{"id":29022,"date":"2009-09-13T18:00:00","date_gmt":"2009-09-13T16:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=29022"},"modified":"2024-11-14T16:27:59","modified_gmt":"2024-11-14T15:27:59","slug":"how-stem-cells-make-skin","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/","title":{"rendered":"How stem cells make skin"},"content":{"rendered":"\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2009\/09\/stem-cells-skin-nerlov-group-2009.tif\"><img loading=\"lazy\" decoding=\"async\" width=\"945\" height=\"715\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009.jpg\" alt=\"In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C\/EBP\u03b1 nor C\/EBP\u03b2 (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C\/EBP\u03b1 is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell \u2018program\u2019 (yellow\/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.\" class=\"wp-image-29038\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009.jpg 945w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009-300x227.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009-768x581.jpg 768w\" sizes=\"auto, (max-width: 945px) 100vw, 945px\" \/><\/a><figcaption class=\"vf-figure__caption\">In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C\/EBP\u03b1 nor C\/EBP\u03b2 (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C\/EBP\u03b1 is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell \u2018program\u2019 (yellow\/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour. Click on image to download a high resolution version (tiff).<\/figcaption><\/figure>\n\n\n\n<p>Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above. Scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, in collaboration with colleagues at the <a href=\"http:\/\/www.ciemat.es\/\" target=\"_blank\" rel=\"noreferrer noopener\">Centro de Investigaciones Energ\u00e9ticas, Medioambientales y Tecnologicas (CIEMAT)<\/a> in Madrid, have discovered two proteins that control when and how these stem cells switch to being skin cells. The findings, published online today in <em>Nature Cell Biology<\/em>, shed light on the basic mechanisms involved not only in formation of skin, but also on skin cancer and other epithelial cancers.<\/p>\n\n\n\n<p>At some point in their lives, the stem cells at the base of the skin stop proliferating and start differentiating into the cells that form the skin itself. To do so, they must turn off the \u2018stem cell programme\u2019 in their genes and turn on the \u2018skin cell programme\u2019. Researchers suspected that a family of proteins called C\/EBPs might be involved in this process, as they were known to regulate it in other types of stem cell, but had so far failed to identify which C\/EBP protein controlled the switch in skin. Claus Nerlov and his group at EMBL Monterotondo discovered it was not one protein, but two: C\/EBP\u03b1 and C\/EBP\u03b2.<\/p>\n\n\n\n<p>The EMBL researchers used genetic engineering techniques to delete the genes that encode C\/EBP\u03b1 and \u03b2 specifically in the skin of mouse embryos, and found that without these proteins the skin of the mice did not form properly.<\/p>\n\n\n\n<p>\u201cMice with neither C\/EBP\u03b1 nor \u03b2 had taut and shiny skin that couldn\u2019t keep the water inside their bodies\u201d, Nerlov explains, \u201cthey lacked many of the proteins that make skin mechanically strong and water tight, and they died of de-hydration shortly after birth\u201d.<\/p>\n\n\n\n<p>However, a single working copy of either the gene for C\/EBP\u03b1 or the gene for C\/EBP\u03b2 was enough to ensure that skin developed properly. This means that the two proteins normally do the same job in the skin\u2019s stem cells &#8211; an unexpected redundancy, which may have arisen because there are so many stem cells in skin that a tight control on proliferation is needed to avoid problems like cancer. Or it may simply be a by-product of the fact that these two proteins have different functions in other situations, such as wound healing or repair of sunlight-induced skin damage.<\/p>\n\n\n\n<p>One of the hallmarks of epithelial cancers &#8211; which include skin, breast, and oral cancers &#8211; is that they have genes turned on which would normally only be expressed in embryonic stem cells, and which may help cancer cells divide indefinitely. Such genes become re-expressed in the skin in the absence of C\/EBPs. So, by understanding how C\/EBP\u03b1 and \u03b2 turn off such \u2018stem cell\u2019 programmes, researchers hope to come a step closer to finding ways to fight such cancers.<\/p>\n\n\n\n<p>When Nerlov and colleagues looked at how C\/EBP\u03b1 and -\u03b2 work in the skin, they found that these proteins also regulate a number of other molecules that control skin development. Several important pathways known to control skin and hair formation were improperly activated in the mice lacking C\/EBP\u03b1 and -\u03b2.<\/p>\n\n\n\n<p>\u201cThis is a very important discovery\u201d, says Nerlov. \u201cIt opens up a lot of new areas, because we can see how these proteins control virtually every other molecule known to regulate skin cell differentiation. It seems to be a key piece in the puzzle of how our skin is formed and maintained throughout life.\u201d&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.&hellip;<\/p>\n","protected":false},"author":16,"featured_media":29038,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[38,954,4264,3942,1748,611,118],"embl_taxonomy":[9788,5144],"class_list":["post-29022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cancer","tag-mouse","tag-nerlov","tag-picture-release","tag-press-release","tag-skin","tag-stem-cell","embl_taxonomy-embl-rome","embl_taxonomy-epigenetics-and-neurobiology"],"acf":{"vf_locked":false,"featured":true,"color":"#007B53","show_featured_image":true,"article_intro":"<h2>EMBL scientists come a step closer to understanding skin, breast and other cancers<\/h2>\n","article_sources":[{"source_description":"<p>Lopez, R. G., Garcia-Silva, S., Moore, S. J., Bereshchenko, O., Martinez-Cruz, A. B., Ermakova, O., Kurz, E., Paramio, J. M. &#038; Nerlov, C. C\/EBP\u03b1 and -\u03b2 couple interfollicular keratinocyte proliferation arrest to commitment and terminal differentiation. <em>Nature Cell Biology<\/em>, Avanced Online Publication, 13 September 2009 . DOI: 10.1038\/ncb1960 <\/p>\n","source_link_url":"https:\/\/www.nature.com\/articles\/ncb1960"}],"related_links":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"EMBL Generic","translations":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"741d5d3d-f92f-4eb8-9195-55c96454a36b\";}","parents":[],"name":["EMBL Rome"],"slug":"embl-rome","description":"Where &gt; All EMBL sites &gt; EMBL Rome"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"7ca3ce91-dc32-47ea-8d4b-7a53c3a3a9fd\";i:2;s:36:\"a6e35bb0-c32d-4c9b-aadb-a19b6c7b060f\";}","parents":[],"name":["Epigenetics and neurobiology"],"slug":"epigenetics-and-neurobiology","description":"What &gt; Research Units &gt; Epigenetics and neurobiology"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How stem cells make skin | EMBL<\/title>\n<meta name=\"description\" content=\"Scientists at the European Molecular Biology Laboratory (EMBL) come a step closer to understanding skin, breast and other cancers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How stem cells make skin | EMBL\" \/>\n<meta property=\"og:description\" content=\"Scientists at the European Molecular Biology Laboratory (EMBL) come a step closer to understanding skin, breast and other cancers.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2009-09-13T16:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-14T15:27:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"945\" \/>\n\t<meta property=\"og:image:height\" content=\"715\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Guest author(s)\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Guest author(s)\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/\"},\"author\":{\"name\":\"Guest author(s)\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b\"},\"headline\":\"How stem cells make skin\",\"datePublished\":\"2009-09-13T16:00:00+00:00\",\"dateModified\":\"2024-11-14T15:27:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/\"},\"wordCount\":762,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/how-stem-cells-make-skin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009.jpg\",\"keywords\":[\"cancer\",\"mouse\",\"nerlov\",\"picture release\",\"press release\",\"skin\",\"stem cell\"],\"articleSection\":[\"Science\",\"Science &amp; 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In mice whose skin has neither C\/EBP\u03b1 nor C\/EBP\u03b2 (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C\/EBP\u03b1 is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell \u2018program\u2019 (yellow\/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour."},{"@type":"WebSite","@id":"https:\/\/www.embl.org\/news\/#website","url":"https:\/\/www.embl.org\/news\/","name":"European Molecular Biology Laboratory News","description":"News from the European Molecular Biology Laboratory","publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"alternateName":"EMBL News","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.embl.org\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.embl.org\/news\/#organization","name":"European Molecular Biology Laboratory","alternateName":"EMBL","url":"https:\/\/www.embl.org\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","width":300,"height":144,"caption":"European Molecular Biology Laboratory"},"image":{"@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/embl.org\/","https:\/\/x.com\/embl","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/15813\/","https:\/\/www.youtube.com\/user\/emblmedia\/"]},{"@type":"Person","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b","name":"Guest author(s)","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/300b9a1d66050ae03eaeb99869c6ebb30f5184b9468e92a2b3e7d28bc9cf742d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/300b9a1d66050ae03eaeb99869c6ebb30f5184b9468e92a2b3e7d28bc9cf742d?s=96&d=mm&r=g","caption":"Guest author(s)"},"description":"Guest author(s)","url":"https:\/\/www.embl.org\/news\/author\/guest-author\/"}]}},"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"fimg_url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009.jpg","featured_image_src":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/stem-cells-skin-nerlov-group-2009.jpg","_links":{"self":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/29022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/comments?post=29022"}],"version-history":[{"count":11,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/29022\/revisions"}],"predecessor-version":[{"id":29050,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/29022\/revisions\/29050"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media\/29038"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media?parent=29022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/categories?post=29022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/tags?post=29022"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/embl_taxonomy?post=29022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}