{"id":3341,"date":"2015-02-04T13:57:45","date_gmt":"2015-02-04T12:57:45","guid":{"rendered":"http:\/\/news.embl.de\/?p=3341"},"modified":"2024-11-29T16:54:54","modified_gmt":"2024-11-29T15:54:54","slug":"1502_beyond_genetic_sequencing","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/","title":{"rendered":"Beyond sequencing"},"content":{"rendered":"\n<p>A new microscopy-based approach takes scientists a step beyond gene sequencing studies, enabling them to pinpoint which rare genetic variants \u2013 chunks of DNA which have a slightly different sequence in a few people \u2013 cause a disease. The method also allows researchers to draw meaningful conclusions already at smaller sample sizes, which is especially important in the context of diseases where it is difficult to simply find enough patients to run a sufficiently powerful study.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>it can be very difficult to make a diagnosis based on DNA sequence alone<\/p><\/blockquote>\n\n\n\n<p>\u201cI\u2019ve been working in diagnosing genetic diseases for many years, and very often we use sequencing. However, without a biochemical test or very clear clinical conviction it can be very difficult to make a diagnosis based on DNA sequence alone,\u201d says Heiko Runz. A human geneticist, Runz teamed up with <a title=\"Pepperkok lab|EMBL\" href=\"http:\/\/www.embl.de\/research\/units\/cbb\/pepperkok\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Rainer Pepperkok<\/a> from EMBL Heidelberg in the <a title=\"Molecular Medicine Partnership Unit|EMBL\" href=\"http:\/\/www.embl.de\/mmpu\/mmpu\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Molecular Medicine Partnership Unit<\/a> of EMBL and Heidelberg University Clinic, to tackle the issue.<\/p>\n\n\n\n<p>Together with researchers at the Broad Institute of MIT and Harvard, the team analysed data from 3000 people in Italy, half of which had suffered heart attacks before the age of 45. Heart attacks at such a young age are very rare, so it is likely that many of these patients have rare disorders that predispose them to heart disease. The scientists focused on one gene in particular: LDLR. Previous studies had linked multiple different changes in this gene to familial hypercholesterolemia \u2013 a rare, inherited disorder that can lead to high levels of cholesterol in the blood. But there was no easy way to tell which of those many changes, or variants, really caused the condition.<\/p>\n\n\n\n<blockquote class=\"vf-blockquote\"><p>This approach allows us to narrow down genetic results from mere associations to verifiable cause-and-effect<\/p><\/blockquote>\n\n\n\n<p>Scientists knew that cells whose LDLR doesn\u2019t work properly take up less cholesterol, leaving more cholesterol in a person\u2019s blood vessels, and thereby increasing the risk of atherosclerosis and heart attacks. Pepperkok \u2013 who alongside running his own lab also leads EMBL\u2019s <a title=\"Advanced Light Microscopy Facility|EMBL\" href=\"http:\/\/www.embl.de\/services\/core_facilities\/almf\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Advanced Light Microscopy Facility<\/a> and is <a title=\"Core Facilities|EMBL\" href=\"http:\/\/www.embl.de\/services\/core_facilities\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">Head of Core Facilities<\/a> \u2013 helped to engineer cells to carry the different versions of LDLR that had been observed in the Italian patients. He and and his team then developed an automated microscopy analysis to see which of those cells slowed their cholesterol uptake. The upshot: only 14 of the 70 variants found through sequencing had a visible impact on cells\u2019 ability to take up cholesterol.<\/p>\n\n\n\n<div class=\"wp-block-image size-full wp-image-3342\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-centered \"><a href=\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/attachment\/1502_beyond_sequencing_2\/\"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"204\" class=\"vf-figure__image\" src=\"http:\/\/news.embl.de\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_2.jpg\" alt=\"Normal cell (left) and cells with 2 variants of the same gene that cause different effects (middle, right). IMAGE FROM THORMAEHLEN ET AL.   \" class=\"wp-image-3342\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_2.jpg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_2-300x99.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><\/a><figcaption class=\"vf-figure__caption\">Different variants of the same gene can have very different effects on cells&#8217; cholesterol uptake (middle, right). Shown on the left are normal cells. IMAGE FROM THORMAEHLEN ET AL.<\/figcaption><\/figure><\/div>\n\n\n\n<p>\u201cTo some extent, this study is a call for caution,\u201d says Pepperkok: \u201ceveryone is very excited about the power of new sequencing technologies, but there is a risk of over-stating the results, because you find so many variants that are just not relevant.\u201d<\/p>\n\n\n\n<p>Pepperkok and Runz hope the work will inspire other geneticists and cell biologists to join forces. The new method developed through their own collaboration is widely applicable. It could be used to help untangle the genetics of virtually any condition where scientists know of an effect on cells that can be observed and quantified under the microscope. \u201cThis approach could prove very important to complement and thus improve the interpretation of genetic studies,\u201d says Pepperkok, \u201cit allows us to narrow down genetic results from mere associations to verifiable cause-and-effect.\u201d<\/p>\n\n\n\n<p>Aside from the doors it opens to understand the links between genes and disease in general, the study could have direct implications for those Italian patients. On the one hand, for patients who carry LDLR variants that seem not to have a great impact on cholesterol uptake, it may be worth looking for other potential heart attack triggers. And for patients who have variants that do cause problems in cholesterol uptake, this is confirmation that their condition is hereditary \u2013 and could therefore impact their family. Runz points out that if patients know that their condition has a genetic root, this often increases the likelihood that they will follow their treatment regimes and motivates them for necessary lifestyle changes.<\/p>\n\n\n\n<p>\u201cWe are in direct contact with the physicians, who can decide if and how to best share the new information with patients,\u201d says Runz, who recently moved to Merck Research Labs in Boston, USA, \u201cand we\u2019re also discussing follow-up studies to further improve our understanding \u2013 and patient outcomes.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease.<\/p>\n","protected":false},"author":8,"featured_media":3343,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[64,41,32,43,49,69,79,25],"embl_taxonomy":[],"class_list":["post-3341","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-biology","tag-genetics","tag-health","tag-heidelberg","tag-interdisciplinary","tag-methods","tag-microscopy","tag-partnerships"],"acf":{"article_intro":"<p>Human geneticists and cell biologists in Heidelberg have gone\u00a0beyond vague links between genes and disease\u00a0to\u00a0pinpoint\u00a0cause and effect, in a study they see as both a poster-child for cross-discipline collaboration and a call for caution.<\/p>\n","related_links":false,"article_sources":[{"source_description":"<p>Thormaehlen <em>et al<\/em>., <em>PLoS Genetics<\/em>, 3 February 2015. DOI: 10.1371\/journal.pgen.1004855<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.1371\/journal.pgen.1004855"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Beyond sequencing | EMBL<\/title>\n<meta name=\"description\" content=\"New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Beyond sequencing | EMBL\" \/>\n<meta property=\"og:description\" content=\"New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-02-04T12:57:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-29T15:54:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"424\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sonia Furtado Neves\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Aur_ora\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sonia Furtado Neves\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\"},\"author\":{\"name\":\"Sonia Furtado Neves\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68\"},\"headline\":\"Beyond sequencing\",\"datePublished\":\"2015-02-04T12:57:45+00:00\",\"dateModified\":\"2024-11-29T15:54:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\"},\"wordCount\":733,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg\",\"keywords\":[\"cell biology\",\"genetics\",\"health\",\"heidelberg\",\"interdisciplinary\",\"methods\",\"microscopy\",\"partnerships\"],\"articleSection\":[\"Science\",\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\",\"name\":\"Beyond sequencing | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg\",\"datePublished\":\"2015-02-04T12:57:45+00:00\",\"dateModified\":\"2024-11-29T15:54:54+00:00\",\"description\":\"New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg\",\"width\":620,\"height\":424,\"caption\":\"The new method helps identify which mutations to a gene actually cause a disease. IMAGE FROM THORMAEHLEN ET AL.\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.embl.org\/news\/#website\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"name\":\"European Molecular Biology Laboratory News\",\"description\":\"News from the European Molecular Biology Laboratory\",\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"alternateName\":\"EMBL News\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.embl.org\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.embl.org\/news\/#organization\",\"name\":\"European Molecular Biology Laboratory\",\"alternateName\":\"EMBL\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"width\":300,\"height\":144,\"caption\":\"European Molecular Biology Laboratory\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/embl.org\/\",\"https:\/\/x.com\/embl\",\"https:\/\/www.instagram.com\/embl_org\/\",\"https:\/\/www.linkedin.com\/company\/15813\/\",\"https:\/\/www.youtube.com\/user\/emblmedia\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68\",\"name\":\"Sonia Furtado Neves\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g\",\"caption\":\"Sonia Furtado Neves\"},\"description\":\"Sonia Furtado Neves is EMBL's Core Content Manager and Press Officer. The world never ceases to stun her, and she loves sharing that awe, wonder and amazement.\",\"sameAs\":[\"https:\/\/x.com\/Aur_ora\"],\"url\":\"https:\/\/www.embl.org\/news\/author\/sonia\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Beyond sequencing | EMBL","description":"New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/","og_locale":"en_US","og_type":"article","og_title":"Beyond sequencing | EMBL","og_description":"New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease","og_url":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/","og_site_name":"EMBL","article_publisher":"https:\/\/www.facebook.com\/embl.org\/","article_published_time":"2015-02-04T12:57:45+00:00","article_modified_time":"2024-11-29T15:54:54+00:00","og_image":[{"width":620,"height":424,"url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","type":"image\/jpeg"}],"author":"Sonia Furtado Neves","twitter_card":"summary_large_image","twitter_creator":"@Aur_ora","twitter_site":"@embl","twitter_misc":{"Written by":"Sonia Furtado Neves","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#article","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/"},"author":{"name":"Sonia Furtado Neves","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68"},"headline":"Beyond sequencing","datePublished":"2015-02-04T12:57:45+00:00","dateModified":"2024-11-29T15:54:54+00:00","mainEntityOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/"},"wordCount":733,"publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","keywords":["cell biology","genetics","health","heidelberg","interdisciplinary","methods","microscopy","partnerships"],"articleSection":["Science","Science &amp; Technology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/","url":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/","name":"Beyond sequencing | EMBL","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","datePublished":"2015-02-04T12:57:45+00:00","dateModified":"2024-11-29T15:54:54+00:00","description":"New microscopy-based method goes beyond gene sequencing, pinpointing the cause of disease","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/science\/1502_beyond_genetic_sequencing\/#primaryimage","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","width":620,"height":424,"caption":"The new method helps identify which mutations to a gene actually cause a disease. IMAGE FROM THORMAEHLEN ET AL."},{"@type":"WebSite","@id":"https:\/\/www.embl.org\/news\/#website","url":"https:\/\/www.embl.org\/news\/","name":"European Molecular Biology Laboratory News","description":"News from the European Molecular Biology Laboratory","publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"alternateName":"EMBL News","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.embl.org\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.embl.org\/news\/#organization","name":"European Molecular Biology Laboratory","alternateName":"EMBL","url":"https:\/\/www.embl.org\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","width":300,"height":144,"caption":"European Molecular Biology Laboratory"},"image":{"@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/embl.org\/","https:\/\/x.com\/embl","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/15813\/","https:\/\/www.youtube.com\/user\/emblmedia\/"]},{"@type":"Person","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68","name":"Sonia Furtado Neves","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/85ae4046e9b9b00d1fbd909d6541dc5522ea35db24faaf4b2a5ebcc56dd4846f?s=96&d=mm&r=g","caption":"Sonia Furtado Neves"},"description":"Sonia Furtado Neves is EMBL's Core Content Manager and Press Officer. The world never ceases to stun her, and she loves sharing that awe, wonder and amazement.","sameAs":["https:\/\/x.com\/Aur_ora"],"url":"https:\/\/www.embl.org\/news\/author\/sonia\/"}]}},"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"fimg_url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","featured_image_src":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/02\/1502_beyond_sequencing_1-e1423053815788.jpg","_links":{"self":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/3341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/comments?post=3341"}],"version-history":[{"count":8,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/3341\/revisions"}],"predecessor-version":[{"id":20873,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/3341\/revisions\/20873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media\/3343"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media?parent=3341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/categories?post=3341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/tags?post=3341"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/embl_taxonomy?post=3341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}