{"id":36302,"date":"2021-02-16T12:17:52","date_gmt":"2021-02-16T11:17:52","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=36302"},"modified":"2024-03-22T14:16:31","modified_gmt":"2024-03-22T13:16:31","slug":"coronavirus-helper-proteins","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/coronavirus-helper-proteins\/","title":{"rendered":"Finding coronavirus\u2019s helper proteins"},"content":{"rendered":"\n

A group of scientists led by EMBL\u2019s Mikhail Savitski, Nassos Typas, and Pedro Beltrao, and collaborator Steeve Boulant at Heidelberg University Hospital, have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.<\/p>\n\n\n\n

The researchers used a biophysical method called thermal proteome profiling (TPP) to gain a comprehensive overview of which human proteins are functionally altered during SARS-CoV-2 infection. TPP monitors protein amounts and denaturation temperatures \u2013 the points at which proteins heat up so much that they lose their 3D structure. A shift in denaturation temperature indicates that a particular protein has undergone a functional change upon infection, possibly due to the virus hijacking the protein for use in its own replication.<\/p>\n\n\n\n

The scientists observed that infection with SARS-CoV-2 changed the abundance and thermal stability of hundreds of cellular proteins. This included thermal stability changes in proteins required to maintain the cytoskeleton \u2013 a protein network that maintains cell shape and stability \u2013 and a group of proteins called heat shock chaperones: proteins that take care of unfolded or misfolded proteins and help them to maintain their 3D structure.<\/p>\n\n\n\n

Having identified candidate proteins and cellular processes that SARS-CoV-2 may hijack to promote its replication, the scientists used drugs to inhibit some of the host proteins that SARS-CoV-2 appeared to be exploiting. This resulted in a strong reduction in viral replication in the presence of two of the tested compounds, demonstrating their potential as antiviral therapeutics. The scientists believe that other proteins they identified could be targeted in a similar way to block SARS-CoV-2 proliferation.<\/p>\n\n\n\n

The study was a collaborative effort, involving the Savitski team<\/a> and Typas group<\/a> in EMBL Heidelberg\u2019s Genome Biology Unit<\/a>, EMBL\u2019s Proteomics Core Facility<\/a>, the Beltrao group<\/a> at EMBL\u2019s European Bioinformatics Institute (EMBL-EBI), the Boulant lab<\/a> and colleagues from Heidelberg University Hospital, the German Cancer Research Center (DKFZ), and the Technical University of Munich. As well as gaining new insights into SARS-CoV-2 biology, the researchers were also able to expand the scope of the TPP methodology by adapting it to work with infectious samples under high biosafety conditions. This enables them to quickly analyse the effects of dangerous pathogens on the cell\u2019s proteins.<\/p>\n","protected":false},"excerpt":{"rendered":"

A team of EMBL scientists and colleagues have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.<\/p>\n","protected":false},"author":81,"featured_media":36312,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[442,227,1025,1331,36,496,43,842,45,1329,434,669,582],"embl_taxonomy":[2278,5146,3750,19371,19391],"class_list":["post-36302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-beltrao","tag-core-facility","tag-coronavirus","tag-covid-19","tag-embl-ebi","tag-genome-biology","tag-heidelberg","tag-hinxton","tag-proteomics","tag-sars-cov-2","tag-savitski","tag-thermal-proteome-profiling","tag-typas","embl_taxonomy-covid-19","embl_taxonomy-genome-biology","embl_taxonomy-proteomics-core-facility","embl_taxonomy-savitski-team","embl_taxonomy-typas-group"],"acf":{"featured":true,"show_featured_image":false,"color":"#193f90","link_color":"#fff","article_intro":"

EMBL scientists identify human proteins hijacked by coronavirus, offering potential drug targets<\/p>\n","related_links":[{"link_description":"EMBL\u2019s contribution to fighting the coronavirus pandemic","link_url":"https:\/\/www.embl.org\/topics\/coronavirus\/"},{"link_description":"Research in the Savitski team","link_url":"https:\/\/www.embl.org\/groups\/savitski\/"},{"link_description":"Research in the Typas group","link_url":"https:\/\/www.embl.org\/groups\/typas\/"},{"link_description":"Research in the Beltrao group","link_url":"https:\/\/www.ebi.ac.uk\/research-beta\/beltrao\/"},{"link_description":"Research in the Genome Biology Unit","link_url":"https:\/\/www.embl.org\/research\/units\/genome-biology\/"},{"link_description":"EMBL's Proteomics Core Facility","link_url":"https:\/\/www.embl.org\/groups\/proteomics\/"},{"link_description":"Heating proteins to understand how genes work","link_url":"https:\/\/www.embl.org\/news\/science\/heating-proteins-to-understand-how-genes-work\/"}],"article_sources":[{"source_description":"

Joel Selkrig, Megan Stanifer, Andr\u00e9 Mateus, Karin Mitosch, Inigo Barrio-Hernandez, Mandy Rettel et al.<\/em> SARS-CoV-2 infection remodels the host protein thermal stability landscape. Molecular Systems Biology<\/em>, published online 16 February 2021. DOI: 10.15252\/msb.202010188<\/p>\n","source_link_url":"https:\/\/www.embopress.org\/doi\/10.15252\/msb.202010188"}],"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"None","vf_locked":false,"field_target_display":"embl","source_article":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"a5d0c484-f12a-4a27-93cc-85e3a6d79c09\";i:2;s:36:\"5683518e-43cd-4740-8583-31a65ef324d3\";}","parents":[],"name":["COVID-19"],"slug":"covid-19","description":"What > Topics > COVID-19"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"7ca3ce91-dc32-47ea-8d4b-7a53c3a3a9fd\";i:2;s:36:\"fe59a59f-fd7d-49b3-b3e4-bdd33a6642c3\";}","parents":[],"name":["Genome Biology"],"slug":"genome-biology","description":"What > Research Units > Genome Biology"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"ef0437fc-a5b7-4c73-bcfd-63bff16cb35e\";i:2;s:36:\"03134396-a6d4-4450-986c-cd806c85f0a7\";}","parents":[],"name":["Proteomics Core Facility"],"slug":"proteomics-core-facility","description":"What > Services and facilities > Proteomics Core Facility"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"bd910dd7-0cda-4618-8bfa-d37fbda8438e\";i:2;s:36:\"b75f6f46-874c-40e5-a44f-a2bc5b173198\";}","parents":[],"name":["Savitski Team"],"slug":"savitski-team","description":"What > Molecular Systems Biology > Savitski Team"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"bd910dd7-0cda-4618-8bfa-d37fbda8438e\";i:2;s:36:\"94ddaf2b-18a5-4239-9017-bb23f22f3e9f\";}","parents":[],"name":["Typas Group"],"slug":"typas-group","description":"What > Molecular Systems Biology > Typas Group"}],"yoast_head":"\nFinding coronavirus\u2019s helper proteins | EMBL<\/title>\n<meta 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