{"id":3309,"date":"2015-01-28T13:26:09","date_gmt":"2015-01-28T12:26:09","guid":{"rendered":"http:\/\/news.embl.de\/?p=3309"},"modified":"2024-11-29T16:55:05","modified_gmt":"2024-11-29T15:55:05","slug":"1501_barcoding-epigenetics","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/","title":{"rendered":"Barcoding epigenetics"},"content":{"rendered":"\n<p>The approach, called Bar-ChIP, is based on attaching molecular barcodes to the fragments of genetic material the researchers want to study, and enables scientists to process many samples in parallel, without having to resort to robotic devices.<\/p>\n\n\n\n<p>\u201cWith Bar-ChIP, we were able to probe fifteen individual chromatin extract samples at once for an epigenetic mark,\u201d says PhD student Christophe Chabbert, who carried out the research together with postdoc Sophie Adjalley. \u201cThis means that instead of performing 75 independent experiments, only five experiments were required to get the same information.\u201d<\/p>\n\n\n\n<p>Applying their new technique to yeast, the EMBL scientists have begun to untangle how having one specific tag may affect whether a histone \u2013 one of the proteins DNA is coiled around \u2013 receives further tags.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New Bar-ChIP method makes it easier to search for epigenetic marks in many samples at once<\/p>\n","protected":false},"author":8,"featured_media":3313,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[40,43,69],"embl_taxonomy":[],"class_list":["post-3309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-gene-regulation","tag-heidelberg","tag-methods"],"acf":{"article_intro":"<p>Searching for epigenetic marks \u2013 chemical tags that influence how a cell\u2019s genetic information is read \u2013 in many samples at once has just become easier, thanks to a new method developed by the <a title=\"Steinmetz lab|EMBL\" href=\"http:\/\/www.embl.de\/research\/units\/genome_biology\/steinmetz\" target=\"_blank\">Steinmetz lab <\/a>at EMBL Heidelberg.<\/p>\n","related_links":[{"link_description":"The Steinmetz lab","link_url":"http:\/\/www.embl.de\/research\/units\/genome_biology\/steinmetz"}],"article_sources":[{"source_description":"<p>Chabbert, Adjalley <em>et al<\/em>., <em>Molecular Systems <\/em>Biology, 12 January 2015. DOI 10.15252\/msb.20145776<\/p>\n","source_link_url":"http:\/\/dx.doi.org\/10.15252\/msb.20145776"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Barcoding epigenetics | EMBL<\/title>\n<meta name=\"description\" content=\"New Bar-ChIP method makes it easier to search for epigenetic marks in many samples at once\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Barcoding epigenetics | EMBL\" \/>\n<meta property=\"og:description\" content=\"New Bar-ChIP method makes it easier to search for epigenetic marks in many samples at once\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2015-01-28T12:26:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-29T15:55:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/01\/1501_barcoding_epigenetics_11.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"465\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Sonia Furtado Neves\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@Aur_ora\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Sonia Furtado Neves\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\"},\"author\":{\"name\":\"Sonia Furtado Neves\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/d926199a955624b44dda296f396c5e68\"},\"headline\":\"Barcoding epigenetics\",\"datePublished\":\"2015-01-28T12:26:09+00:00\",\"dateModified\":\"2024-11-29T15:55:05+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\"},\"wordCount\":124,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/01\/1501_barcoding_epigenetics_11.jpg\",\"keywords\":[\"gene regulation\",\"heidelberg\",\"methods\"],\"articleSection\":[\"Science\",\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\",\"name\":\"Barcoding epigenetics | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/01\/1501_barcoding_epigenetics_11.jpg\",\"datePublished\":\"2015-01-28T12:26:09+00:00\",\"dateModified\":\"2024-11-29T15:55:05+00:00\",\"description\":\"New Bar-ChIP method makes it easier to search for epigenetic marks in many samples at once\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/1501_barcoding-epigenetics\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/01\/1501_barcoding_epigenetics_11.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2015\/01\/1501_barcoding_epigenetics_11.jpg\",\"width\":620,\"height\":465,\"caption\":\"Barcoding enables scientists to search for epigenetics tags in many samples at once. 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