{"id":28324,"date":"2010-04-01T08:00:00","date_gmt":"2010-04-01T06:00:00","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=28324"},"modified":"2024-11-14T16:26:42","modified_gmt":"2024-11-14T15:26:42","slug":"movies-for-the-human-genome","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/","title":{"rendered":"Movies for the human genome"},"content":{"rendered":"\n<p>Name a human gene, and you\u2019ll find a movie online showing you what happens to cells when it is switched off. This is the resource that researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and their collaborators in the Mitocheck consortium are making freely available, as the result of a study in which they have identified the genes involved in mitosis \u2013 the most common form of cell division \u2013 in humans. Published today in <em>Nature<\/em>, their work begins to unravel the molecular workings of one of the most fundamental processes of life: how one cell becomes two.<\/p>\n\n\n\n<p>\u201cWithout mitosis, nothing happens in life, really\u201d, says Jan Ellenberg, who led the study at EMBL, \u201cand when mitosis goes wrong, you get defects like cancer.\u201d<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"973\" height=\"480\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg\" alt=\"Each of these large images of dividing cells is composed of several microscopy images of human cells in which different individual genes were silenced. The smaller images are placed according to genes\u2019 effects: images for genes that affect chromosomes make up the chromosomes (red\/pink), while the mitotic spindle (green) is composed of images for genes that affect it. IMAGE: Thomas Walter &amp; Mayumi Isokane \/ EMBL\" class=\"wp-image-28346\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg 973w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane-300x148.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane-768x379.jpg 768w\" sizes=\"auto, (max-width: 973px) 100vw, 973px\" \/><figcaption class=\"vf-figure__caption\">Each of these large images of dividing cells is composed of several microscopy images of human cells in which different individual genes were silenced. The smaller images are placed according to genes\u2019 effects: images for genes that affect chromosomes make up the chromosomes (red\/pink), while the mitotic spindle (green) is composed of images for genes that affect it. IMAGE: Thomas Walter &#038; Mayumi Isokane \/ EMBL<\/figcaption><\/figure>\n\n\n\n<p>Of the 22,000 genes in each human cell, almost 600 play a part in mitosis, Ellenberg and colleagues found. To uncover which genes are involved in this process, the scientists developed a new method using high-throughput imaging of living cells. They silenced, or inactivated, each of the 22,000 human genes one by one in a different set of cells, and filmed those cells for 48 hours under a microscope. This generated almost 200,000 time-lapse movies of mitosis. Having a person \u2013 or even a group of people \u2013 process such vast amounts of information would be almost impossible, so the scientists created a new computer program that analyses the footage and automatically detects what characteristic defects cells display, and in what order. By grouping genes with similar effects \u2013 for instance, genes which when inactivated led to cells with 2 nuclei instead of one, after division \u2013 they were able to identify genes involved in mitosis, which they confirmed with further experimental assays.<\/p>\n\n\n\n<p>\u201cThe end result is that we now have a very rich resource for the scientific community, as we\u2019re making all the movies and all the analysis data freely available online,\u201d Ellenberg emphasises: \u201cScientists can go to the website, type in the name of their favourite gene, and watch what happens when it is silenced; they can find out what other genes have similar effects \u2013 all in a few mouse clicks, instead of months or years of work in the lab!\u201d<\/p>\n\n\n\n<p>But mitosis is not solved yet, the scientists say. They have yet to uncover exactly how these genes act at the molecular level \u2013 a task which will be tackled by a follow-up project called Mitosys. All data from this follow-up work will also be made freely available online, creating what Ellenberg describes as a \u2018one-stop-shop\u2019 for mitosis research.<\/p>\n\n\n\n<p>In the mean time, the new methodology the EMBL scientists developed to silence all of an organism\u2019s genes in a fast and systematic manner is itself proving a boon to the scientific community.<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"vf-grid | vf-grid__col-4\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.de\/aboutus\/communication_outreach\/media_relations\/2010\/100401_Heidelberg\/colour_control.mov\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"175\" height=\"143\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/cell-division-movie1.jpg\" alt=\"\" class=\"wp-image-28352\"\/><\/a><\/figure>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.de\/aboutus\/communication_outreach\/media_relations\/2010\/100401_Heidelberg\/ogg1.mov\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"175\" height=\"143\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/cell-division-movie2.jpg\" alt=\"\" class=\"wp-image-28354\"\/><\/a><\/figure>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.de\/aboutus\/communication_outreach\/media_relations\/2010\/100401_Heidelberg\/ckap51.mov\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"175\" height=\"143\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/ckap5.jpg\" alt=\"\" class=\"wp-image-28370\"\/><\/a><\/figure>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><a href=\"https:\/\/www.embl.de\/aboutus\/communication_outreach\/media_relations\/2010\/100401_Heidelberg\/negative_control1.mov\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" width=\"175\" height=\"143\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/06\/ckap5-1.jpg\" alt=\"\" class=\"wp-image-28372\"\/><\/a><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"vf-grid | vf-grid__col-2\"><div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-figure__caption\">When no genes are silenced (first video), cell division occurs normally, with each cell giving rise to two. When a gene called OGG1 is silenced (second video), the daughter-cells are unable to separate from each other. The result: individual cells (green) containing more than one nucleus (red). VIDEO: Thomas Walter &amp; Jutta Bulkescher \/ EMBL<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-figure__caption\">When a gene called CKAP5 is silenced, human cells cannot divide properly (first video), as they do when this gene is active (second video). VIDEO: Thomas Walter &amp; Jutta Bulkescher \/ EMBL.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<p>\u201cA year after we developed these new siRNA microarrays,\u201d says Rainer Pepperkok, who led the method\u2019s development at EMBL, \u201cthey\u2019re already in use by over 10 research groups from across Europe.\u201d<\/p>\n\n\n\n<p>The current study looked at HeLa cells, a widely studied line of cancer cells. Now that they have narrowed the search from a daunting 22,000 to a more manageable 600 genes, the scientists would like to investigate how these same genes act in other cancers and in healthy cells, as such comparisons could help to identify markers which could be used for diagnosis or to help make better-informed treatment decisions.<\/p>\n\n\n\n<p>The study was carried out as part of the Mitocheck consortium, coordinated by Jan-Michael Peters at the Research Institute of Molecular Pathology in Vienna, Austria, and the data is available at <a href=\"http:\/\/www.mitocheck.org\" target=\"_blank\" rel=\"noreferrer noopener\">www.mitocheck.org<\/a>. The Mitocheck consortium has also investigated the proteins encoded by these genes, identifying those involved in separating the paired chromosomes during mitosis in a paper published online today in Science.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.embl.org\/news\/science\/picture-release\/\" target=\"_blank\" rel=\"noreferrer noopener\">Click here<\/a> to see related EMBL Picture Release.<\/p>\n\n\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-group__inner-container\"><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Name a human gene, and you\u2019ll find a movie online showing you what happens to cells when it is switched off. This is the resource that researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and their collaborators in the Mitocheck consortium are making freely&hellip;<\/p>\n","protected":false},"author":16,"featured_media":28346,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[64,66,1988,302,41,664,1950,79,703,620,702,398,1748],"embl_taxonomy":[5138,19241,9796],"class_list":["post-28324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-biology","tag-cell-division","tag-confocal-microscopy","tag-ellenberg","tag-genetics","tag-genome","tag-human-genetics","tag-microscopy","tag-mitocheck","tag-mitosis","tag-mitosys","tag-pepperkok","tag-press-release","embl_taxonomy-cell-biology-and-biophysics","embl_taxonomy-ellenberg-group","embl_taxonomy-embl-heidelberg"],"acf":{"show_featured_image":true,"vf_locked":false,"featured":false,"article_intro":"<p>EMBL scientists identify the genes involved in cell division in humans<\/p>\n","article_sources":[{"source_description":"<p>Neuman, B., Walter, T. et al. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. <em>Nature<\/em>, 1 April 2010. DOI:10.1038\/nature08869<\/p>\n","source_link_url":"https:\/\/www.nature.com\/articles\/nature08869"}],"related_links":false,"in_this_article":false,"color":"#007B53","youtube_url":"","mp4_url":"","video_caption":"","translations":false,"press_contact":"EMBL Generic"},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"7ca3ce91-dc32-47ea-8d4b-7a53c3a3a9fd\";i:2;s:36:\"64999cc4-9a7c-4fea-8339-0e2acc990e08\";}","parents":[],"name":["Cell biology and biophysics"],"slug":"cell-biology-and-biophysics","description":"What &gt; Research Units &gt; Cell biology and biophysics"},{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"64999cc4-9a7c-4fea-8339-0e2acc990e08\";i:2;s:36:\"265332fa-964f-466a-a5a1-f3a09c85f3f6\";}","parents":[],"name":["Ellenberg Group"],"slug":"ellenberg-group","description":"What &gt; Cell biology and biophysics &gt; Ellenberg Group"},{"uuid":"a:3:{i:0;s:36:\"b14d3f13-5670-44fb-8970-e54dfd9c921a\";i:1;s:36:\"89e00fee-87f4-482e-a801-4c3548bb6a58\";i:2;s:36:\"ab46b6d4-71d8-49f8-b2f4-b326d4c8ea4e\";}","parents":[],"name":["EMBL Heidelberg"],"slug":"embl-heidelberg","description":"Where &gt; All EMBL sites &gt; EMBL Heidelberg"}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Movies for the human genome | EMBL<\/title>\n<meta name=\"description\" content=\"Scientists at the uropean Molecular Biology Laboratory (EMBL) in Heidelberg identify the genes involved in cell division in humans.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Movies for the human genome | EMBL\" \/>\n<meta property=\"og:description\" content=\"Scientists at the uropean Molecular Biology Laboratory (EMBL) in Heidelberg identify the genes involved in cell division in humans.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2010-04-01T06:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-14T15:26:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"973\" \/>\n\t<meta property=\"og:image:height\" content=\"480\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Guest author(s)\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Guest author(s)\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\"},\"author\":{\"name\":\"Guest author(s)\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b\"},\"headline\":\"Movies for the human genome\",\"datePublished\":\"2010-04-01T06:00:00+00:00\",\"dateModified\":\"2024-11-14T15:26:42+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\"},\"wordCount\":779,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg\",\"keywords\":[\"cell biology\",\"cell division\",\"confocal microscopy\",\"ellenberg\",\"genetics\",\"genome\",\"human genetics\",\"microscopy\",\"mitocheck\",\"mitosis\",\"mitosys\",\"pepperkok\",\"press release\"],\"articleSection\":[\"Science\",\"Science &amp; Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\",\"name\":\"Movies for the human genome | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg\",\"datePublished\":\"2010-04-01T06:00:00+00:00\",\"dateModified\":\"2024-11-14T15:26:42+00:00\",\"description\":\"Scientists at the uropean Molecular Biology Laboratory (EMBL) in Heidelberg identify the genes involved in cell division in humans.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg\",\"width\":973,\"height\":480,\"caption\":\"Each of these large images of dividing cells is composed of several microscopy images of human cells in which different individual genes were silenced. The smaller images are placed according to genes\u2019 effects: images for genes that affect chromosomes make up the chromosomes (red\/pink), while the mitotic spindle (green) is composed of images for genes that affect it. IMAGE: Thomas Walter & Mayumi Isokane \/ EMBL\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.embl.org\/news\/#website\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"name\":\"European Molecular Biology Laboratory News\",\"description\":\"News from the European Molecular Biology Laboratory\",\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"alternateName\":\"EMBL News\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.embl.org\/news\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.embl.org\/news\/#organization\",\"name\":\"European Molecular Biology Laboratory\",\"alternateName\":\"EMBL\",\"url\":\"https:\/\/www.embl.org\/news\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png\",\"width\":300,\"height\":144,\"caption\":\"European Molecular Biology Laboratory\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/embl.org\/\",\"https:\/\/x.com\/embl\",\"https:\/\/www.instagram.com\/embl_org\/\",\"https:\/\/www.linkedin.com\/company\/15813\/\",\"https:\/\/www.youtube.com\/user\/emblmedia\/\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b\",\"name\":\"Guest author(s)\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/300b9a1d66050ae03eaeb99869c6ebb30f5184b9468e92a2b3e7d28bc9cf742d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/300b9a1d66050ae03eaeb99869c6ebb30f5184b9468e92a2b3e7d28bc9cf742d?s=96&d=mm&r=g\",\"caption\":\"Guest author(s)\"},\"description\":\"Guest author(s)\",\"url\":\"https:\/\/www.embl.org\/news\/author\/guest-author\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Movies for the human genome | EMBL","description":"Scientists at the uropean Molecular Biology Laboratory (EMBL) in Heidelberg identify the genes involved in cell division in humans.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/","og_locale":"en_US","og_type":"article","og_title":"Movies for the human genome | EMBL","og_description":"Scientists at the uropean Molecular Biology Laboratory (EMBL) in Heidelberg identify the genes involved in cell division in humans.","og_url":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/","og_site_name":"EMBL","article_publisher":"https:\/\/www.facebook.com\/embl.org\/","article_published_time":"2010-04-01T06:00:00+00:00","article_modified_time":"2024-11-14T15:26:42+00:00","og_image":[{"width":973,"height":480,"url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","type":"image\/jpeg"}],"author":"Guest author(s)","twitter_card":"summary_large_image","twitter_creator":"@embl","twitter_site":"@embl","twitter_misc":{"Written by":"Guest author(s)","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"NewsArticle","@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#article","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/"},"author":{"name":"Guest author(s)","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b"},"headline":"Movies for the human genome","datePublished":"2010-04-01T06:00:00+00:00","dateModified":"2024-11-14T15:26:42+00:00","mainEntityOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/"},"wordCount":779,"publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","keywords":["cell biology","cell division","confocal microscopy","ellenberg","genetics","genome","human genetics","microscopy","mitocheck","mitosis","mitosys","pepperkok","press release"],"articleSection":["Science","Science &amp; Technology"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/","url":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/","name":"Movies for the human genome | EMBL","isPartOf":{"@id":"https:\/\/www.embl.org\/news\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage"},"image":{"@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage"},"thumbnailUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","datePublished":"2010-04-01T06:00:00+00:00","dateModified":"2024-11-14T15:26:42+00:00","description":"Scientists at the uropean Molecular Biology Laboratory (EMBL) in Heidelberg identify the genes involved in cell division in humans.","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/science\/movies-for-the-human-genome\/#primaryimage","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","width":973,"height":480,"caption":"Each of these large images of dividing cells is composed of several microscopy images of human cells in which different individual genes were silenced. The smaller images are placed according to genes\u2019 effects: images for genes that affect chromosomes make up the chromosomes (red\/pink), while the mitotic spindle (green) is composed of images for genes that affect it. IMAGE: Thomas Walter & Mayumi Isokane \/ EMBL"},{"@type":"WebSite","@id":"https:\/\/www.embl.org\/news\/#website","url":"https:\/\/www.embl.org\/news\/","name":"European Molecular Biology Laboratory News","description":"News from the European Molecular Biology Laboratory","publisher":{"@id":"https:\/\/www.embl.org\/news\/#organization"},"alternateName":"EMBL News","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.embl.org\/news\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.embl.org\/news\/#organization","name":"European Molecular Biology Laboratory","alternateName":"EMBL","url":"https:\/\/www.embl.org\/news\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/","url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","contentUrl":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2025\/09\/EMBL_logo_colour-1-300x144-1.png","width":300,"height":144,"caption":"European Molecular Biology Laboratory"},"image":{"@id":"https:\/\/www.embl.org\/news\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/embl.org\/","https:\/\/x.com\/embl","https:\/\/www.instagram.com\/embl_org\/","https:\/\/www.linkedin.com\/company\/15813\/","https:\/\/www.youtube.com\/user\/emblmedia\/"]},{"@type":"Person","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/b4d9366b2ebe691c4015c64c3619205b","name":"Guest author(s)","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.embl.org\/news\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/300b9a1d66050ae03eaeb99869c6ebb30f5184b9468e92a2b3e7d28bc9cf742d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/300b9a1d66050ae03eaeb99869c6ebb30f5184b9468e92a2b3e7d28bc9cf742d?s=96&d=mm&r=g","caption":"Guest author(s)"},"description":"Guest author(s)","url":"https:\/\/www.embl.org\/news\/author\/guest-author\/"}]}},"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"fimg_url":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","featured_image_src":"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2010\/04\/dividing-cells-walter-isokane.jpg","_links":{"self":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/28324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/comments?post=28324"}],"version-history":[{"count":17,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/28324\/revisions"}],"predecessor-version":[{"id":28378,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/posts\/28324\/revisions\/28378"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media\/28346"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/media?parent=28324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/categories?post=28324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/tags?post=28324"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/news\/wp-json\/wp\/v2\/embl_taxonomy?post=28324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}