{"id":18355,"date":"2020-02-05T19:01:11","date_gmt":"2020-02-05T18:01:11","guid":{"rendered":"https:\/\/news.embl.de\/?p=18355"},"modified":"2024-08-29T14:21:19","modified_gmt":"2024-08-29T12:21:19","slug":"pan-cancer","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/pan-cancer\/","title":{"rendered":"The Pan-Cancer project"},"content":{"rendered":"\n<p>An international team, including scientists from EMBL and EMBL-EBI, has completed the most comprehensive study of whole cancer genomes to date, significantly improving our fundamental understanding of cancer and marking out new directions for its diagnosis and treatment. A key finding is that it\u2019s possible to identify mutations in the genome that occurred years, or even decades, before a tumour appears \u2013 theoretically opening a window of opportunity for early cancer detection. The results of the project are published today in more than 20 papers in Nature and its affiliated journals.<\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"http:\/\/www.embl.de\/pancancer\/\"><span style=\"font-weight: 400;\">Pan-Cancer Analysis of Whole Genomes project<\/span><\/a><span style=\"font-weight: 400;\"> is a collaboration involving more than 1300 scientists and clinicians from 37 countries. It involved analysis of more than 2600 genomes of 38 different tumour types, creating a huge resource of primary cancer genomes. This was the starting point for 16 working groups to study multiple aspects of cancer development, causation, progression, and classification. \u201cThis huge international study was only possible due to the work and collaboration of more than a thousand researchers and clinicians across the world, and I would like to thank everyone involved,\u201d says Pan-Cancer steering committee member Dr. Jan Korbel from EMBL Heidelberg.<\/span><\/p>\n\n\n<div\n  class=\"vf-embed vf-embed--custom-ratio\"\n\n  style=\"--vf-embed-max-width: 100%;\n    --vf-embed-custom-ratio-x: 640;\n    --vf-embed-custom-ratio-y: 360;\"><iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/rgkmBqpAjQE\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n\n\n\n<p class=\"vf-u-margin__bottom--xl\"><\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image alignnone\"><a href=\"https:\/\/news.embl.de\/wp-content\/uploads\/2020\/02\/Studied-Cancers-EMBL.png\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"856\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2020\/02\/Studied-Cancers-EMBL-1024x856.png\" alt=\"\" class=\"wp-image-18356\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/Studied-Cancers-EMBL-1024x856.png 1024w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/Studied-Cancers-EMBL-300x251.png 300w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/Studied-Cancers-EMBL-768x642.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"vf-figure__caption\">Studied cancers in the Pan-Cancer project.<br \/>Credit: Rayne Zaayman-Gallant\/EMBL<\/figcaption><\/figure>\n\n\n\n<p><span style=\"font-weight: 400;\">Most previous studies have focused on the 1% of the genome that codes for proteins. The Pan-Cancer project explored in considerably greater detail the remaining 99% of the genome.<\/span><span style=\"font-weight: 400;\"> \u201cThere have been several studies in the past dealing with cancer genomes, but these studies typically looked at protein-coding genes only,\u201d<\/span><span style=\"font-weight: 400;\"> explains Dr. Sebastian Waszak, former postdoc at EMBL. <\/span><span style=\"font-weight: 400;\">\u201cThese are only a small fraction of our genetic blueprint. Through the Pan-Cancer project we can now better understand that cancer-causing mutations occur not only in genes but also in regions that switch genes on and off.\u201d<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The Pan-Cancer project has extended and advanced methods for analysing cancer genomes. By applying them to this large dataset, it has revealed new knowledge about cancer biology and confirmed important findings from previous studies.&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">The first wave of results is published today and shows that the cancer genome is finite and knowable, but enormously complicated. <\/span><span style=\"font-weight: 400;\">\u201cCancer is complex, and we need even more data to fully understand it. However, I\u2019m positive that the cancer genome is solvable: it can be understood!\u201d<\/span><span style=\"font-weight: 400;\"> explains Jan Korbel. By combining sequencing of the whole cancer genome with a suite of analysis tools, the researchers were able to characterise every genetic change found in a cancer, all the processes that have generated those mutations, and even the order of key events during a cancer\u2019s life history.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Researchers are close to cataloguing all of the biological pathways involved in cancer and having a fuller picture of their actions in the genome. At least one causal mutation was found in almost all of the cancers analysed, and the processes that generate mutations were found to be hugely diverse \u2013 from changes in single letters of the DNA code to the reorganisation of whole chromosomes. Multiple novel regions of the genome controlling how genes switch on and off were identified as targets of cancer-causing mutations.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u201cThis work is helping to answer a longstanding medical difficulty: why two patients with what appear to be the same cancer can have very different outcomes to the same drug treatment. We show that the reasons for these different behaviours are written in the DNA. The genome of each patient\u2019s cancer is unique, but there are a finite set of recurring patterns, so with large enough studies we can identify all these patterns to optimise diagnosis and treatment,<\/span><span style=\"font-weight: 400;\">\u201d says steering committee member Dr. Peter Campbell from the <\/span><span style=\"font-weight: 400;\"><a href=\"https:\/\/www.sanger.ac.uk\/\">Wellcome Sanger Institute<\/a> in the UK<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Through a method of \u2018carbon dating\u2019, Pan-Cancer researchers \u2013 involving Dr. Moritz Gerstung and his group from EMBL-EBI in Hinxton \u2013 discovered that it is possible to identify mutations in the genome that occurred years, or sometimes even decades, before the tumour appears. Theoretically, this opens a window of opportunity for early cancer detection.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">&#8220;We have learned that cancer is the endpoint of a lifelong evolutionary process that drives our cells. This process is fuelled by mutations in the cells\u2019 genomes. These mutations occur as we age. Usually, there are no consequences to these mutations, but sometimes the consequences can be dramatic,\u201d <\/span><span style=\"font-weight: 400;\">says Gerstung.<\/span><span style=\"font-weight: 400;\"> \u201cThis process usually culminates within the decades prior to cancer diagnosis, but in some cases we have been able to identify alterations as old as the patient.\u201d<\/span><span style=\"font-weight: 400;\">&nbsp;<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">Tumour types can be accurately identified by examining the patterns of genetic changes seen throughout the genome. This has the potential to aid diagnosis of a patient\u2019s cancer where its type could not be determined by conventional clinical tests. Knowledge of the exact tumour type could also help to tailor treatments for specific patients.<\/span><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">\u201cThe results from the Pan-Cancer project will help patients that already have cancer to the extent that we now have a much better molecular explanation for what might be driving their cancer. So we now have a better panorama of which mutations likely cause their disease. And if we know what&#8217;s causing the disease then we have a better chance of treating it,\u201d<\/span><span style=\"font-weight: 400;\"> says Joachim Weischenfeldt, group leader at the Biotech Research &amp; Innovation Centre in Copenhagen.<\/span><\/p>\n\n\n<div\n  class=\"vf-embed vf-embed--custom-ratio\"\n\n  style=\"--vf-embed-max-width: 100%;\n    --vf-embed-custom-ratio-x: 640;\n    --vf-embed-custom-ratio-y: 360;\"><iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/DZQcWXROfOQ\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n\n\n\n<p class=\"vf-u-margin__bottom--xl\"><\/p>\n\n\n\n<p><span style=\"font-weight: 400;\">On top of the discoveries that have already been made, the Pan-Cancer project equips scientists with a comprehensive resource for cancer genomics research, including the raw genome sequencing data, software for cancer genome analysis, and multiple interactive websites exploring various aspects of the Pan-Cancer project data. \u201cWe have established a resource for the scientific community to drive forward cancer research,\u201d says Jan Korbel.<\/span><\/p>\n\n\n\n<div\n  class=\"vf-box vf-box--inlay\">\n\n  <h3 class=\"vf-box__heading\">Related links<\/h3>\n  <p class=\"vf-box__text\"><a href=\"http:\/\/www.embl.de\/pancancer\">EMBL Pan-Cancer landing page<\/a><br \/><a href=\"http:\/\/www.embl.org\/pancancer\/faq\">Frequently Asked Questions on the Pan-Cancer project<\/a><br \/><a href=\"https:\/\/oc.embl.de\/index.php\/s\/hCcR2Qaro2gaOnl\">Pan-Cancer visuals<br \/><\/a><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-cancer-drivers\">Research highlight: Scientists identify new genetic drivers of cancer<\/a><br \/><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-protecting-data\">Research highlight: Protecting data in the cloud<\/a><br \/><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-structural-variations\">Research highlight: Studying DNA rearrangement to understand cancer<\/a><br \/><a href=\"https:\/\/news.embl.de\/science\/pan-cancer-molecular-clock\/\">Research highlight: Finding genetic cancer risks<\/a><br \/><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-butler\/\">Research highlight: Rapid and safe analysis of thousands of human genomes in the cloud<\/a><br \/><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-evolutionary-history\">Research highlight: Cancer mutations occur decades before diagnosis<\/a><br \/><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-chromosome-shattering\">Research highlight: Chromothripsis in human cancer<\/a><br \/><a href=\"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-rna-alterations\">Research highlight: Characterising RNA alterations in cancer<\/a><\/p>\n<\/div>\n\n\n\n<hr class=\"vf-divider\"\/>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"de\">EMBL hilft bei der Erstellung der bisher umfassendsten Karte der Krebsgenome<\/h2>\n\n\n\n<p>Ein internationales Team, darunter Wissenschaftler des Europ\u00e4ischen Laboratoriums f\u00fcr Molekularbiologie (EMBL), hat die bisher umfassendste Studie \u00fcber Krebsgenome abgeschlossen, wodurch unser grundlegendes Verst\u00e4ndnis von Krebs deutlich verbessert wird und neue Wege f\u00fcr seine Diagnose und Behandlung aufgezeigt werden. Eine wichtige Erkenntnis ist, dass es m\u00f6glich ist, Mutationen im Genom zu identifizieren, die Jahre oder sogar Jahrzehnte vor dem Auftreten eines Tumors aufgetreten sind \u2013 was theoretisch eine neue M\u00f6glichkeit zur Krebsfr\u00fcherkennung werden k\u00f6nnte. Die Ergebnisse des Projekts werden heute in mehr als 20 Artikeln \u2013 9 davon enthalten wichtige Beitr\u00e4ge des EMBL \u2013 in Nature und den angeschlossenen Zeitschriften ver\u00f6ffentlicht.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"620\" height=\"425\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg\" alt=\"\" class=\"wp-image-18351\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg 620w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib-300x206.jpg 300w\" sizes=\"auto, (max-width: 620px) 100vw, 620px\" \/><figcaption class=\"vf-figure__caption\">Credit:&nbsp;Rayne Zaayman-Gallant\/EMBL<\/figcaption><\/figure>\n\n\n\n<p>Das Projekt &#8220;Pan-Cancer Analysis of Whole Genomes&#8221; ist eine Zusammenarbeit von mehr als 1300 Wissenschaftlern und Klinikern aus 37 L\u00e4ndern. Es umfasste die Analyse von mehr als 2600 Genomen von 38 verschiedenen Tumorarten, wodurch eine riesige Ressource an prim\u00e4ren Krebsgenomen geschaffen wurde. Dies war der Ausgangspunkt f\u00fcr 16 Arbeitsgruppen, die verschiedene Aspekte der Krebsentstehung, -verursachung, -progression und -klassifizierung untersuchen. \u201eDiese riesige internationale Studie war nur dank der Arbeit und Zusammenarbeit von mehr als tausend Forschern und Klinikern aus aller Welt m\u00f6glich, und ich m\u00f6chte allen Beteiligten danken\u201c, sagt Dr. Jan Korbel, Mitglied des Pan-Cancer-Lenkungsausschusses und Gruppenleiter am EMBL in Heidelberg.<\/p>\n\n\n<div\n  class=\"vf-embed vf-embed--custom-ratio\"\n\n  style=\"--vf-embed-max-width: 100%;\n    --vf-embed-custom-ratio-x: 640;\n    --vf-embed-custom-ratio-y: 360;\"><iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/lhC0-8wc2ns\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Die meisten bisherigen Studien haben sich auf das 1% des Genoms konzentriert, welches Proteine kodiert. Das Pan-Cancer-Projekt untersuchte detailliert die verbleibenden 99% des Genoms. \u201eEs gab in der Vergangenheit mehrere Studien, die sich mit Krebsgenomen befassten, aber diese Studien untersuchten in der Regel nur die proteincodierenden Gene\u201c, erkl\u00e4rt Dr. Sebastian Waszak, ehemaliger Postdoc am EMBL. \u201eDies ist nur ein kleiner Bruchteil unseres genetischen Bauplans. Durch das Pan-Cancer-Projekt k\u00f6nnen wir nun besser verstehen, dass krebsverursachende Mutationen nicht nur in Genen, sondern auch in Regionen auftreten, die Gene an- und ausschalten.\u201c<\/p>\n\n\n\n<p>Das Pan-Cancer-Projekt hat die Methoden zur Analyse von Krebsgenomen erweitert und weiterentwickelt. Durch ihre Anwendung auf diesen gro\u00dfen Datensatz hat es neue Erkenntnisse \u00fcber die Krebsbiologie gewonnen und wichtige Erkenntnisse aus fr\u00fcheren Studien best\u00e4tigt.<\/p>\n\n\n\n<p>Die erste Welle von Ergebnissen wird heute ver\u00f6ffentlicht und zeigt, dass das Krebsgenom zwar endlich, aber enorm kompliziert ist. \u201eKrebs ist komplex, und wir brauchen noch mehr Daten, um ihn vollst\u00e4ndig zu verstehen. Ich bin jedoch \u00fcberzeugt, dass das Krebsgenom l\u00f6sbar ist: es kann verstanden werden\u201c, erkl\u00e4rt Jan Korbel. Durch die Kombination der Sequenzierung des gesamten Krebsgenoms mit einer Reihe von Analysewerkzeugen waren die Forscher in der Lage, jede bei einem Krebs gefundene genetische Ver\u00e4nderung, alle Prozesse, die diese Mutationen hervorgerufen haben, und sogar die Reihenfolge der Schl\u00fcsselereignisse in der Lebensgeschichte eines Krebses zu charakterisieren.<\/p>\n\n\n\n<p>Die Forscher stehen damit kurz davor, alle an Krebs beteiligten biologischen Pfade zu katalogisieren und sind dabei sich ein vollst\u00e4ndigeres Bild von ihren Aktionen im Genom zu machen. Bei fast allen analysierten Krebsarten wurde mindestens eine kausale Mutation gefunden, und es wurde festgestellt, dass die Prozesse, die Mutationen hervorrufen, \u00e4u\u00dferst vielf\u00e4ltig sind \u2013 von Ver\u00e4nderungen einzelner Buchstaben des DNA-Codes bis hin zur Neuordnung ganzer Chromosomen. Mehrere neue Regionen des Genoms, die das An- und Ausschalten von Genen steuern, wurden als Ziel von krebserzeugenden Mutationen identifiziert.<\/p>\n\n\n\n<p>\u201eDiese Arbeit hilft, eine seit langem bestehende medizinische Frage zu beantworten: Warum zwei Patienten mit scheinbar demselben Krebs sehr unterschiedliche Ergebnisse bei derselben medikament\u00f6sen Behandlung haben k\u00f6nnen. Wir zeigen, dass die Gr\u00fcnde f\u00fcr diese unterschiedlichen Verhaltensweisen in die DNA geschrieben sind. Das Genom eines jeden Patienten ist einzigartig, aber es gibt eine endliche Anzahl wiederkehrender Muster, so dass wir mit gen\u00fcgend gro\u00dfen Studien alle diese Muster identifizieren k\u00f6nnen, um Diagnose und Behandlung zu optimieren\u201c, sagt Dr. Peter Campbell, Mitglied des Lenkungsausschusses, vom Wellcome Sanger Institute in Gro\u00dfbritannien.<\/p>\n\n\n\n<p>Mit Hilfe einer Methode der &#8216;Kohlenstoffdatierung&#8217; entdeckten die Forscher \u2013 unter Beteiligung von Dr. Moritz Gerstung und seiner Gruppe vom Europ\u00e4ischen Bioinformatik-Institut (EMBL-EBI) in Hinxton, Gro\u00dfbritannien \u2013, dass es m\u00f6glich ist, Mutationen im Genom zu identifizieren, die Jahre oder manchmal sogar Jahrzehnte vor dem Auftreten des Tumors aufgetreten sind \u2013 was theoretisch eine neue M\u00f6glichkeit zur Krebsfr\u00fcherkennung werden k\u00f6nnte.&nbsp;&nbsp;<\/p>\n\n\n<div\n  class=\"vf-embed vf-embed--custom-ratio\"\n\n  style=\"--vf-embed-max-width: 100%;\n    --vf-embed-custom-ratio-x: 640;\n    --vf-embed-custom-ratio-y: 360;\"><iframe loading=\"lazy\" width=\"640\" height=\"360\" src=\"https:\/\/www.youtube.com\/embed\/Tug_vYiZnLI\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u201eWir haben gelernt, dass Krebs der Endpunkt eines lebenslangen Evolutionsprozesses ist, der unsere Zellen antreibt. Dieser Prozess wird durch Mutationen im Genom der Zellen angetrieben. Diese Mutationen treten im Laufe des Alters auf. Normalerweise haben diese Mutationen keine Folgen, aber manchmal k\u00f6nnen die Folgen dramatisch sein\u201c, sagt Gerstung. \u201eDieser Prozess kulminiert normalerweise in den Jahrzehnten vor der Krebsdiagnose, aber in einigen F\u00e4llen konnten wir Ver\u00e4nderungen feststellen, die so alt sind wie der Patient.\u201c<\/p>\n\n\n\n<p>Tumorarten k\u00f6nnen durch die Untersuchung der Muster genetischer Ver\u00e4nderungen im gesamten Genom genau identifiziert werden. Dies hat das Potenzial, die Diagnose von Krebserkrankungen eines Patienten zu erleichtern, deren Art durch herk\u00f6mmliche klinische Tests nicht bestimmt werden konnte. Die Kenntnis des genauen Tumortyps k\u00f6nnte auch dazu beitragen, die Behandlung auf bestimmte Patienten zuzuschneiden.<\/p>\n\n\n\n<p>\u201eDie Ergebnisse des Pan-Krebs-Projekts werden Patienten, die bereits an Krebs erkrankt sind, in dem Ma\u00dfe helfen, dass wir jetzt eine viel bessere molekulare Erkl\u00e4rung daf\u00fcr haben, was ihren Krebs antreiben k\u00f6nnte. So haben wir jetzt ein besseres Panorama, welche Mutationen wahrscheinlich ihre Krankheit verursachen. Und wenn wir wissen, was die Krankheit verursacht, haben wir eine bessere Chance, sie zu behandeln\u201c, sagt Joachim Weischenfeldt, Gruppenleiter am Biotech Research &amp; Innovation Centre in Kopenhagen.<\/p>\n\n\n\n<p>Zus\u00e4tzlich zu den bereits gemachten Entdeckungen stattet das Pan-Cancer-Projekt die Wissenschaftler mit einer umfassenden Ressource f\u00fcr die Krebsgenomforschung aus, einschlie\u00dflich der Rohdaten zur Genomsequenzierung, Software f\u00fcr die Krebsgenomanalyse und mehrere interaktive Websites, die verschiedene Aspekte der Pan-Krebs-Projektdaten untersuchen. \u201eWir haben eine Ressource f\u00fcr die wissenschaftliche Gemeinschaft eingerichtet, um die Krebsforschung voranzutreiben\u201c, sagt Jan Korbel.<\/p>\n\n\n\n<div\n  class=\"vf-box vf-box--inlay\">\n\n  <h3 class=\"vf-box__heading\">Links<\/h3>\n  <p class=\"vf-box__text\"><a href=\"http:\/\/www.embl.de\/pancancer\">EMBL Pan-Cancer\u00a0landing\u00a0page<\/a><br \/><a href=\"http:\/\/www.embl.org\/pancancer\/faq\">H\u00e4ufig gestellte Fragen zum Pan-Cancer Projekt (Englisch)<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>EMBL co-leads most comprehensive study of genetic causes of cancer<\/p>\n","protected":false},"author":71,"featured_media":18351,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[38,537,36,664,468,43,420,1008,989,1748,653],"embl_taxonomy":[],"class_list":["post-18355","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cancer","tag-dna","tag-embl-ebi","tag-genome","tag-gerstung","tag-heidelberg","tag-korbel","tag-mutation","tag-pan-cancer","tag-press-release","tag-tumour"],"acf":{"article_intro":"<p>EMBL co-leads most comprehensive study of genetic causes of cancer<\/p>\n","related_links":false,"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53","show_featured_image":false,"in_this_article":false,"youtube_url":"","mp4_url":"","video_caption":"","translations":[{"translation_language":"German","translation_anchor":"#de"}],"press_contact":"EMBL Generic","field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"source_article":false,"article_translations":false,"languages":""},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - 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