in academia and industry with access to the latest scientific technologies, infrastructures, and data resources is one of the core <a href=\"https:\/\/www.embl.org\/about\/missions\/\">EMBL missions<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines, and how structural biology contributes to its development. EMBL Hamburg collaborated on several&hellip;<\/p>\n","protected":false},"author":96,"featured_media":45152,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[726,91,1025,1331,53,71,11948,3648,17291,70,1329,251,35,250,5658,245],"embl_taxonomy":[9596],"class_list":["post-44902","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-beamline","tag-biotechnology","tag-coronavirus","tag-covid-19","tag-hamburg","tag-industry","tag-lipid-nanoparticles","tag-nanobiotechnology","tag-nanomedicines","tag-rna","tag-sars-cov-2","tag-small-angle-x-ray-scattering-saxs","tag-structural-biology","tag-svergun","tag-vaccine","tag-video","embl_taxonomy-embl-hamburg"],"acf":{"featured":true,"show_featured_image":true,"field_target_display":"","article_intro":"<p>EMBL Hamburg\u2019s expertise in small-angle X-ray scattering helps to develop new RNA vaccines<\/p>\n","related_links":[{"link_description":"Svergun Group","link_url":"https:\/\/www.embl.org\/groups\/svergun\/"},{"link_description":"Swordfish sword under X-rays: SAXS explained","link_url":"https:\/\/www.embl.org\/news\/science\/saxs-explained\/"},{"link_description":"EMBL facilities support development of RNA vaccines","link_url":"https:\/\/www.embl.org\/news\/science\/biontech-uni-mainz-embl-hamburg\/"},{"link_description":"Shining high-brilliance beams on coronavirus structure","link_url":"https:\/\/www.embl.org\/news\/science\/shining-high-brilliance-beams-on-coronavirus-structure\/"},{"link_description":"EMBL scientific services","link_url":"https:\/\/www.embl.org\/services-facilities\/"}],"source_article":false,"in_this_article":false,"press_contact":"None","field_article_language":{"value":"english","label":"English"},"article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"613c4de5-1775-447f-af71-4b07085318e9\";}","parents":[],"name":["EMBL Hamburg"],"slug":"embl-hamburg","description":"Where &gt; All EMBL sites &gt; EMBL Hamburg"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How structural biology helps to make RNA vaccines | EMBL<\/title>\n<meta name=\"description\" content=\"EMBL Hamburg\u2019s expertise in structural biology method called small-angle X-ray scattering helps to develop new RNA vaccines.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How structural biology helps to make RNA vaccines | EMBL\" \/>\n<meta property=\"og:description\" content=\"EMBL Hamburg\u2019s expertise in structural biology method called small-angle X-ray scattering helps to develop new RNA vaccines.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-12-07T10:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T14:19:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2021\/12\/Thumbnail-for-website.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Dorota Badowska\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@d_badowska\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Dorota Badowska\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/\"},\"author\":{\"name\":\"Dorota Badowska\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/b8ae50efcd7533f0ab2ec368736b1d04\"},\"headline\":\"How structural biology helps to make RNA vaccines\",\"datePublished\":\"2021-12-07T10:00:00+00:00\",\"dateModified\":\"2024-03-22T14:19:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/\"},\"wordCount\":354,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-structural-biology-helps-to-make-rna-vaccines\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2021\/12\/Thumbnail-for-website.jpg\",\"keywords\":[\"beamline\",\"biotechnology\",\"coronavirus\",\"covid-19\",\"hamburg\",\"industry\",\"lipid nanoparticles\",\"nanobiotechnology\",\"nanomedicines\",\"rna\",\"sars-cov-2\",\"small-angle x-ray scattering (saxs)\",\"structural biology\",\"svergun\",\"vaccine\",\"video\"],\"articleSection\":[\"Science\",\"Science &amp; 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