{"id":18917,"date":"2020-03-17T14:15:12","date_gmt":"2020-03-17T13:15:12","guid":{"rendered":"https:\/\/www.embl.org\/news\/?p=18917"},"modified":"2024-03-22T11:27:05","modified_gmt":"2024-03-22T10:27:05","slug":"2020-embl-alumni-awards","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/alumni\/2020-embl-alumni-awards\/","title":{"rendered":"2020 EMBL Alumni Award winners announced"},"content":{"rendered":"\n<p>The winners of the 2020 <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.embl.de\/aboutus\/alumni\/alumni-awards\/index.html\" target=\"_blank\">EMBL Alumni Awards<\/a> have been selected. Giorgia Guglielmi wins the John Kendrew Award for her journalism work focusing on the intersection of science and society, while John van der Oost wins the Lennart Philipson Award for his contributions to our understanding of the genome editing tool known as CRISPR\u2013Cas. The awards will be presented as part of the <a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.de\/aboutus\/alumni\/events-networks\/\" target=\"_blank\">EMBL World Alumni Day<\/a> celebrations, which will be live-streamed on 17 July. Here, the awardees discuss some of the defining moments in their careers.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Combining two passions<\/h3>\n\n\n\n<p>Giorgia Guglielmi has always been fascinated by how an embryo develops into a mature organism. In 2011, she joined the group of Stefano De Renzis at EMBL Heidelberg to investigate embryonic development. For her PhD research, Giorgia worked with an experimental tool that uses laser light to evoke changes in cell behaviour. \u201cNobody had used this technique before to understand how cells behave in a whole organism during development,\u201d Giorgia recalls. \u201cWhen we published our results, researchers immediately started asking for help to do this themselves.\u201d<\/p>\n\n\n\n<p>Besides her passion for science, Giorgia felt a strong interest in communication throughout her studies. \u201cIn high school, my dream was to become a journalist. Then I fell in love with science,\u201d she says. \u201cIt was at EMBL that I realised I could combine my passions.\u201d She started writing articles for <a href=\"https:\/\/www.embl.org\/news\/author\/giorgia-guglielmi\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">EMBL\u2019s news website<\/a> and found that science communication was her true calling. In 2016, having earned her PhD, she applied successfully for a spot in MIT\u2019s prestigious Graduate Program in Science Writing. In the thesis she wrote as part of the course, Giorgia investigated how misinformation had led to the death of millions of olive trees in the Italian region of Apulia, where she was born. \u201cI travelled to Italy, interviewed scientists, conspiracy theorists, government officials, and farmers, and had to balance all the information with creativity and style in writing,\u201d she explains. \u201cThat was a huge effort.\u201d<\/p>\n\n\n\n<p>The hard work paid off. Giorgia\u2019s report won her an MIT Stanley Klein Prize for Scientific Writing. After graduating from MIT in 2017, she had the opportunity to work in the newsrooms of <em>Science<\/em> and <em>Nature<\/em>. \u201cThere I realised that I really like being a science journalist,\u201d she says. \u201cWe get to cover the most exciting and important topics of the day.\u201d<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Striving for facts<\/h3>\n\n\n\n<p>Covering the societal aspects of scientific research is at the heart of Giorgia\u2019s work. She wrote about alleged <a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06967-0\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">irregularities in a homeopathy study<\/a> that was later retracted, and reported about a <a href=\"https:\/\/www.nature.com\/articles\/d41586-018-07464-0\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">donation from the Italian National Order of Biologists (ONB) to a group that questions the safety of vaccines<\/a>. The donation has since been withdrawn. \u201cThis kind of work can be stressful, but it\u2019s very satisfying to see that my stories are read by thousands of people, and that they sometimes even influence science policy,\u201d says Giorgia. She now works as a freelance science journalist in Cambridge, Massachusetts. Her writing has recently focused on diversity, exploring gender imbalances in science and the under-representation of indigenous populations and other marginalised groups in genomic studies.<\/p>\n\n\n\n<p>Looking back, Giorgia believes that her scientific training prepared her well for working as a science journalist. \u201cAs a scientist, I\u2019m equipped with the skills to look for evidence and base my conclusions on facts,\u201d she explains. \u201cStefano and my mentors at MIT have always supported me, and at <em>Nature<\/em> and <em>Science<\/em> I got to work with great editors and reporters.\u201d Giorgia sees receiving the John Kendrew Award as a signal that rigorous science communication is important and valued. \u201cI\u2019m grateful to the committee for supporting independent science journalism. That\u2019s a huge encouragement for me to keep going.\u201d<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Understanding bacteria<\/h3>\n\n\n\n<p>John van der Oost has spent most of his scientific career studying bacterial enzymes. Having obtained his PhD from Vrije Universiteit (VU) Amsterdam, he joined the lab of structural biologist Matti Saraste at the University of Helsinki. Shortly afterwards, he moved with Matti to EMBL Heidelberg. \u201cI had never seen such an international, well-organised, and stimulating research environment,\u201d John recalls. After returning to VU Amsterdam for a postdoc position, he started his own research group at the University of Wageningen, also in the Netherlands.<\/p>\n\n\n\n<p>While studying <em>Sulfolobus<\/em>, a microorganism that lives in extreme environments such as hot springs, John and his team discovered unexpected stretches of repetitive DNA among its genes. <a href=\"https:\/\/doi.org\/10.1073\/pnas.141222098\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">The finding became a side note<\/a> and was not investigated further. Several years later, Eugene Koonin from the National Center for Biotechnology Information in Bethesda, Maryland, visited Wageningen. The seminar he gave during his visit got John thinking again about the stretches of bacterial DNA. These DNA regions appeared to contain fragments of viral DNA, an adaptive defence system against bacteriophages \u2013 viruses that infect bacteria. John had stumbled upon the system now known as <a href=\"https:\/\/www.embl.org\/news\/science\/wielding-the-genetic-scissors\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">CRISPR\u2013Cas<\/a>: a powerful genome editing tool that biologists can use to target a specific DNA region.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Enabling genome editing<\/h3>\n\n\n\n<p>\u201cI had just received a major grant, so I decided to use part of the money to study CRISPR,\u201d John explains. In the years that followed, he and his team made a series of seminal discoveries that explain how the CRISPR\u2013Cas system works. The researchers were able to show that CRISPR-derived small RNA molecules are used as guides to target DNA, and not RNA as initially assumed. They also figured out the roles of CRISPR-associated enzymes called Cas nucleases: specialised proteins that are targeted to a specific DNA sequence by the CRISPR RNA and cut the DNA at that point \u2013 a powerful method to destroy bacteriophage DNA. Most importantly, John and his colleagues managed to transplant the entire CRISPR\u2013Cas system to another bacterial strain and succeeded in programming it to protect the recipient bacteria against a specific bacteriophage \u2013 a \u2018flu shot for bacteria\u2019.<\/p>\n\n\n\n<p>With these results, John had found the key ingredients to enable genome editing applications. The <a href=\"https:\/\/doi.org\/10.1126\/science.1159689\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">results were published in 2008<\/a>, and \u2013 after some further insights were revealed \u2013 a patent was filed in 2011. However, John\u2019s CRISPR\u2013Cas system required the activity of six Cas proteins. \u201cHalf a year later, the teams of Virgis \u0160ik\u0161nys, Jennifer Doudna, and <a href=\"https:\/\/www.embl.org\/news\/science\/1608-charpentier\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">Emmanuelle Charpentier<\/a> caught up with us,\u201d John recalls. \u201cThey used the Cas9 protein, which combines all the functionalities in a single protein, so it\u2019s much easier to work with.\u201d It took John and colleagues another eight years to optimise their system to work in human cells, but they <a href=\"https:\/\/doi.org\/10.1038\/s41587-019-0310-0\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">finally succeeded in 2019<\/a>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Keeping an open mind<\/h3>\n\n\n\n<p>Meanwhile, John has continued to explore bacterial genome editing mechanisms. \u201cMy group is bigger than ever, and 10 to 15 people in the lab are working on several CRISPR-related systems. We characterise and optimise new and existing systems and design applications, mainly in microorganisms,\u201d he says. The potential applications are manifold. CRISPR has already revolutionised life science research and is likely to have a similar impact on biotechnology and health care.<\/p>\n\n\n\n<p>Reflecting on his career, John points out the huge impact that chance and unexpected developments have played. \u201cI could never have predicted that I would end up where I am now, and I think very few people can really plan far into the future. It\u2019s a matter of keeping your eyes open and looking for opportunities. But I think this uncertainty is also what makes science one big adventure.\u201d<\/p>\n\n\n<hr class=\"vf-divider\"\/>\n\n\n<p><em>Nominations and applications for the 2021 John Kendrew and Lennart Philipson Awards are now open. Please&nbsp;<a href=\"https:\/\/www.embl.de\/aboutus\/alumni\/alumni-awards\/index.html\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">click here<\/a>&nbsp;to find out more and submit a nomination or application.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Committee recognises outstanding contributions of EMBL alumni to science journalism and genome editing<\/p>\n","protected":false},"author":81,"featured_media":18919,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5,17597],"tags":[80,692,628,629,1315],"embl_taxonomy":[],"class_list":["post-18917","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alumni","category-embl-announcements","tag-alumni","tag-alumni-award","tag-crispr","tag-genome-editing","tag-science-communication"],"acf":{"article_intro":"<p>Committee recognises outstanding contributions of EMBL alumni to science journalism and genome editing<\/p>\n","featured":true,"article_sources":false,"related_links":[{"link_description":"EMBL Alumni Awards","link_url":"https:\/\/www.embl.de\/aboutus\/alumni\/alumni-awards\/index.html"},{"link_description":"Giorgia Guglielmi\u2019s author page on EMBL News","link_url":"https:\/\/www.embl.org\/news\/author\/giorgia-guglielmi\/"},{"link_description":"Wielding the genetic scissors: What CRISPR may bring for the future of biology, and how it is used at EMBL","link_url":"https:\/\/news.embl.de\/science\/wielding-the-genetic-scissors\/"}],"color":"#007B53","link_color":"#fff","vf_locked":false,"show_featured_image":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","translations":false,"press_contact":"None"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - 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