{"id":15443,"date":"2019-03-08T12:05:52","date_gmt":"2019-03-08T11:05:52","guid":{"rendered":"https:\/\/news.embl.de\/?p=15443"},"modified":"2024-03-22T11:19:31","modified_gmt":"2024-03-22T10:19:31","slug":"welcome-sagar-bhogaraju","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/","title":{"rendered":"Welcome: Sagar Bhogaraju"},"content":{"rendered":"\n<p>With a diverse research background in biochemistry and structural biology, <a href=\"https:\/\/www.embl.fr\/research\/unit\/bhogaraju\/index.html\">new EMBL group<\/a> leader Sagar Bhogaraju is on a mission to gain a molecular understanding of a family of proteins known as melanoma antigens.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What is the focus of your research?<\/h3>\n\n\n\n<p>In my lab we\u2019re trying to understand a family of proteins known as melanoma antigens (MAGEs); in other words, proteins expressed by certain tumours, which can trigger an immune response. They\u2019re called melanoma antigens because they were first discovered in a melanoma patient. That was one of the first tumour antigens discovered in humans, and since then around 50 other similar proteins have been discovered. Because these antigens elicit an immune response, it\u2019s possible to use them to develop vaccines for certain types of cancer. Most of the research is focused in this area, and there are numerous clinical trials currently in progress. What is less well known, however, is what roles these proteins have in cells. Recent papers have reported that these proteins can be oncogenic; in other words, they\u2019re not just markers of tumours but actually have a role in the development of many different cancer types, although it\u2019s not understood how. My lab will be focusing on gaining a molecular understanding of the cellular role of these proteins.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">How did you become interested in this topic?<\/h3>\n\n\n\n<p>It started with my interest in the protein ubiquitin originally. During my PhD I was working on a very different topic, but my supervisor, Esben Lorentzen, encouraged me to consider different topics and learn different techniques for my postdoc. I consider that one of the best pieces of advice I received. At the end of my PhD I went to conferences and heard interesting talks about ubiquitin, after which I became curious about it. Ubiquitin is the first protein molecule in the cell that was discovered to be joined \u2013 or conjugated \u2013 to other proteins. I moved to Ivan Dikic\u2019s lab for my postdoc, where I worked with fellow ubiquitin enthusiasts and learned much of what I know about cell signalling in the context of ubiquitin.<\/p>\n\n\n\n<p>Even though it\u2019s now more than thirty years since the discovery of ubiquitin, there are still surprising findings emerging and there\u2019s a lot more to be discovered. The melanoma antigens that I\u2019m working on now are a family of proteins whose role is definitely linked to ubiquitin, because they seem to be involved in activating enzymes that conjugate ubiquitin to other proteins. It\u2019s not understood how this activation happens, and under what circumstances. These are all interesting questions that link the clinical side of things with my interest in ubiquitin. The fact that the relation between MAGEs and ubiquitin signalling is not completely understood is attractive to me. I like these problems!<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What were the main challenges in the transition from postdoc to group leader?<\/h3>\n\n\n\n<p>I would say the transition period itself was challenging. During this time, you\u2019re involved in setting up the lab. Of course, it\u2019s very important to design the lab the way you want it to be, but it takes your focus away from science briefly and I\u2019m not used to that. For the past ten years of my career, I\u2019ve thought only of scientific projects and not many other factors. To continuously have to think about these organisational matters is a challenge, although things are quite streamlined at EMBL. I think it\u2019s important to realise that it\u2019s just a passing phase, and as soon as you have some PhD students and postdocs in the lab the science will take over.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">As you build your group, what traits and skills are you looking for?<\/h3>\n\n\n\n<p>EMBL already attracts amazing talent. My criteria are simple. I\u2019m looking for people who are highly motivated and willing to learn, and it would be wonderful if they could also bring in their own ideas. I like to be challenged, I like discussions, and I like new ideas. Having people with this kind of attitude will create a dynamic atmosphere in the lab, where the scientific discussions are very interesting and fun to be involved in.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What\u2019s your philosophy for running your lab?<\/h3>\n\n\n\n<p>I like to let the science run the lab and drive every decision I make. Be it assigning a project, collaborating with an external group, or bringing in a new technique to the lab, people will have confidence in your decisions if your decisions have their basis in science.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What\u2019s special about working at EMBL?<\/h3>\n\n\n\n<p>I mentioned earlier the talent EMBL attracts. I find it quite amazing to work with these extraordinary people right next to me, to have lunch with them, to have discussions, and talk about the latest technologies and developments. It\u2019s an enriching experience. Also, the support system that EMBL has in terms of HR makes your life relatively easy and lets you focus on what\u2019s most important, which is the science. So far, it\u2019s been a wonderful experience to work at EMBL.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What inspires you?<\/h3>\n\n\n\n<p>For me, it\u2019s all about reading good scientific literature. That keeps me motivated. I try to read a lot, and not only from my own field. Thinking about some great papers from the point of view of the authors makes it very interesting for me. How could they have thought of this? What would they have felt when they discovered this? Sometimes I read these old papers about the original discovery of a concept or some biological pathway. Sixty or seventy years ago, without the technology we have today, people were still able to make incredible discoveries, and reading about the history of these discoveries is fascinating for me.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What advice would you give to young scientists beginning their research careers?<\/h3>\n\n\n\n<p>It\u2019s good to appreciate all kinds of science. Let\u2019s say you\u2019re a master\u2019s student or an early PhD student: you get into a topic and that probably becomes your favourite topic (or you don\u2019t have time to think about other topics!). But it\u2019s good to appreciate other techniques, other kinds of research. I think that has helped me, because I changed my line of research from PhD to postdoc, and from postdoc to group leader. This keeps me on the edge. This approach could be adopted by more people, I think; it could turn out to be very rewarding in the end. There\u2019s nothing wrong in being focused on one thing, but it\u2019s good to attend a talk on a different subject, or maybe once in a while attend a conference that doesn\u2019t only focus on your research topic. Keep an open mind.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New group leader at EMBL Grenoble is investigating the cellular role of melanoma antigens<\/p>\n","protected":false},"author":68,"featured_media":15444,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[789,37,35,295],"embl_taxonomy":[],"class_list":["post-15443","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-bhogaraju","tag-grenoble","tag-structural-biology","tag-welcome"],"acf":{"article_intro":"<p>New group leader at EMBL Grenoble is investigating the cellular role of melanoma antigens<\/p>\n","related_links":[{"link_description":"Bhogaraju group","link_url":"https:\/\/www.embl.fr\/research\/unit\/bhogaraju\/index.html"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Welcome: Sagar Bhogaraju | EMBL<\/title>\n<meta name=\"description\" content=\"Sagar Bhogaraju, new group leader at EMBL Grenoble, is investigating the cellular role of melanoma antigens.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Welcome: Sagar Bhogaraju | EMBL\" \/>\n<meta property=\"og:description\" content=\"Sagar Bhogaraju, new group leader at EMBL Grenoble, is investigating the cellular role of melanoma antigens.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/\" \/>\n<meta property=\"og:site_name\" content=\"EMBL\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/embl.org\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-08T11:05:52+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-22T10:19:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2019\/03\/SagarBhogaraju_portrait.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"853\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Cella Carr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@embl\" \/>\n<meta name=\"twitter:site\" content=\"@embl\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Cella Carr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"NewsArticle\",\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/\"},\"author\":{\"name\":\"Cella Carr\",\"@id\":\"https:\/\/www.embl.org\/news\/#\/schema\/person\/3bb76de286246270a71cf08b368e0594\"},\"headline\":\"Welcome: Sagar Bhogaraju\",\"datePublished\":\"2019-03-08T11:05:52+00:00\",\"dateModified\":\"2024-03-22T10:19:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/\"},\"wordCount\":1122,\"publisher\":{\"@id\":\"https:\/\/www.embl.org\/news\/#organization\"},\"image\":{\"@id\":\"https:\/\/www.embl.org\/news\/science\/welcome-sagar-bhogaraju\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2019\/03\/SagarBhogaraju_portrait.jpg\",\"keywords\":[\"bhogaraju\",\"grenoble\",\"structural biology\",\"welcome\"],\"articleSection\":[\"Science\",\"Science &amp; 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