{"id":17736,"date":"2019-11-18T17:06:56","date_gmt":"2019-11-18T16:06:56","guid":{"rendered":"https:\/\/news.embl.de\/?p=17736"},"modified":"2024-03-22T10:52:27","modified_gmt":"2024-03-22T09:52:27","slug":"photo-micropatterning-advances-structural-cell-biology","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/","title":{"rendered":"Photo-micropatterning advances structural cell biology"},"content":{"rendered":"\n<p>Scientists in the Mahamid group, together with the Th\u00e9ry lab at CytomorphoLab, France, have developed a new technique that allows spatially controlled cell adhesion and the manipulation of cell shapes on cryo-electron microscopy grids. The photo-micropatterning technique \u2013 hailed as an important advance by the research community \u2013 is presented in a paper published in <em>Nature Methods <\/em>on 18 November.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The pipeline<\/h2>\n\n\n\n<p>Cryo-electron tomography is a technique that allows scientists to produce three-dimensional snapshots of a cell, revealing the intracellular molecular landscape at high resolution. Specimens are prepared by growing cells on a thin electron microscopy support grid, rapidly freezing the grid, and then using a focused ion beam in a scanning electron microscope to ablate \u2013 or blast away \u2013 surplus material, to produce a very thin section called a lamella.<\/p>\n\n\n\n<p>However, only cells that are positioned in the centre of a grid square are available for this thinning process, so ensuring there are enough cells to work with is challenging. According to Mauricio Toro-Nahuelpan \u2013 a postdoc in the Mahamid group, and the paper\u2019s first author \u2013 in a typical session five to nine cells can be processed, but this number is limited by the availability of cells properly positioned at the grid centre. Using the micropatterning technique, this bottleneck is removed, as the position of cells on the grid can be controlled with a high degree of spatial accuracy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Micropatterning: how it works<\/h2>\n\n\n\n<p>Micropatterning of the grids to control the location of cells is achieved by coating standard grids with a passivation layer of polyethylene glycol \u2013 essentially, a layer that repels biological material, including cells and proteins. After controlled ablation of the biorepellent area using a UV laser, a micropattern is generated. This biorepellent-free area can be coated with proteins that promote cell adherence at desired locations. Group leader and corresponding author Julia Mahamid explains: \u201cBy controlling spatially where you have repelling material versus non-repelling material, you can create areas where proteins and cells will preferentially sit.\u201d<\/p>\n\n\n\n<p>The scientists have demonstrated the technique successfully on a variety of materials, including silicon dioxide, gold and amorphous carbon films. Such films are overlaid on either gold or titanium metal meshes, i.e. grids.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A tool for exploring cell biomechanics<\/h2>\n\n\n\n<p>As well as controlling the position of cells on a grid, micropatterning can be used to manipulate the shape of cells, to study their mechanical behaviour. What\u2019s more, numerous different patterns can be generated on the same grid, for direct comparison of different cellular architectures.<\/p>\n\n\n\n<p>\u201cWe can pattern very complex shapes, generating very specific configurations of the cell architecture \u2013 controlling the cytoskeleton, and intracellular positions of organelles such as the nucleus, Golgi apparatus, and centrosome\u201d says Toro-Nahuelpan. \u201cThis opens a new window to explore existing and novel questions in biomechanics, with a resolution that is achievable only via cryo-electron microscopy.\u201d<\/p>\n\n\n\n<p>\u201cUnderstanding the three-dimensional architecture can help to explain the collective behaviours that give rise to new mechanical properties,\u201d adds Mahamid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Connecting structural and cell biology<\/h2>\n\n\n\n<p>The micropatterning technique is a technical advance with broad implications for cell biology. \u201cIt will help to streamline the cryo-electron microscopy pipeline, and facilitate automation of the process,\u201d Toro-Nahuelpan says. It\u2019s also perceived by the research community as a significant bridge between structural and cell biology. There are currently only a handful of labs with the expertise and technology to do cellular cryo-electron tomography, but this latest development is a move towards making this a routine method in the future.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new technique in cryo-EM<\/p>\n","protected":false},"author":68,"featured_media":17759,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[64,712,718,542,953,539,35],"embl_taxonomy":[],"class_list":["post-17736","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-cell-biology","tag-cryo-electron-tomography","tag-cryo-em","tag-mahamid","tag-photo-micropatterning","tag-research-highlight","tag-structural-biology"],"acf":{"article_intro":"<p>EMBL scientists develop an important new technique in cryo-electron microscopy<\/p>\n","related_links":[{"link_description":"EMBO Workshop: In situ Structural Biology \u2013 From Cryo-EM to Integrative Modelling (6\u20138 December 2020)","link_url":"https:\/\/www.embl.de\/training\/events\/2020\/ISS20-01\/index.html"}],"article_sources":[{"source_description":"<p>Toro-Nahuelpan M <i>et al. <\/i>Tailoring cryo-electron microscopy grids by photo-micropatterning for in-cell structural studies. <i>Nature Methods<\/i>. Published online 18 November 2019. DOI: 10.1038\/s41592-019-0630-5<\/p>\n","source_link_url":"https:\/\/www.nature.com\/articles\/s41592-019-0630-5"}],"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Photo-micropatterning advances structural cell biology | EMBL<\/title>\n<meta name=\"description\" content=\"A new technique allows spatially controlled cell adhesion and the manipulation of cell shapes on cryo-electron microscopy grids.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Photo-micropatterning advances structural cell biology | EMBL\" \/>\n<meta property=\"og:description\" content=\"A new technique allows spatially controlled cell adhesion and the manipulation of cell shapes on cryo-electron microscopy grids.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-11-18T16:06:56+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T09:52:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2019\/11\/Illustration_2c.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"620\" \/>\n\t<meta property=\"og:image:height\" content=\"376\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cella Carr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Cella Carr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/\"},\"author\":{\"name\":\"Cella Carr\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/3bb76de286246270a71cf08b368e0594\"},\"headline\":\"Photo-micropatterning advances structural cell biology\",\"datePublished\":\"2019-11-18T16:06:56+00:00\",\"dateModified\":\"2024-03-22T09:52:27+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/\"},\"wordCount\":577,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/photo-micropatterning-advances-structural-cell-biology\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2019\/11\/Illustration_2c.jpg\",\"keywords\":[\"cell biology\",\"cryo-electron tomography\",\"cryo-em\",\"mahamid\",\"photo-micropatterning\",\"research highlight\",\"structural biology\"],\"articleSection\":[\"Science\",\"Science &amp; 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