{"id":2339,"date":"2014-10-23T15:08:26","date_gmt":"2014-10-23T13:08:26","guid":{"rendered":"http:\/\/news.embl.de\/?p=2339"},"modified":"2024-11-14T16:31:16","modified_gmt":"2024-11-14T15:31:16","slug":"1410_cells_huddle","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/1410_cells_huddle\/","title":{"rendered":"Chamber of secrets"},"content":{"rendered":"\n

The study, published today in Nature<\/em>, is the first demonstration that the way cells organise themselves influences their ability to communicate. The researchers propose that this strategy, which they discovered in developing zebrafish, could be much more widespread, influencing processes like wound repair, organ formation and even cancer.<\/p>\n\n\n\n

\u201cEverybody can speak, everybody can listen, but what\u2019s said in the group stays in the group,\u201d explains Sevi Durdu, who carried out the research, \u201cby huddling together, these cells trap and concentrate a signal to communicate only amongst themselves.\u201d<\/p>\n\n\n\n

\"By
By huddling together, groups of cells can trap a signal molecule (green), to communicate within a restricted group. IMAGE: EMBL\/DURDU<\/figcaption><\/figure><\/div>\n\n\n\n

Durdu, a PhD student in Darren Gilmour\u2019s lab at EMBL<\/a>, found this behaviour in specific groups of cells in the zebrafish: the cells that will develop into the animal\u2019s \u2018lateral line\u2019, a series of ear-like organs along the fish\u2019s flank that allow it to sense changes in water pressure. As a zebrafish develops, a mass of cells moves along the developing animal\u2019s side. At the point where one of these organs should form, a group of cells at the rear assembles into a huddle and stops, eventually developing into the organ. The rest of the cells, meanwhile, have moved on, until another group stops to form another organ, and so on. The cells that group together and stop to form the future organ also change shape, going from flat, crawling cells to upright, tear-shaped cells that come together like cloves in a bulb of garlic. Durdu found that these \u2018garlic cloves\u2019 huddle around a shared space, or lumen, in which they trap a molecule cells use to communicate: FGF.<\/p>\n\n\n\n

\u201cNormally, FGF acts as a long-range communication signal. In the lateral line, we find that most of this signal is normally just wafting over the cells\u2019 heads,\u201d says Gilmour. \u201cBut when cells get together and huddle they can trap and concentrate this signal in their shared lumen, and make a decision that the others can\u2019t: they stop moving.\u201d<\/p>\n\n\n\n

The EMBL scientists found that, by enabling a group of cells to increase the concentration of FGF they are in contact with, the shared lumen plays a critical role in determining when and where the huddles stop moving. When the scientists increased the concentration of FGF, cell huddles came to a standstill more abruptly, forming organs that were closer together. And when they decreased the level of FGF, huddles continued to migrate for longer and formed organs that were further apart.<\/p>\n\n\n