{"id":31860,"date":"2020-09-02T13:56:18","date_gmt":"2020-09-02T11:56:18","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=31860"},"modified":"2024-03-22T11:15:17","modified_gmt":"2024-03-22T10:15:17","slug":"organoid-cell-atlas","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/lab-matters\/organoid-cell-atlas\/","title":{"rendered":"An organoid cell atlas to enhance biomedical research"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">An organoid data resource<\/h3>\n\n\n\n<p>To address some of these questions, researchers are planning to create a specialised Organoid Cell Atlas, which will foster the production, quality control, dissemination, and utilisation of single-cell data for human organoids. By creating well-characterised in vitro models of human organs, this resource could enable translational research on rare genetic diseases, complex multifactorial diseases, and cancer.<\/p>\n\n\n\n<p>The HCA|Organoid project is one of six pilot actions funded by the EU Horizon 2020 Framework Programme, which will be European contributions to the Human Cell Atlas (HCA) project. HCA is an ambitious global initiative striving to advance biomedical research and therapy using single-cell technologies. The HCA|Organoid consortium comprises eight partners, including EMBL\u2019s European Bioinformatics Institute, and will receive \u20ac5 million in EU funding.<br \/><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Potential applications<\/h3>\n\n\n\n<p>Organoids can serve as models of human physiology and pathology, so they can be used in interventional studies that are difficult or impossible to conduct on humans. This also reduces the need for animal experiments.<\/p>\n\n\n\n<p>Organoids can also be used as patient \u2018avatars\u2019 for drug development and personalised medicine, for example in cancer therapy or for some genetic diseases, such as cystic fibrosis.<br \/>Finally, organoids also help advance regenerative medicine, with the ultimate goal of producing functional biological structures that can be transplanted into patients.<\/p>\n\n\n\n<p>Read the full vision for the&nbsp;<a href=\"https:\/\/zenodo.org\/record\/4001718#.X04AYJNKj64\">HCA Organoid project in the marker paper available as a preprint<\/a>.&nbsp;You can also&nbsp;<a href=\"https:\/\/www.hca-organoid.eu\/news\/kickstarting-organoid-cell-atlas\">read the original press release<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>EMBL-EBI is one of the eight European institutes involved in the Humanoid Cell Atlas initiative, a new open-access platform that combines single-cell profiling and organoid technology<\/p>\n","protected":false},"author":47,"featured_media":31902,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[17597,3],"tags":[28,502,966,491,504],"embl_taxonomy":[2906],"class_list":["post-31860","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-embl-announcements","category-lab-matters","tag-bioinformatics","tag-human-cell-atlas","tag-organoid","tag-single-cell-genomics","tag-single-cell-sequencing","embl_taxonomy-embl-ebi"],"acf":{"vf_locked":false,"featured":true,"show_featured_image":false,"color":"#007B53","link_color":"#fff","article_intro":"<p>Organoids are groups of cells grown in laboratories. The cellular structures in organoids are similar to those found in specific organs. Organoids can be useful tools for biomedical research, but because they are still relatively new, there are many unanswered questions about how they work.<\/p>\n","related_links":[{"link_description":"Funding to predict the risk of infectious disease outbreaks\r\n","link_url":"https:\/\/www.embl.org\/news\/lab-matters\/funding-to-predict-the-risk-of-infectious-disease-outbreaks\/"},{"link_description":"Visualising the cell\u2019s molecular machinery in action\r\n","link_url":"https:\/\/www.embl.org\/news\/science\/visualising-the-cells-molecular-machinery-in-action\/"}],"article_sources":[{"source_description":"<p>C. Bock., <em>et al.<\/em> The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy. Published online on 30 August 2020. DOI: 10.5281\/zenodo.4001718<\/p>\n","source_link_url":"https:\/\/zenodo.org\/record\/4001718#.X04AYJNKj64"}],"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"None","translations":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"a99d1a7c-ca83-4c00-ab61-d082d3e41ce3\";}","parents":[],"name":["EMBL-EBI"],"slug":"embl-ebi","description":"Where &gt; All EMBL sites &gt; EMBL-EBI"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>An organoid cell atlas to enhance biomedical research | EMBL<\/title>\n<meta name=\"description\" content=\"EMBL-EBI supports the Organoid Cell Atlas, a new open-access platform that combines single-cell profiling and organoid technology.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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