{"id":18349,"date":"2020-02-05T19:00:01","date_gmt":"2020-02-05T18:00:01","guid":{"rendered":"https:\/\/news.embl.de\/?p=18349"},"modified":"2024-03-22T11:21:37","modified_gmt":"2024-03-22T10:21:37","slug":"pan-cancer-molecular-clock","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/","title":{"rendered":"Finding genetic cancer risks"},"content":{"rendered":"\n

As part of the Pan-Cancer project, EMBL scientists have examined whole patient and cancer genomes in the search for genetic factors that influence cancer development. Their goal was to characterise and study heritable, or germline, genetic variation in genomes of cancer patients. Germline variants are present in every single cell of our body. By contrast, somatic mutations occur in individual body cells during an organism\u2019s lifetime and only affect the tissue that is derived from that cell. They can be driven by external factors like UV light or tobacco smoking. \u201cThe main finding of our study is that a person\u2019s genetic background can influence the changes we see in the genome of their cancer cells,\u201d says Sebastian Waszak; a postdoctoral fellow in the Korbel group at the time the research began.<\/p>\n\n\n

\n

The Pan-Cancer project<\/h2>\n

The Pan-Cancer Analysis of Whole Genomes project<\/a> is a collaboration involving more than 1300 scientists and clinicians from 37 countries. It involved analysis of more than 2600 genomes of 38 different tumour types, creating a huge resource of primary cancer genomes. This was the starting point for 16 working groups to study multiple aspects of cancer development, causation, progression, and classification.<\/p>\n

<\/p><\/div>\n\n\n\n

A clock-like mutational process<\/h2>\n\n\n\n

\u201cCancer is a disease of the somatic genome, caused by mutations that arise during our lifetime,\u201d says EMBL group leader Jan Korbel. \u201cBut in a certain number of patients, at least 5 to 10%, the reason for cancer is due to inherited mutations. In our study we identified several genetic factors that promote the somatic evolution of cancer cells.\u201d<\/p>\n\n\n\n

The group identified germline mutations in the gene MBD4<\/em> as a driver for an overabundance of somatic mutations in cancer genomes. MBD4<\/em> influences a mutational process that occurs naturally during ageing and is described as clock-like, because of the rhythm with which somatic mutations occur during our lifetime. In the presence of a mutated MBD4<\/em> gene, the clock-like mutational process runs at a much faster pace.<\/p>\n\n\n\n

Finding germline variants that influence cancer development is key for future medical applications. \u201cOur methodology can be used to identify genetic factors that increase the pace at which somatic mutations are acquired,\u201d says Sebastian Waszak. In the future, patients with an identified genetic risk could be counselled and offered regular screenings so that a pre-cancerous lesion is discovered as early as possible.<\/p>\n\n\n\n

Organisation and creativity<\/h2>\n\n\n\n

The working group responsible for this segment of the main Pan-Cancer paper included as many as 100 scientists. \u201cWe were very excited to understand the influence of genetic factors on cancer development,\u201d says Sebastian Waszak. \u201cThis was a project born out of curiosity and everybody contributed lots of resources to it. It was also an organisational challenge.\u201d Weekly teleconferences were held from EMBL to coordinate interests and roles, to discuss results, and to organise workshops.<\/p>\n\n\n\n

\u201cThere are many open questions when it comes to understanding cancer risks,\u201d says Sebastian Waszak. \u201cPan-Cancer has enabled us to study the early steps of cancer development from a novel perspective.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.<\/p>\n","protected":false},"author":69,"featured_media":18351,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[38,664,43,420,989,653],"embl_taxonomy":[],"class_list":["post-18349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cancer","tag-genome","tag-heidelberg","tag-korbel","tag-pan-cancer","tag-tumour"],"acf":{"article_intro":"

EMBL scientists describe how our genetic background influences cancer development<\/p>\n","related_links":[{"link_description":"Pan-Cancer landing page","link_url":"www.embl.de\/pancancer"},{"link_description":"Frequently Asked Questions on the Pan-Cancer project","link_url":"http:\/\/www.embl.org\/pancancer\/faq"},{"link_description":"Research highlight: Scientists identify new genetic drivers of cancer","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-cancer-drivers"},{"link_description":"Research highlight: Protecting data in the cloud","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-protecting-data"},{"link_description":"Research highlight: Studying DNA rearrangement to understand cancer","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-structural-variations"},{"link_description":"Research highlight: Rapid and safe analysis of thousands of human genomes in the cloud","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-butler\/"},{"link_description":"Research highlight: Cancer mutations occur decades before diagnosis","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-evolutionary-history"},{"link_description":"Research highlight: Chromothripsis in human cancer","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-chromosome-shattering"},{"link_description":"Research highlight: Characterising RNA alterations in cancer","link_url":"https:\/\/news.embl.de\/SCIENCE\/pan-cancer-rna-alterations"}],"article_sources":[{"source_description":"

The ICGC\/TCGA Pan-Cancer Analysis of Whole Genomes Consortium: Pan-cancer analysis of whole genomes; Nature<\/em>, 5 February 2020; DOI:\u00a010.1038\/s41586-020-1969-6<\/p>\n","source_link_url":"https:\/\/doi.org\/10.1038\/s41586-020-1969-6"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"\nFinding genetic cancer risks | EMBL<\/title>\n<meta name=\"description\" content=\"Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Finding genetic cancer risks | EMBL\" \/>\n<meta property=\"og:description\" content=\"Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-05T18:00:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T10:21:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Fabian Oswald\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabian Oswald\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\"},\"author\":{\"name\":\"Fabian Oswald\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/48be706f1efcc54679ef766039c416ae\"},\"headline\":\"Finding genetic cancer risks\",\"datePublished\":\"2020-02-05T18:00:01+00:00\",\"dateModified\":\"2024-03-22T10:21:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\"},\"wordCount\":496,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg\",\"keywords\":[\"cancer\",\"genome\",\"heidelberg\",\"korbel\",\"pan cancer\",\"tumour\"],\"articleSection\":[\"Science\",\"Science & Technology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\",\"url\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\",\"name\":\"Finding genetic cancer risks | EMBL\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg\",\"datePublished\":\"2020-02-05T18:00:01+00:00\",\"dateModified\":\"2024-03-22T10:21:37+00:00\",\"description\":\"Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/pan-cancer-molecular-clock\/#primaryimage\",\"url\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg\",\"contentUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/02\/pancancer-ib.jpg\",\"width\":620,\"height\":425,\"caption\":\"The Pan-Cancer project showed that there is a molecular clock in our cells. 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