{"id":43394,"date":"2021-10-19T15:35:25","date_gmt":"2021-10-19T13:35:25","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=43394"},"modified":"2024-03-22T15:07:10","modified_gmt":"2024-03-22T14:07:10","slug":"cryptic-cataloguing-drug-resistance-mutations-in-m-tuberculosis","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/cryptic-cataloguing-drug-resistance-mutations-in-m-tuberculosis\/","title":{"rendered":"CRyPTIC: cataloguing drug resistance mutations in M. tuberculosis"},"content":{"rendered":"\n<p>In collaboration with colleagues across the world including <a href=\"https:\/\/www.ebi.ac.uk\/\">EMBL\u2019s European Bioinformatics Institute (EMBL-EBI)<\/a>, the <a href=\"http:\/\/www.crypticproject.org\">Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC)<\/a> project has generated the world\u2019s largest data resource for the study of drug resistance in TB.<\/p>\n\n\n\n<p>CRyPTIC aims to reveal the genetic causes of drug resistant TB to enable the development of DNA-based diagnostics. Using a new experimental assay, the consortium has semi-quantitatively measured the level of drug resistance and scanned the genome of over 15,000 <em>Mycobacterium tuberculosis <\/em>(<em>M. tuberculosis)<\/em> strains from across the globe.<\/p>\n\n\n\n<p>Together these form a unique, rich dataset, which can be used to probe the genetic causes of drug resistance in TB. The end goal is to apply these insights to DNA-based diagnostics, predicting the drug resistance of a patient TB strain to different drugs allowing for personalised treatment.<\/p>\n\n\n\n<p>These data are hosted at EMBL-EBI where they will be made freely available to the scientific community.<\/p>\n\n\n\n<a href=\"http:\/\/ftp.ebi.ac.uk\/pub\/databases\/cryptic\/\" target=\"_blank\">\n<button class=\"vf-button vf-button--primary vf-button--sm\">Access the CRyPTIC project data<\/button>\n<\/a>\n<!--\/vf-button-->\n\n\n\n\n\n\n\n\n<h2 class=\"wp-block-heading\">Improving TB treatment<\/h2>\n\n\n\n<p>\u201cTB currently causes over a million deaths per year all across the globe, and appropriate therapy is dependent on identifying which drugs will and won\u2019t work for each patient\u2019s particular infection,&#8221; said <a href=\"https:\/\/www.ebi.ac.uk\/about\/people\/zamin-iqbal\">Zamin Iqbal, Group Leader at EMBL-EBI<\/a>. \u201cDetermining the genetic basis of drug resistant TB enables rapid DNA-based diagnostics for identifying resistance to drugs, and informing therapy choice. By using quantitative measurements, rather than binary yes or no to resistance, we have been able to discern the fine-scale impact of specific mutations on resistance. In the process, this has generated a huge resource for science which we expect to be used for years to come.&#8221;<\/p>\n\n\n\n<p>This work is detailed in nine new studies, covering a range of topics including:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>new approaches to detecting genetic mutations in the <em>M. tuberculosis <\/em>genome<\/li><li>discovering the genetic causes of drug resistance and the precise impact of each mutation<\/li><li>how artificial intelligence can predict drug resistance from DNA signatures<\/li><li>how these data were used to build the new <a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789240028173\">WHO TB resistance catalogue<\/a><\/li><\/ul>\n\n\n\n<p>You can find out more about this work in the preprints listed below.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Find out more&nbsp;<\/strong><\/h2>\n\n\n\n<p>Learn more in this <a href=\"https:\/\/www.ox.ac.uk\/news\/2021-10-19-largest-ever-global-study-tuberculosis-identifies-genetic-causes-drug-resistance\">press release published on the Oxford University website<\/a>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Funding<\/strong><\/h2>\n\n\n\n<p>The CRyPTIC project is funded by the MRC Newton Fund, Wellcome, and the Bill and Melinda Gates Foundation.<\/p>\n\n\n\n<p>This post was originally published on <a href=\"https:\/\/www.ebi.ac.uk\/about\/news\/press-releases\/cryptic-cataloguing-drug-resistance-mutations-m-tuberculosis\" data-href=\"insert original\" rel=\"canonical nofollow noopener noreferrer\" target=\"_blank\">EMBL-EBI News<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Profiling M. tuberculosis strains from 27 countries to reveal causes of drug resistance.<\/p>\n","protected":false},"author":77,"featured_media":43408,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[1345,782,36,315,764],"embl_taxonomy":[2906],"class_list":["post-43394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-data-sharing","tag-database","tag-embl-ebi","tag-open-data","tag-tuberculosis","embl_taxonomy-embl-ebi"],"acf":{"featured":true,"show_featured_image":false,"field_target_display":"embl-ebi","article_intro":"<p>Profiling <em>M. tuberculosis<\/em> strains from 27 countries to reveal causes of drug resistance<\/p>\n","related_links":[{"link_description":"The CRyPTIC project","link_url":"http:\/\/www.crypticproject.org\/"}],"source_article":[{"publication_title":"The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A new global standard for molecular diagnostics","publication_link":{"title":"","url":"http:\/\/www.crypticproject.org\/wp-content\/uploads\/2021\/09\/CRyPTIC9-WHO-preprint.pdf","target":""},"publication_authors":"Walker TM., et al.","publication_source":"WHO preprint","publication_date":"21 September 2021","publication_doi":""},{"publication_title":"Genome-wide association studies of global Mycobacterium tuberculosis resistance to thirteen antimicrobials in 10,228 genomes","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.14.460272v1","target":""},"publication_authors":"The CRyPTIC Consortium ","publication_source":"BioRxiv","publication_date":"16 September 2021","publication_doi":"10.1101\/2021.09.14.460272"},{"publication_title":"A generalisable approach to drug susceptibility prediction for M. Tuberculosis using machine learning and whole-genome sequencing","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.14.458035v1","target":""},"publication_authors":"The CRyPTIC Consortium ","publication_source":"BioRxiv","publication_date":"16 September 2021","publication_doi":"10.1101\/2021.09.14.458035"},{"publication_title":"Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.14.460353v1","target":""},"publication_authors":"The CRyPTIC Consortium ","publication_source":"BioRxiv","publication_date":"16 September 2021","publication_doi":"10.1101\/2021.09.14.460353"},{"publication_title":"Epidemiological cutoff values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis","publication_link":{"title":"","url":"https:\/\/www.medrxiv.org\/content\/10.1101\/2021.02.24.21252386v3","target":""},"publication_authors":"The CRyPTIC Consortium ","publication_source":"MedRxiv","publication_date":"16 September 2021","publication_doi":"10.1101\/2021.02.24.21252386"},{"publication_title":"A data compendium of Mycobacterium tuberculosis antibiotic resistance","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.14.460274v2","target":""},"publication_authors":"Brankin A., et al.","publication_source":"BioRxiv","publication_date":"16 September 2021","publication_doi":"10.1101\/2021.09.14.460274"},{"publication_title":"BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.07.20.453060v3","target":""},"publication_authors":"Fowler PW., et al.","publication_source":"BioRxiv","publication_date":"13 September 2021","publication_doi":"10.1101\/2021.07.20.453060"},{"publication_title":"Minos: variant adjudication and joint genotyping of cohorts of bacterial genomes","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.09.15.460475v1","target":""},"publication_authors":"Hunt M., et al.","publication_source":"BioRxiv","publication_date":"15 September 2021","publication_doi":"10.1101\/2021.09.15.460475"},{"publication_title":"Deciphering Bedaquiline and Clofazimine Resistance in Tuberculosis: An Evolutionary Medicine Approach","publication_link":{"title":"","url":"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.19.436148v4","target":""},"publication_authors":"Sonnenkalb L., et al.","publication_source":"BioRxiv","publication_date":"13 September 2021","publication_doi":"10.1101\/2021.03.19.436148"}],"in_this_article":false,"press_contact":"None","vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"a99d1a7c-ca83-4c00-ab61-d082d3e41ce3\";}","parents":[],"name":["EMBL-EBI"],"slug":"embl-ebi","description":"Where &gt; 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