{"id":33768,"date":"2020-11-23T10:00:16","date_gmt":"2020-11-23T09:00:16","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=33768"},"modified":"2025-07-15T12:44:08","modified_gmt":"2025-07-15T10:44:08","slug":"covid-replication","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/covid-replication\/","title":{"rendered":"Replication cycle of SARS-CoV-2 in 3D"},"content":{"rendered":"\n<p>As the global coronavirus pandemic continues, scientists are not only trying to find vaccines and drugs to combat it, but also to continuously learn more about the virus itself. \u201cBy now we can expect the coronavirus to become seasonal,\u201d explains Ralf Bartenschlager, professor in the <a href=\"https:\/\/www.klinikum.uni-heidelberg.de\/zentrum-fuer-infektiologie\/molecular-virology\/\">Department of Infectious Diseases, Molecular Virology, at Heidelberg University<\/a>. \u201cThus, there is an urgent need to develop and implement both prophylactic and therapeutic strategies against this virus.\u201d In a new study, Bartenschlager, assisted by the <a href=\"https:\/\/www.embl.de\/research\/units\/cbb\/schwab\/index.html\">Schwab team at EMBL Heidelberg<\/a> and using <a href=\"https:\/\/www.embl.de\/services\/core_facilities\/em\/\">EMBL\u2019s Electron Microscopy Core Facility<\/a>, performed a detailed imaging analysis to determine how the virus reprograms infected cells.<\/p>\n\n\n\n<p>Cells that become infected by SARS-CoV-2 die rather quickly, within only 24 to 48 hours. This indicates that the virus harms the human cell in such a way that it is rewired and essentially forced to produce viral progeny. The main aim of the project was therefore to identify the morphological changes within a cell that are inherent to this reprogramming. \u201cTo develop drugs which suppress the viral replication and thereby the consequence of the infection, as well as the virus-induced cell death, is key to have a better understanding of the biological mechanisms driving the virus\u2019 replication cycle,\u201d explains Bartenschlager. The team used <a href=\"https:\/\/www.embl.de\/services\/core_facilities\/em\/\">the imaging facilities at EMBL and state-of-the art imaging techniques <\/a>to determine the 3D architecture of SARS-CoV-2-infected cells, as well as alterations of cellular architecture caused by the virus.<\/p>\n\n\n\n<figure class=\"wp-block-embed-youtube wp-block-embed is-type-video is-provider-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"Replication of the coronavirus in 3D\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/JCI0aiveces?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption>Interview with Ralf Bartenschlager and Yannick Schwab.<\/figcaption><\/figure>\n\n\n\n<p>The team was able to create 3D reconstructions of whole cells and their subcellular compartments. \u201cWe are providing critical insights into virus-induced structural changes in the studied human cells,\u201d explains Ralf Bartenschlager. The images revealed an obvious and massive change in the endomembrane systems of the infected cells \u2013 a system that enables the cell to define different compartments and sites. The virus induces membrane changes in such a way that it can produce its own replication organelles. These are mini replication compartments where the viral genome is amplified enormously. To do this, the virus requires membrane surfaces. These are created by exploiting a cellular membrane system and creating an organelle, which has a very distinct appearance. The scientists describe it as a massive accumulation of bubbles: two membrane layers forming a big balloon. Within these balloons \u2013 which form a very shielded compartment \u2013 the viral genomes are multiplied and released to become incorporated into new virus particles.<\/p>\n\n\n\n<p>This striking change can be seen in the cells only a few hours after infection. \u201cWe saw how and where the virus replicates within the cell, and how it hijacks its host machinery to be released after multiplication,\u201d Schwab says. Until now, little was known about the origin and development of the effects that SARS-CoV-2 causes in the human body. This includes a lack of knowledge about the mechanism by which the infection leads to the death of infected cells. Having this information now will foster the development of therapies reducing virus replication and, thus, disease severity.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"600\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1.jpg\" alt=\"\" class=\"wp-image-33782\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1.jpg 1000w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1-300x180.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1-768x461.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><figcaption class=\"vf-figure__caption\">A portion of an infected cell is observed by transmission electron microscopy, in which SARS-CoV-2-specific structures (in red, from the mirrored image on the right) can be detected as early as six hours after infection. The virus\u2019s genome is replicated in high copy number in two membrane layers forming a big balloon (large structures in red), which forms a very shielded compartment. New virions (small structures in red) are being formed by budding at the interface of the endoplasmic reticulum and Golgi apparatus. Credit: Yannick Schwab\/EMBL<\/figcaption><\/figure>\n\n\n\n<p>The team has made sure that the collected information and, in particular, the unprecedented repository of 3D structural information about virus-induced substructures can be used by everyone. \u201cI believe we are setting a precedent on the fact that we are sharing all data that we produced with the scientific community. It represents an impressive resource to the community,\u201d says Yannick Schwab. \u201cThis way we can support the global effort to study how SARS-CoV-2 interacts with its host.\u201d The team hopes that their collected information will help in the development of antiviral drugs.<\/p>\n\n\n\n<p>The team managed to produce the study in an incredibly short time, despite the challenging circumstances. \u201cHalf the world \u2013 and of course Heidelberg as well \u2013 were in full lockdown and we had to improvise almost on a daily basis to adapt to the situation. Whether at EMBL or from home, all were deeply involved and generously gave their time and deep knowledge,\u201d says Schwab. \u201cThe speed at which we worked, and the amount of data that was produced, is remarkable.\u201d<\/p>\n\n\n\n<hr class=\"vf-divider\"\/>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"german\">Replikationszyklus von SARS-COV-2 in 3D<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">Untersuchung wie SARS-CoV-2 die Maschinerien der Wirtszellen \u00fcbernimmt wird dabei helfen therapeutische Strategien zu entwickeln<\/h2>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"600\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/cover-1000x600-2.jpg\" alt=\"\" class=\"wp-image-33868\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/cover-1000x600-2.jpg 1000w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/cover-1000x600-2-300x180.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/cover-1000x600-2-768x461.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"vf-figure__caption\">Infizierte Zellen wurden mittels fokussierter Ionenstrahl-Rasterelektronenmikroskopie abgebildet, einer leistungsstarken Technik, um die Organisation einer Zelle auf subzellul\u00e4rer Ebene in 3D darzustellen. In diesem Bild wurde ein Subvolumen einer Zelle segmentiert, um membrangebundene Organellen (in grau) und Doppelmembran-Vesikel (in rot) darzustellen &#8211; ein virusspezifisches Kompartiment, in dem das virale Genom in gro\u00dfen Mengen repliziert wird. Billdnachweis: Julian Hennies\/EMBL<\/figcaption><\/figure>\n\n\n\n<p>Im Zuge der weltweiten Corona-Pandemie versuchen Wissenschaftler nicht nur Impfstoffe und Medikamente gegen die Krankheit zu finden, sondern auch kontinuierlich mehr \u00fcber das Virus selbst zu erfahren. \u201eInzwischen k\u00f6nnen wir damit rechnen, dass das Coronavirus saisonal wird,\u201c erkl\u00e4rt Ralf Bartenschlager, Professor in der <a href=\"https:\/\/www.klinikum.uni-heidelberg.de\/zentrum-fuer-infektiologie\/molecular-virology\/\">Abteilung f\u00fcr Infektionskrankheiten der Universit\u00e4t Heidelberg<\/a>. \u201eEs ist daher dringend notwendig, sowohl prophylaktische als auch therapeutische Strategien gegen dieses Virus zu entwickeln und umzusetzen.\u201c In einer neuen Studie f\u00fchrte Bartenschlager daher mit Unterst\u00fctzung des <a href=\"https:\/\/www.embl.de\/research\/units\/cbb\/schwab\/index.html\">Schwab-Teams<\/a> am Europ\u00e4ischen Laboratorium f\u00fcr Molekularbiologie in Heidelberg und unter Verwendung der <a href=\"https:\/\/www.embl.de\/services\/core_facilities\/em\/\">Elektronenmikroskopie-Anlage<\/a> des EMBL eine detaillierte bildgebende Analyse durch, um festzustellen, wie das Virus infizierte Zellen umprogrammiert.<\/p>\n\n\n\n<p>Zellen, die durch das Virus infiziert werden, sterben innerhalb von nur 24 bis 48 Stunden ab. Dies deutet darauf hin, dass das Virus die menschliche Zelle in einer Weise sch\u00e4digt, dass diese umprogrammiert und gezwungen wird, Virenpartikel zu produzieren. Die Identifizierung dieser morphologischen Ver\u00e4nderungen innerhalb einer Zelle war daher das Hauptziel des Projekts. \u201eUm Medikamente zu entwickeln, welche die virale Replikation unterdr\u00fccken und damit auch die Folgen der Infektion und des virusinduzierten Zelltods, ist es entscheidend, die biologischen Mechanismen, die den Replikationszyklus des Virus antreiben, besser zu verstehen,\u201c erkl\u00e4rt Bartenschlager. Deshalb nutzte das Team die bildgebenden Einrichtungen des EMBL und modernste bildgebende Verfahren, um die 3D-Architektur von SARS-CoV-2 sowie die virusbedingten Ver\u00e4nderungen der infizierten Zellen zu bestimmen.<\/p>\n\n\n\n<p>Das Team war in der Lage, 3D-Rekonstruktionen von ganzen Zellen und den subzellul\u00e4ren Kompartimenten zu erstellen. \u201eWir liefern kritische Einblicke in virusinduzierte Strukturver\u00e4nderungen in den untersuchten menschlichen Zellen,\u201c erkl\u00e4rt Bartenschlager. Die Bilder zeigten eine offensichtliche und massive Ver\u00e4nderung in den Endomembransystemen der infizierten Zellen \u2013 ein System, das der Zelle dazu dient, verschiedene Abteilungen und Orte zu definieren. Das Virus ver\u00e4ndert Membranen auf eine Art und Weise, dass es seine eigenen Replikationsorganellen produzieren kann. Dies sind Mini-Replikationsgef\u00e4\u00dfe, in denen das virale Genom enorm vervielf\u00e4ltigt wird. Dazu ben\u00f6tigt das Virus die Oberfl\u00e4che von Membranen, und das Virus holt sich diese Membranen von den Zellen. Es baut sie so um, dass eine Organelle entsteht, die ein sehr charakteristisches Aussehen hat. Die Wissenschaftler beschreiben es als eine massive Ansammlung von Blasen: zwei Membranschichten, die einen gro\u00dfen Ballon bilden. Innerhalb dieser Ballons \u2013 die ein sehr abgeschirmtes Beh\u00e4ltnis bilden \u2013 werden die viralen Genome repliziert und vermehrt.<\/p>\n\n\n\n<p>Diese auff\u00e4lligen Ver\u00e4nderungen zeigen sich bereits wenige Stunden nach der Infektion in den infizierten Zellen. \u201eWir sehen, wie und wo sich das Virus innerhalb der Zelle vermehrt und wie es seine Wirtszellen manipuliert, um nach der Vermehrung freigesetzt zu werden,\u201c sagte Yannick Schwab. \u00dcber die Entstehung und Entwicklung der Auswirkungen, die das Coronavirus im menschlichen K\u00f6rper hervorruft, war bisher wenig bekannt. Dazu geh\u00f6ren fehlende Kenntnisse \u00fcber den Mechanismus, wie die Infektion zum Absterben der infizierten Zellen f\u00fchrt. Mit den jetzt vorhandenen Informationen kann die Entwicklung von Therapien, die die Schwere der Krankheit verringern, beschleunigt werden.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"600\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1.jpg\" alt=\"\" class=\"wp-image-33782\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1.jpg 1000w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1-300x180.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/TEM-com-1000x600-1-768x461.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/a><figcaption class=\"vf-figure__caption\">Ein Teil einer infizierten Zelle wird mittels Transmissionselektronenmikroskopie beobachtet, wobei SARS-CoV-2-spezifische Strukturen (in rot, aus dem Spiegelbild rechts) bereits sechs Stunden nach der Infektion nachgewiesen werden k\u00f6nnen. Das Genom des Virus repliziert sich in hoher Kopienzahl in zwei Membranschichten zu einem gro\u00dfen Ballon (gro\u00dfe Strukturen in rot), der ein sehr abgeschirmtes Kompartiment bildet. Neue Virionen (kleine Strukturen in rot) werden durch Knospung an der Grenzfl\u00e4che zwischen dem endoplasmatischen Retikulum und dem Golgi-Apparat gebildet. Bildnachweis: Yannick Schwab\/EMBL<\/figcaption><\/figure>\n\n\n\n<p>Das Team sorgte daf\u00fcr, dass die gesammelten Informationen und insbesondere die beispiellose Sammlung von 3D-Strukturinformationen von virusinduzierten Substrukturen von jedermann genutzt werden k\u00f6nnen. \u201eIch glaube, dass wir damit einen Pr\u00e4zedenzfall daf\u00fcr schaffen, dass wir alle Daten, die wir produziert haben, mit der wissenschaftlichen Gemeinschaft teilen. Sie stellen eine beeindruckende Ressource f\u00fcr Wissenschaftler dar,\u201c betont Yannick Schwab. &#8220;Auf diese Weise k\u00f6nnen wir die weltweiten Bem\u00fchungen unterst\u00fctzen, zu untersuchen, wie SARS-CoV-2 mit seinem Wirt interagiert. Das Team hofft, dass die gesammelten Informationen zur Entwicklung antiviraler Medikamente beitragen werden.<\/p>\n\n\n\n<p>Dem Team ist es trotz der schwierigen Umst\u00e4nde gelungen, die Studie in unglaublich kurzer Zeit zu erstellen. \u201eDie halbe Welt \u2013 und nat\u00fcrlich auch Heidelberg \u2013 war im Lockdown, und wir mussten fast t\u00e4glich improvisieren, um uns an die Situation anzupassen. Ob am EMBL oder von zu Hause aus, alle waren extrem motiviert und haben gro\u00dfz\u00fcgig ihre Zeit und ihr Expertenwissen zur Verf\u00fcgung gestellt,\u201c betont Schwab stolz. \u201eDie Geschwindigkeit, mit der wir arbeiteten, und die Menge an Daten, die produziert wurde, ist bemerkenswert.\u201c<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers have studied SARS-CoV-2 replication in cells and obtained detailed insights into the alterations induced in infected cells. This information is essential to guide the development of urgently needed therapeutic strategies for suppressing viral replication and induced pathology.<\/p>\n","protected":false},"author":71,"featured_media":33778,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[227,1025,1331,136,1329,410],"embl_taxonomy":[2278,19375],"class_list":["post-33768","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-core-facility","tag-coronavirus","tag-covid-19","tag-electron-microscopy","tag-sars-cov-2","tag-schwab","embl_taxonomy-covid-19","embl_taxonomy-schwab-team"],"acf":{"featured":true,"show_featured_image":false,"color":"#007B53","link_color":"#fff","article_intro":"<p>Learning how SARS-CoV-2 hijacks host cell machineries will help in developing therapeutic strategies<\/p>\n","related_links":[{"link_description":"Schwab team","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/schwab\/index.html"},{"link_description":"AG Bartenschlager","link_url":"https:\/\/www.klinikum.uni-heidelberg.de\/zentrum-fuer-infektiologie\/molecular-virology\/about-us\/research-teams\/ag-bartenschlager"},{"link_description":"Department of Infectious Diseases, Molecular Virology at the Heidelberg University","link_url":"https:\/\/www.klinikum.uni-heidelberg.de\/zentrum-fuer-infektiologie\/molecular-virology\/"},{"link_description":"Electron Microscopy Core Facility at EMBL","link_url":"https:\/\/www.embl.de\/services\/core_facilities\/em\/"},{"link_description":"EMBL\u2019s contribution to fighting the coronavirus pandemic","link_url":"https:\/\/www.embl.org\/topics\/coronavirus\/"}],"article_sources":[{"source_description":"<p>Mirko Cortese <em>et al.<\/em> Integrative imaging reveals SARS-CoV-1 2 induced reshaping of subcellular morphologies. <em>Cell Host &amp; Microbe<\/em>, published online on 17 November 2020<br \/>\nDOI: https:\/\/doi.org\/10.1016\/j.chom.2020.11.003<\/p>\n","source_link_url":"https:\/\/doi.org\/10.1016\/j.chom.2020.11.003"}],"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"EMBL Generic","translations":[{"translation_language":"Deutsch","translation_anchor":"#german"}],"embl_taxonomy_term_who":false,"embl_taxonomy_term_what":false,"embl_taxonomy_term_where":false,"vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"a5d0c484-f12a-4a27-93cc-85e3a6d79c09\";i:2;s:36:\"5683518e-43cd-4740-8583-31a65ef324d3\";}","parents":[],"name":["COVID-19"],"slug":"covid-19","description":"What &gt; Topics &gt; COVID-19"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"64999cc4-9a7c-4fea-8339-0e2acc990e08\";i:2;s:36:\"2dcf8b52-afa2-431f-84be-1bb3efe757e5\";}","parents":[],"name":["Schwab Team"],"slug":"schwab-team","description":"What &gt; Cell biology and biophysics &gt; Schwab Team"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Replication cycle of SARS-CoV-2 in 3D | EMBL<\/title>\n<meta name=\"description\" content=\"Learning how SARS-CoV-2 hijacks host cell machineries will help in developing therapeutic strategies\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/covid-replication\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Replication cycle of SARS-CoV-2 in 3D | EMBL\" \/>\n<meta property=\"og:description\" content=\"Learning how SARS-CoV-2 hijacks host cell machineries will help in developing therapeutic strategies\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/covid-replication\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-23T09:00:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-15T10:44:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/cover-1000x600-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mathias J\u00e4ger\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mathias J\u00e4ger\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/covid-replication\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/covid-replication\/\"},\"author\":{\"name\":\"Mathias J\u00e4ger\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/63a0ca26daa6707834de41dfddfc6a42\"},\"headline\":\"Replication cycle of SARS-CoV-2 in 3D\",\"datePublished\":\"2020-11-23T09:00:16+00:00\",\"dateModified\":\"2025-07-15T10:44:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/covid-replication\/\"},\"wordCount\":1610,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/covid-replication\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/11\/cover-1000x600-1.jpg\",\"keywords\":[\"core facility\",\"coronavirus\",\"covid-19\",\"electron microscopy\",\"sars-cov-2\",\"schwab\"],\"articleSection\":[\"Science\",\"Science &amp; 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