{"id":3722,"date":"2015-04-15T18:06:48","date_gmt":"2015-04-15T16:06:48","guid":{"rendered":"http:\/\/news.embl.de\/?p=3722"},"modified":"2024-11-14T16:26:20","modified_gmt":"2024-11-14T15:26:20","slug":"1504-lilbubome","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/","title":{"rendered":"Curiosity created the ‘Bubome"},"content":{"rendered":"\n

By Uschi Symmons<\/h3>\n\n\n\n

I\u2019ve been busy setting up a new project with two friends (and former collaborators) of mine: to sequence the genome of Lil Bub, an Internet celebrity cat \u2013 with the help of crowdfunding. We\u2019ve christened the project theLilBubome, and after many months of preparation we\u2019ve finally launched our blog<\/a>, our twitter account<\/a> and our facebook page<\/a>. The crowdfunding<\/a> started today.<\/p>\n\n\n\n

\"blog_logov2\"<\/figure>\n\n\n\n

It\u2019s a project I\u2019m incredibly excited about for many reasons:<\/p>\n\n\n\n

The science is cool\u2026<\/h3>\n\n\n\n

Lil Bub is not just an Internet celebrity cat. First she\u2019s more than cute cat photos and viral youtube videos \u2013 she also uses her fame to raise money for pets with special needs. Moreover, she\u2019s got a bunch of fascinating traits: she\u2019s tiny, she has polydactyly (extra toes on all her paws), her lower jaw is very small (which is why you can see her tongue hanging out on most of her pictures), she has no teeth and she has a rare bone defect, diagnosed as osteopetrosis. Each of these traits on its own has been seen before in human patients and in other animals, including mice that I studied during my PhD<\/a>. But the combination of these traits is unique, so sequencing Lil Bub\u2019s genome might help us decide if she just has a very unusual form of a disease (for example osteopetrosis), or if she\u2019s just unlucky, and was actually born with multiple rare diseases.<\/p>\n\n\n\n

With the LilBubome we hope to attract a broader audience: people who might not care about science and genetics, but who do care about Lil Bub and what makes her so special<\/p><\/blockquote>\n\n\n\n

Science outreach\u2026<\/h3>\n\n\n\n

Engaging the public in science is something I love to do. But sometimes I feel that with traditional science outreach (interactive science museums, TED Talks, PopSci events) we are preaching to the choir, only reaching people who are already interested in science. With the LilBubome we hope to attract a broader audience: people who might not care about science and genetics, but who do care about Lil Bub and what makes her so special.<\/p>\n\n\n\n

When Angelina Jolie had her breasts and \u2013 more recently \u2013 her fallopian tubes and ovaries removed, many of my non-scientists friends asked me about the genetic test that prompted her decision. Apparently the number of people getting tested for breast cancer increased by 40% after her first op-ed in the New York Times. This has been dubbed the Angelina Jolie effect*. We\u2019re hoping that we can maybe achieve a similar effect (the Bub effect?), inspiring people to learn more about sequencing and the information you can read out of a genome sequence.<\/p>\n\n\n\n

On our blog and various media channels we want to engage with everyone and anyone directly, answer questions and explain what we\u2019re doing in detail.<\/p>\n\n\n\n

Venturing into crowdfunding\u2026<\/h3>\n\n\n\n

The science-funding landscape is changing. Currently national science budgets are decreasing around the globe. Crowdfunding and donations from the public can clearly make a difference; you need only think of last year\u2019s #IceBucketChallenge. There\u2019s a lot of debate among scientists about how crowdfunding should relate to traditional science funding, but I think there is the possibility for peaceful co-existence of the two: It would be difficult to convince any grant-giving organisation to fund the LilBubome. After all, if we wanted to study osteopetrosis or polydactyly there are probably more systematic, experimentally tangible approaches. However, that does not mean it\u2019s not an interesting project or that we\u2019re not curious to unlock the genetic secret behind Lil Bub\u2019s special traits. And if other people think the way we do, we hope that they will vote with their feet. In exchange, we\u2019ll share everything we do in the project, making our research a public good.<\/p>\n\n\n\n

I don\u2019t know if the LilBubome will work out, but I hope it will. If you\u2019re as curious as we are, please do follow us on one of our channels.<\/p>\n\n\n

\n\n\n

*Some have criticised that the Jolie effect was superficial, with many women seeing their doctors to get tested, without actually understanding (or trying to understand) the science behind genetic testing for breast cancer. We hope the Bub effect (if it does happen) will be different, hence our efforts to explain the science behind the project in detail.<\/p>\n","protected":false},"excerpt":{"rendered":"

Exploring the science and magic of Lil Bub \u2013 alumna launches project to sequence the \u2018Lilbubome\u2019.<\/p>\n","protected":false},"author":16,"featured_media":3726,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5,3],"tags":[80,41,42,60],"embl_taxonomy":[],"class_list":["post-3722","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alumni","category-lab-matters","tag-alumni","tag-genetics","tag-genomics","tag-science-and-society"],"acf":{"article_intro":"

Take one celebrity cat, add three curious and candid geneticists, and what do you get? LilBubome: a crowdfunding enterprise co-organised by EMBL alumna Uschi Symmons, whose latest blog post introduces the project.<\/p>\n","related_links":[{"link_description":"Lil BUB\u2019s BIG Fund for the American Society for the Protection of Cruelty to Animals (ASPCA)","link_url":"https:\/\/www.aspca.org\/secure\/lilbub"},{"link_description":"My Medical Choice, Angelina Jolie's op-ed in The New York Times, 14 May 2013","link_url":"http:\/\/www.nytimes.com\/2013\/05\/14\/opinion\/my-medical-choice.html"},{"link_description":"BRCA gene testing rates soar after Angelina Jolie double mastectomy Announcement, AARP Magazine, 11 February 2015","link_url":"http:\/\/www.aarp.org\/about-aarp\/press-center\/info-02-2015\/aarp-report-brca-testing-jolie-effect.html"},{"link_description":"The Angelina effect should be about knowing your cancer risk, Science News, 10 April 2015","link_url":"https:\/\/www.sciencenews.org\/blog\/culture-beaker\/angelina-effect-should-be-about-knowing-your-cancer-risk"},{"link_description":"LilBubome blog","link_url":"https:\/\/lilbubome.wordpress.com\/"},{"link_description":"@LilBubome on Twitter","link_url":"https:\/\/twitter.com\/lilbubome"},{"link_description":"Lilbubome on Facebook","link_url":"https:\/\/www.facebook.com\/pages\/LilBubome\/1680147055545516"},{"link_description":"Lilbubome crowdfunding on experiment.com","link_url":"https:\/\/experiment.com\/projects\/the-lilbubome-sequencing-lilbub-s-magical-genome"}],"article_sources":[{"source_description":"

This post was originally published on Uschi’s blog, Pasteur\u2019s Quadrant<\/em>, 11 April 2015<\/p>\n","source_link_url":"https:\/\/pasteursquadrant.wordpress.com\/2015\/04\/11\/towards-new-horizons-sequencing-lil-bubs-genome-through-crowdfunding\/"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"\nCuriosity created the 'Bubome | EMBL<\/title>\n<meta name=\"description\" content=\"Exploring the science and magic of Lil Bub \u2013 alumna launches project to sequence the \u2018Lilbubome\u2019.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Curiosity created the 'Bubome | EMBL\" \/>\n<meta property=\"og:description\" content=\"Exploring the science and magic of Lil Bub \u2013 alumna launches project to sequence the \u2018Lilbubome\u2019.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-04-15T16:06:48+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-14T15:26:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/04\/1504-lilbub-ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Guest author(s)\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Guest author(s)\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\"},\"author\":{\"name\":\"Guest author(s)\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b\"},\"headline\":\"Curiosity created the ‘Bubome\",\"datePublished\":\"2015-04-15T16:06:48+00:00\",\"dateModified\":\"2024-11-14T15:26:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\"},\"wordCount\":725,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/04\/1504-lilbub-ib.jpg\",\"keywords\":[\"alumni\",\"genetics\",\"genomics\",\"science and society\"],\"articleSection\":[\"Alumni\",\"Lab Matters\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\",\"url\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\",\"name\":\"Curiosity created the 'Bubome | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/04\/1504-lilbub-ib.jpg\",\"datePublished\":\"2015-04-15T16:06:48+00:00\",\"dateModified\":\"2024-11-14T15:26:20+00:00\",\"description\":\"Exploring the science and magic of Lil Bub \u2013 alumna launches project to sequence the \u2018Lilbubome\u2019.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/alumni\/1504-lilbubome\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/04\/1504-lilbub-ib.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/04\/1504-lilbub-ib.jpg\",\"width\":620,\"height\":425,\"caption\":\"Lil Bub is an Internet sensation: book author, filmstar and even TV host. 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