{"id":41762,"date":"2021-10-05T10:00:00","date_gmt":"2021-10-05T08:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=41762"},"modified":"2024-03-22T15:00:58","modified_gmt":"2024-03-22T14:00:58","slug":"platybrowser","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/platybrowser\/","title":{"rendered":"A cellular atlas of an entire worm"},"content":{"rendered":"\n

Multicellular organisms, such as plants, animals, and humans, consist of various tissues and cell types that each have their own specific function. Their specialisation is orchestrated by the expression of particular gene combinations, which leads to the formation of different subcellular structures. But how well do gene expression patterns and subcellular structures correlate in a multicellular organism? EMBL scientists have addressed this question in the marine worm Platynereis dumerilii<\/em>, creating the first multimodal cellular atlas<\/a> combining electron microscopy and expression data for an entire animal.<\/p>\n\n\n\n

\u201cThis is the first time such a detailed dataset directly correlating data on cell-by-cell gene expression and subcellular morphology has been obtained for an entire animal,\u201d says Detlev Arendt, EMBL Group Leader and Senior Scientist, who coordinated the research together with his EMBL colleagues Christian Tischer, Yannick Schwab, and Anna Kreshuk, and external collaborator Rainer Friedrich at the Friedrich Miescher Institute for Biomedical Research (FMI) in Basel, Switzerland.<\/p>\n\n\n\n

\u201cTo make the data accessible to the community, we developed an open-source plugin for the popular image analysis software Fiji<\/em>. Initially we called this plugin the PlatyBrowser, but it soon turned out to be a very useful generic tool for multimodal big image data sharing and exploration, and we thus now call it MoBIE<\/a>,\u201d explains Christian Tischer, Scientist \/ IT Engineer in EMBL\u2019s Centre for Bioimage Analysis.<\/p>\n\n\n\n

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