{"id":30496,"date":"2020-09-02T17:00:00","date_gmt":"2020-09-02T15:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=30496"},"modified":"2024-03-22T11:09:23","modified_gmt":"2024-03-22T10:09:23","slug":"remove-material-nucleus","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/remove-material-nucleus\/","title":{"rendered":"How to remove unwanted components from the cell nucleus"},"content":{"rendered":"\n

The organisation of cells into specific compartments is critical for their function. For instance, by separating the nucleus from the cytoplasm, the nuclear envelope prevents premature translation of immature RNAs.<\/p>\n\n\n\n

During mitosis, however, the nuclear envelope disassembles, allowing large cytoplasmic components such as ribosomes to mix with nuclear material. When the nuclear envelope reassembles following mitosis, these cytoplasmic components must once again be removed. \u201cThe nuclear envelope can contribute to this by actively importing or exporting substrates up to a certain size, but it was not clear what happens with very large cytoplasmic components\u201d, says Mina Petrovic, from the Gerlich lab at IMBA \u2013 the Institute of Molecular Biotechnology<\/a> \u2013 and joint first author of the study.<\/p>\n\n\n\n

The research team from IMBA and EMBL have now shown that large components such as ribosomes are in fact removed from the forming nucleus before the nuclear envelope is assembled again. This exclusion process requires the protein Ki-67, which was the focus of an earlier publication in Nature by Sara Cuylen-H\u00e4ring, group leader at EMBL Heidelberg<\/a> and the other joint first author of this study.<\/p>\n\n\n\n

In this older study it was discovered that Ki-67 was responsible for keeping chromosomes separated in early stages of mitosis by acting as a surfactant. \u201cRemarkably, we have now found that it changes its properties at the end of mitosis and performs the opposite function, namely clustering of chromosomes,\u201d said Cuylen-H\u00e4ring. By coming together into a dense cluster at the end of cell division, chromosomes are able to exclude large cytoplasmic components before the nuclear envelope reforms.<\/p>\n\n\n\n

\u201cThis collaborative work shows how a single protein can dynamically change the surface properties of chromosomes,\u201d explains Alberto Hernandez Armendariz, PhD student in the Cuylen-H\u00e4ring group. \u201cUltimately, this facilitates effective compartmentalisation of key processes within the cell.\u201d<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers have uncovered how cells remove unwanted components from the nucleus following mitosis.<\/p>\n","protected":false},"author":71,"featured_media":30504,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[535,4716,4686,616],"embl_taxonomy":[19111],"class_list":["post-30496","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-chromosome","tag-cuylen-haring","tag-nucleus","tag-protein","embl_taxonomy-sara-cuylen-haring"],"acf":{"featured":true,"color":"#007B53","show_featured_image":false,"article_intro":"

Scientists\u00a0 from EMBL Heidelberg and the Institute of Molecular Biotechnology have uncovered how cells remove unwanted components from the nucleus following mitosis.<\/p>\n","article_sources":[{"source_description":"

Sara Cuylen et al. Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. Nature, published 29 June 2016. DOI: 10.1038\/nature18610<\/p>\n","source_link_url":"https:\/\/www.nature.com\/articles\/nature18610"},{"source_description":"

Sara Cuylen-H\u00e4ring\u00a0 et al. Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly. Nature<\/em>, published on 02 September 2020. DOI: 10.1038\/s41586-020-2672-3<\/p>\n","source_link_url":"https:\/\/www.nature.com\/articles\/s41586-020-2672-3"}],"related_links":[{"link_description":"IMBA \u2013 Institute for Molecular Biotechnology","link_url":"https:\/\/www.imba.oeaw.ac.at\/"},{"link_description":"Cuylen-H\u00e4ring group","link_url":"https:\/\/www.embl.de\/research\/units\/cbb\/cuylen\/index.html"}],"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","link_color":"#fff","press_contact":"EMBL Generic","translations":false},"embl_taxonomy_terms":[{"uuid":"a:2:{i:0;s:36:\"4428d1fd-441a-4d6d-a1c5-5dcf5665f213\";i:1;s:36:\"ef3ac93a-528f-4037-a44f-c6f9de189325\";}","parents":[],"name":["Sara Cuylen-H\u00e4ring"],"slug":"sara-cuylen-haring","description":"Who > Sara Cuylen-H\u00e4ring"}],"yoast_head":"\nHow to remove unwanted components from the cell nucleus | EMBL<\/title>\n<meta name=\"description\" content=\"Researchers have shown that large components are removed from the forming nucleus 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