{"id":25046,"date":"2013-07-11T13:02:33","date_gmt":"2013-07-11T11:02:33","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=25046"},"modified":"2024-03-26T00:30:08","modified_gmt":"2024-03-25T23:30:08","slug":"how-to-build-your-gate","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/how-to-build-your-gate\/","title":{"rendered":"How to build your gate"},"content":{"rendered":"\n<div\n\n  \n  \n  class=\"vf-box vf-box--inlay\">\n  <h3 class=\"vf-box__heading\">In a nutshell:<\/h3>\n  <p class=\"vf-box__text\">&#8211; Decade-old controversy over structure of nuclear pore solved<br \/>&#8211; New method combines thousands of super-resolution microscopy images to reach a precision below one nanometre<br \/>&#8211; Bridges gap in available techniques to determine how individual components fit together to build large molecular machines<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-inline-start   size-medium\"><a href=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/05\/130711_Heidelberg.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/05\/130711_Heidelberg-300x300.jpg\" alt=\"\" class=\"wp-image-25048\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/05\/130711_Heidelberg-300x300.jpg 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/05\/130711_Heidelberg-150x150.jpg 150w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/05\/130711_Heidelberg-768x768.jpg 768w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/05\/130711_Heidelberg.jpg 800w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption class=\"vf-figure__caption\">By combining thousands of super-resolution microscopy images, EMBL scientists have solved a decade-old controversy over how the pieces that form the nuclear pore\u2019s ring are arranged.\nCredit: EMBL\/A. Szymborska &#038; J.Ellenberg<\/figcaption><\/figure><\/div>\n\n\n\n<p>It&#8217;s a parent&#8217;s nightmare: opening a Lego set and being faced with 500 pieces, but no instructions on how to assemble them into the majestic castle shown on the box. Thanks to a new approach by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, researchers studying large sets of molecules with vital roles inside our cells can now overcome a similar problem. In a study published online today in&nbsp;<em>Science<\/em>, the scientists used super-resolution microscopy to solve a decade-long debate about the structure of the nuclear pore complex, which controls access to the genome by acting as a gate into the cell\u2019s nucleus.<\/p>\n\n\n\n<p>Like the flummoxed parent staring at the image on the box, scientists knew the gate\u2019s overall shape, from electron tomography studies. And thanks to techniques like X-ray crystallography and single particle electron microscopy, they knew that the ring which studs the nucleus\u2019 wall and controls what passes in and out is formed by sixteen or thirty-two copies of a Y-shaped building block. They even knew that each Y is formed by nine proteins. But how the Ys are arranged to form a ring was up for debate.<\/p>\n\n\n\n<p>\u201cWhen we looked at our images, there was no question: they have to be lying head-to-tail around the hole\u201d says Anna Szymborska, who carried out the work.<\/p>\n\n\n\n<p>To figure out how the Ys were arranged, the EMBL scientists used fluorescent tags to label a series of points along each of the Y\u2019s arms and tail, and analysed them under a super-resolution microscope. By combining images from thousands of nuclear pores, they were able to obtain measurements of where each of those points was, in relation to the pore\u2019s centre, with a precision of less than a nanometre \u2013 a millionth of a millimetre. The result was a rainbow of rings whose order and spacing meant the Y-shaped molecules in the nuclear pore must lie in an orderly circle around the opening, all with the same arm of the Y pointing toward the pore\u2019s centre.<\/p>\n\n\n\n<p>Having resolved this decade-old controversy, the scientists intend to delve deeper into the mysteries of the nuclear pore \u2013 determining whether the circle of Ys is arranged clockwise or anticlockwise, studying it at different stages of assembly, looking at other parts of the pore, and investigating it in three dimensions.<\/p>\n\n\n\n<p>\u201cThere\u2019s been a lot of interest from other groups,\u201d says Jan Ellenberg, who led the work, \u201cso we\u2019ll soon be looking into a number of other molecular puzzles, like the different \u2018machines\u2019 that allow a cell to divide, which are also built from hundreds of pieces.\u201d<\/p>\n\n\n\n<p>The work was carried out in collaboration with John Briggs\u2019 group at EMBL, who helped adapt the image averaging algorithms from electron microscopy to super-resolution microscopy, and Volker Cordes at the Max Planck Institute for Biophysical Chemisty in G\u00f6ttingen, Germany, who provided antibodies and advice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It&#8217;s a parent&#8217;s nightmare: opening a Lego set and being faced with 500 pieces, but no instructions on how to assemble them into the majestic castle shown on the box. Thanks to a new approach by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany,&hellip;<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[79,1790],"embl_taxonomy":[],"class_list":["post-25046","post","type-post","status-publish","format-standard","hentry","category-science","category-science-technology","tag-microscopy","tag-nuclear-pore"],"acf":{"show_featured_image":false,"vf_locked":false,"featured":false,"article_intro":"<p>New approach solves large molecular puzzles<\/p>\n","article_sources":[{"source_description":"<p>Szymborska, A., Marco, A., Daigle, N., Cordes, V.C., Briggs, J.A.G. &#038; Ellenberg, J. Nuclear Pore Scaffold Structure Analyzed by Super-Resolution Microscopy and Particle Averaging. Published online in <em>Science Express<\/em> on 11 July 2013. DOI: 10.1126\/science.1240672.<\/p>\n","source_link_url":"http:\/\/www.issuu.com\/embl\/docs\/ar_12_13_all_web?e=1873350\/3795721"}],"related_links":[{"link_description":"How many copies of each piece build the nuclear pore? The Beck and Lemke labs did the math.","link_url":"http:\/\/www.issuu.com\/embl\/docs\/ar_12_13_all_web?e=1873350\/3795721"}],"in_this_article":false,"color":"#007B53","youtube_url":"","mp4_url":"","video_caption":"","translations":false,"press_contact":"EMBL Generic"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How to build your gate | EMBL<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/how-to-build-your-gate\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How to build your gate | EMBL\" \/>\n<meta property=\"og:description\" content=\"It&#8217;s a parent&#8217;s nightmare: opening a Lego set and being faced with 500 pieces, but no instructions on how to assemble them into the majestic castle shown on the box. 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