{"id":28504,"date":"2009-12-10T08:00:00","date_gmt":"2009-12-10T07:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=28504"},"modified":"2024-11-14T16:27:23","modified_gmt":"2024-11-14T15:27:23","slug":"from-fruit-fly-wings-to-heart-failure-why-notch","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/from-fruit-fly-wings-to-heart-failure-why-notch\/","title":{"rendered":"From fruit fly wings to heart failure. Why Not(ch)?"},"content":{"rendered":"\n
\"These<\/a>
These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo\u2019s heart muscle cells, the septum between the ventricles of the newborn mouse\u2019s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL. Click on image to download a high resolution version (tiff).<\/figcaption><\/figure><\/div>\n\n\n\n

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch<\/em> signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research<\/em>, scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, are the first to prove that this signalling pathway targets heart muscle cells and thus reveal its crucial role in heart development and repair.<\/p>\n\n\n\n

The Notch<\/em> pathway is a molecular mechanism through which cells communicate with each other. Scientists in Nadia Rosenthal\u2019s group at EMBL used sophisticated genetic mouse models to uncover critical roles for this pathway in heart muscle cells. When they inactivated Notch<\/em> specifically in the heart muscle precursor cells of early mouse embryos, the scientists discovered that the mice developed heart defects. Curiously, increasing Notch<\/em> signalling in the heart muscle cells of older embryos had the same detrimental effect, uncovering different requirements for Notch <\/em>as development proceeds.<\/p>\n\n\n\n

\u201cThe cardiac malformations we observed are characteristic of Alagille syndrome, a human congenital disorder,\u201d said first author Paschalis Kratsios. \u201cTherefore, our findings could help to explain the cardiac symptoms associated with Alagille syndrome and related forms of congenital heart disease.\u201d<\/p>\n\n\n\n

Intriguingly, the scientists were able to improve the cardiac function and survival rate of adult mice that had suffered heart attacks by re-activating Notch<\/em>, suggesting new therapeutic approaches to help the heart recover from damage.<\/p>\n\n\n\n

\u201cOverall, these results highlight the importance of timing and context in biological communication mechanisms\u201d Nadia Rosenthal concludes: \u201cOur findings also lend support to the notion that, in certain situations, redeployment of embryonic signalling pathways could prove beneficial for tissue regeneration in the adult.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…<\/p>\n","protected":false},"author":16,"featured_media":28516,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[55,954,839,1748,514],"embl_taxonomy":[9788,5144],"class_list":["post-28504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-development","tag-mouse","tag-muscle","tag-press-release","tag-rome","embl_taxonomy-embl-rome","embl_taxonomy-epigenetics-and-neurobiology"],"acf":{"vf_locked":false,"featured":true,"color":"#007B53","show_featured_image":true,"article_intro":"

EMBL scientists identify key signalling pathway for heart development and healing<\/h2>\n","article_sources":[{"source_description":"

Kratsios, P., Catela, C., Salimova, E., Huth, M., Berno, V., Rosenthal, N., Mourkioti, F. Distinct roles for cell-autonomous Notch signalling in cardiomyocytes of the embryonic and adult heart. Circulation Research<\/em>. Published online 10th December 2009. DOI: 10.1161\/CIRCRESAHA.109.203034 <\/p>\n","source_link_url":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.109.203034"}],"related_links":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","press_contact":"EMBL Generic","translations":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"741d5d3d-f92f-4eb8-9195-55c96454a36b\";}","parents":[],"name":["EMBL Rome"],"slug":"embl-rome","description":"Where > All EMBL sites > EMBL Rome"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"7ca3ce91-dc32-47ea-8d4b-7a53c3a3a9fd\";i:2;s:36:\"a6e35bb0-c32d-4c9b-aadb-a19b6c7b060f\";}","parents":[],"name":["Epigenetics and neurobiology"],"slug":"epigenetics-and-neurobiology","description":"What > Research Units > Epigenetics and neurobiology"}],"yoast_head":"\nFrom fruit fly wings to heart failure. Why Not(ch)? | EMBL<\/title>\n<meta name=\"description\" content=\"Scientists at EMBL Rome identify key signalling pathway for heart development and healing.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/from-fruit-fly-wings-to-heart-failure-why-notch\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"From fruit fly wings to heart failure. 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