{"id":31946,"date":"2020-09-03T12:00:00","date_gmt":"2020-09-03T10:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=31946"},"modified":"2024-03-22T11:15:12","modified_gmt":"2024-03-22T10:15:12","slug":"erc-grants-2020","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/erc-grants-2020\/","title":{"rendered":"EMBL scientists receive prestigious ERC Starting Grants"},"content":{"rendered":"\n<p>Maria Bernabeu\u2019s group at EMBL Barcelona studies cerebral malaria \u2013 but in a very unique way. This neurovascular complication of the parasitic disease accounts for more than 400,000 deaths each year in Sub-Saharan Africa, most of them in children under the age of five. The origins of this complication are still unknown, mainly because of the impossibility of accessing a patient\u2019s brain at the time of the infection and the lack of good animal models.&nbsp;<\/p>\n\n\n\n<p>Bernabeu joined EMBL Barcelona as a group leader in October 2019. Her <a href=\"https:\/\/www.embl.es\/research\/unit\/bernabeu\/index.html\">research group<\/a> recreates living human blood vessels in the lab, through which she can flow human red blood cells \u2013 both healthy ones and those infected with malaria. In her project Mal3D-BBB, for which she was awarded the European Research Council (ERC) grant, she plans to use this technology to create a 3D replica of the brain microvessels \u2013 known as the blood\u2013brain barrier (BBB) \u2013 to understand how malaria parasites cause damage in the brain. By recreating this complex human pathology \u2018in a dish\u2019, Bernabeu\u2019s group will then be able to add immune system cells, immune signalling molecules called cytokines, and coagulation factors thought to contribute to brain damage, to analyse the changes at the molecular, cellular, and tissue levels.&nbsp;<\/p>\n\n\n\n<p>\u201cIf we can understand the pathogenic mechanisms of cerebral malaria, we will have clues to develop, or reuse, drugs that improve disease outcome and reduce patient mortality,\u201d explains Bernabeu.&nbsp;<\/p>\n\n\n\n<p>At EMBL Grenoble, Wojciech Galej studies large RNA\u2013protein complexes involved in gene expression. He joined EMBL as a group leader in 2016. His ERC-funded project will focus on a process known as pre-mRNA splicing. During this process, the precursors of instruction-carrying molecules called messenger RNAs are edited to remove those segments \u2013 known as introns \u2013 that do not contain the information needed to make proteins. Splicing is catalysed by an extremely large RNA\u2013protein complex \u2013 the spliceosome.<\/p>\n\n\n\n<p>In humans, the majority of introns are cut out by the major type of spliceosome. Some introns, however, must be excised by specialised machinery. This \u2018minor spliceosome\u2019 is what Galej and his group study. Introns that depend on the minor spliceosome are relatively rare, but are located in genes with critical cellular functions. Several genetic disorders are associated with malfunctions of the minor spliceosome.<\/p>\n\n\n\n<p>\u201cOur goal is to obtain functional and structural insights into this process, which were largely missing until now,\u201d explains Galej. \u201cIn the long term, mechanistic understanding of the process involving the minor spliceosome may have an impact on human health.\u201d<\/p>\n\n\n\n<p>With this award, Bernabeu and Galej join other EMBL scientists holding an <a href=\"https:\/\/www.embl.de\/research\/faculty\/erc-investigators\/index.html\">ERC Grant<\/a>.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>A bigger and interdisciplinary group<\/strong><\/h3>\n\n\n\n<p>The European Research Council is Europe\u2019s main research funding organisation, and their Starting Grants award young group leaders across Europe \u20ac1.5 million over five years to carry out research projects.&nbsp;<\/p>\n\n\n\n<p>Bernabeu\u2019s plan is to recruit an interdisciplinary group of biologists, engineers, and biophysicists to develop her project. This will include engaging in collaborative work with other research groups at EMBL, as well as the <a href=\"https:\/\/www.embl.es\/services\/mesoscopic-imaging-facility\/index.html\">Mesoscopic Imaging Facility<\/a> at EMBL Barcelona, and the <a href=\"https:\/\/www.embl.de\/services\/core_facilities\/em\/\">Electron Microscopy Core Facility<\/a> at EMBL Heidelberg. Key to this project will be collaborations with scientists at the London School of Hygiene and Tropical Medicine, and clinicians at Ispat General Hospital in Rourkela, India. \u201cOur aim is to bring together expertise from different scientific fields to develop the 3D BBB model, which will not only have future applications in malaria, but also in other diseases that affect the brain vasculature, such as Alzheimer\u2019s or COVID-19.\u201d<\/p>\n\n\n\n<p>Galej\u2019s group already has talented researchers working on his project, but the grant will enable him to make additional hires. \u201cThanks to the ERC grant, I will be able to recruit a PhD student and two more postdocs in order to expand our current expertise and explore new research directions,\u201d he says. Another crucial aspect for him is to strengthen existing collaborations within EMBL. \u201cWe\u2019re very lucky to have access to excellent services offered by the EMBL core facilities, in particular the Proteomics Core Facility and the Cryo-EM Service Platform. With new collaborations, we\u2019re also planning to expand our research towards more functional, <em>in vivo<\/em> studies and transcriptome-wide analysis of splicing patterns.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Maria Bernabeu and Wojciech Galej have each been awarded \u20ac1.5 million to research malaria and pre-mRNA splicing, respectively.<\/p>\n","protected":false},"author":94,"featured_media":31950,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17597,3],"tags":[149,497,543,485,37,330,752,3628],"embl_taxonomy":[19173,9792,19261],"class_list":["post-31946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-embl-announcements","category-lab-matters","tag-award","tag-barcelona","tag-erc-grant","tag-galej","tag-grenoble","tag-malaria","tag-mrna","tag-splicing","embl_taxonomy-bernabeu-group","embl_taxonomy-embl-grenoble","embl_taxonomy-galej-group"],"acf":{"featured":true,"show_featured_image":false,"color":"#54585a","link_color":"#fff","article_intro":"<p>Maria Bernabeu and Wojciech Galej have each been awarded \u20ac1.5 million to research malaria and pre-mRNA splicing, respectively<\/p>\n","related_links":[{"link_description":"","link_url":""},{"link_description":"","link_url":""},{"link_description":"","link_url":""},{"link_description":"","link_url":""}],"article_sources":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"None","vf_locked":false,"field_target_display":"","source_article":false,"field_article_language":{"value":"english","label":"English"},"article_translations":false,"languages":""},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"18a7a17b-e276-4afd-b0ca-8ddac1883d45\";i:2;s:36:\"71aeb1fd-6b3c-4f66-bae8-a09e9fbedf58\";}","parents":[],"name":["Bernabeu Group"],"slug":"bernabeu-group","description":"What &gt; Tissue biology and disease modelling &gt; Bernabeu Group"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"8f81131e-d37c-470c-848f-618fce652295\";}","parents":[],"name":["EMBL Grenoble"],"slug":"embl-grenoble","description":"Where &gt; All EMBL sites &gt; EMBL Grenoble"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"fc528877-4017-438f-85b4-de2b54c443f1\";i:2;s:36:\"b3d9805e-9765-4a93-a6bb-56dfdc7142ff\";}","parents":[],"name":["Galej Group"],"slug":"galej-group","description":"What &gt; Structural Biology (EMBL Grenoble) &gt; Galej Group"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - 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