{"id":18248,"date":"2020-02-04T09:00:25","date_gmt":"2020-02-04T08:00:25","guid":{"rendered":"https:\/\/news.embl.de\/?p=18248"},"modified":"2024-03-22T11:21:11","modified_gmt":"2024-03-22T10:21:11","slug":"potw2005","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/","title":{"rendered":"From cosmetics to blood cells"},"content":{"rendered":"\n<p>Every day, our body produces billions of blood cells that help keep our organs oxygenated and fight against infections. Blood stem cells \u2013 also called haematopoietic stem cells \u2013 divide continuously and sustain the mass production of all blood cell types.<\/p>\n\n\n\n<p>Morgan Oatley and her colleagues in <a href=\"https:\/\/www.embl.it\/research\/unit\/lancrin\/\">Christophe Lancrin\u2019s group<\/a> at EMBL Rome investigated how haematopoietic stem cells emerge from the endothelium in developing mouse embryos. <a href=\"https:\/\/www.embl.it\/research\/unit\/lancrin\/\">They found out that the expression of a specific marker<\/a> \u2013 the protein CD44 \u2013 regulates which embryonic cells become blood stem cells.<\/p>\n\n\n\n<p>Embryos express CD44 on the cell surface, where it binds hyaluronic acid \u2013 a key ingredient of anti-aging products in the cosmetic industry. While hyaluronic acid might make your skin look better, it turns out that it also interacts with CD44 to promote the formation of haematopoietic stem cells in developing embryos.<\/p>\n\n\n\n<p>In this confocal image, CD44 coats some cells (green) in a cross-section of an embryonic artery. Magenta shows the expression of a protein in cells that line the interior surface of blood vessels, while nuclei appear in blue, coloured with a fluorescent dye (DAPI).<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image\"><a href=\"https:\/\/news.embl.de\/wp-content\/uploads\/2020\/01\/potw2005_highres.jpg\"><img loading=\"lazy\" decoding=\"async\" width=\"990\" height=\"1024\" class=\"vf-figure__image\" src=\"https:\/\/news.embl.de\/wp-content\/uploads\/2020\/01\/potw2005_highres-990x1024.jpg\" alt=\"\" class=\"wp-image-18249\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/01\/potw2005_highres.jpg 990w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/01\/potw2005_highres-290x300.jpg 290w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/01\/potw2005_highres-768x794.jpg 768w\" sizes=\"auto, (max-width: 990px) 100vw, 990px\" \/><\/a><figcaption class=\"vf-figure__caption\">Credit: Morgan Oatley\/EMBL<\/figcaption><\/figure>\n\n\n\n<p><span style=\"font-weight: 400;\">If you have a stunning picture of your science, your lab or your site, you can submit it <\/span><a href=\"mailto:mathias.jaeger@embl.de\"><span style=\"font-weight: 400;\">here<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Morgan Oatley and her colleagues in Christophe Lancrin\u2019s group investigated how haematopoietic stem cells emerge from the endothelium in developing mouse embryos.<\/p>\n","protected":false},"author":71,"featured_media":18250,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[6,17591],"tags":[523,616,514,118],"embl_taxonomy":[19317],"class_list":["post-18248","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-picture-of-the-week","category-science-technology","tag-lancrin","tag-protein","tag-rome","tag-stem-cell","embl_taxonomy-lancrin-group"],"acf":{"article_intro":"","related_links":false,"article_sources":[{"source_description":"<p>Morgan Oatley et al. Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition. Nature Communications, published 29 January 2020.<\/p>\n","source_link_url":"https:\/\/doi.org\/10.1038\/s41467-019-14171-5"}],"featured":false,"color":"#007B53","vf_locked":false},"embl_taxonomy_terms":[{"uuid":"a:3:{i:0;s:36:\"302cfdf7-365b-462a-be65-82c7b783ebf7\";i:1;s:36:\"a6e35bb0-c32d-4c9b-aadb-a19b6c7b060f\";i:2;s:36:\"23fe3a4b-fdf2-4d1a-a2ce-8bf78ccf334f\";}","parents":[],"name":["Lancrin Group"],"slug":"lancrin-group","description":"What &gt; Epigenetics and neurobiology &gt; Lancrin Group","deprecated":true}],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>From cosmetics to blood cells | EMBL<\/title>\n<meta name=\"description\" content=\"Christophe Lancrin and his group at EMBL Rome try to understand more about the formation of blood stem cells\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"From cosmetics to blood cells | EMBL\" \/>\n<meta property=\"og:description\" content=\"Christophe Lancrin and his group at EMBL Rome try to understand more about the formation of blood stem cells\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-04T08:00:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T10:21:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/01\/potw2005_preview.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Mathias J\u00e4ger\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Mathias J\u00e4ger\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/\"},\"author\":{\"name\":\"Mathias J\u00e4ger\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/63a0ca26daa6707834de41dfddfc6a42\"},\"headline\":\"From cosmetics to blood cells\",\"datePublished\":\"2020-02-04T08:00:25+00:00\",\"dateModified\":\"2024-03-22T10:21:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/\"},\"wordCount\":209,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/picture-of-the-week\/potw2005\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2020\/01\/potw2005_preview.jpg\",\"keywords\":[\"lancrin\",\"protein\",\"rome\",\"stem cell\"],\"articleSection\":[\"Picture of the week\",\"Science &amp; 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