{"id":14378,"date":"2018-10-04T16:19:15","date_gmt":"2018-10-04T14:19:15","guid":{"rendered":"https:\/\/news.embl.de\/?p=14378"},"modified":"2024-03-22T11:22:57","modified_gmt":"2024-03-22T10:22:57","slug":"lola-ledesma-embl-in-spain","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/alumni\/lola-ledesma-embl-in-spain\/","title":{"rendered":"EMBL in Spain: Lola Ledesma"},"content":{"rendered":"\n

More than 100 EMBL alumni and researchers in Spain came together on 8 October at the Centro de Biolog\u00eda Molecular Severo Ochoa (CBMSO) in Madrid<\/a> to build new networks and share ideas. EMBL alumna, Lola Ledesma<\/a>, co-organised this event alongside alumni Jose Mar\u00eda Almendral<\/a> and Luis Men\u00e9ndez-Arias<\/a>. In the lead up to this event, Lola spoke about her current research at CBMSO and the importance of doing research abroad.<\/p>\n\n\n\n

What did you work on during your postdoc?<\/h3>\n\n\n\n

I joined EMBL in January 1996 as a postdoctoral fellow in the lab of Carlos Dotti. I worked there for 5 years, characterising specialised regions in the membranes of neurons. These regions \u2013 known as lipid rafts \u2013 contain lipids [fats] and signalling receptor proteins. We showed that these lipid rafts are crucial for the breakdown of certain proteins within the cell. For example, when the fats that make up a lipid raft change, the production of a small protein important in Alzheimer\u2019s disease \u2013 known as amyloid beta \u2013 is altered. To study this, I learnt how to grow embryonic neurons in a dish, until they were mature and functional. We even used them to study neurons as they aged!<\/p>\n\n\n\n

What does your work involve today?<\/h3>\n\n\n\n

My work at EMBL has really dictated my current research. My group focuses on the lipids in brain cells. In particular, I\u2019m trying to understand the role of two different lipids \u2013 sphingomyelin and cholesterol \u2013 in both healthy and diseased neurons. To do this, my research group uses mouse models which mimic certain genetic disorders that affect human brains. In these diseases, the normal storage of fats in the brain is altered and the levels of either sphingomyelin or cholesterol rise inside the cells. This causes serious learning and behavioural disabilities.<\/p>\n\n\n\n

\"EMBL<\/a>
EMBL in Spain participants. PHOTO: Jose Antonio P\u00e9rez\/CBMSO<\/figcaption><\/figure><\/div>\n\n\n\n

What did you learn at EMBL?<\/h3>\n\n\n\n

Being at EMBL was an extraordinary experience, both professionally and personally. It\u2019s a paradise for science. This is partly because of the many resources which are available, but also because the people at EMBL are so passionate about their science. Group leaders dare to take on risky and creative projects and there\u2019s an excitement that comes with that. This is something that I\u2019ve tried to keep in mind since leaving EMBL.<\/p>\n\n\n\n

At this event we will continue to build these networks and keep in touch with old friends<\/p><\/blockquote>\n\n\n\n

What are your aims for the EMBL in Spain event?<\/h3>\n\n\n\n

I think that, for all the organisers of the EMBL in Spain event, EMBL was a place to build networks and make friends. At this event we will continue to build these networks and keep in touch with old friends. We also want young researchers in Spain to know more about the opportunities that EMBL can offer them. These scientists are looking for places to start or continue their careers and we want them to know that EMBL is a great place for them to do this.<\/p>\n\n\n\n

We\u2019ve invited EMBL researchers and alumni from all over Spain to speak about their different research topics. We have presentations about brain ageing, development, gene therapy, bioinformatics and structural biology. But it\u2019s also important to understand more about other career paths. One of our speakers, who was a postdoc at EMBL, will tell us about how she moved out of academia to work in industry.<\/p>\n\n\n\n

What\u2019s your advice to early-stage researchers?<\/h3>\n\n\n\n

I think that everyone at the start of their scientific career is passionate about their work. But it\u2019s important for this passion to continue. Sometimes you might need to take time off, for example if you have children, but this doesn\u2019t mean you have to give up science. It is more difficult but the two things are not incompatible. Try to find ways to come back with the same passion and energy as before.<\/p>\n\n\n\n

As well as this, I think it\u2019s important to go abroad to do research. Wherever you go, you\u2019ll learn different techniques and develop scientifically. It\u2019ll also open your mind from a personal point of view. It will help you build your network and understand other people\u2019s attitudes. After I was in Heidelberg, I was in Italy and in Belgium for several years before coming back to Spain. I really treasure that experience.<\/p>\n","protected":false},"excerpt":{"rendered":"

EMBL alumni and researchers working throughout Spain met in Madrid<\/p>\n","protected":false},"author":59,"featured_media":14379,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5,17595],"tags":[80,59,92,67],"embl_taxonomy":[],"class_list":["post-14378","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alumni","category-connections","tag-alumni","tag-careers","tag-event","tag-neurobiology"],"acf":{"article_intro":"

EMBL alumni and researchers working throughout Spain met in Madrid<\/p>\n","related_links":[{"link_description":"EMBL in Spain - Information about the event","link_url":"https:\/\/www.embl.de\/aboutus\/alumni\/events-networks\/local-chapters\/spain\/84_madrid_2018\/index.html"},{"link_description":"EMBL Alumni Relations","link_url":"https:\/\/www.embl.de\/aboutus\/alumni\/index.html"}],"article_sources":false,"vf_locked":false,"featured":false,"color":"#007B53"},"embl_taxonomy_terms":[],"yoast_head":"\nEMBL in Spain: Lola Ledesma | EMBL<\/title>\n<meta name=\"description\" content=\"Lola Ledesma, EMBL alumna and co-organiser of the EMBL in Spain event chats about her current research and the importance of doing research abroad.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/alumni\/lola-ledesma-embl-in-spain\/\" \/>\n<meta property=\"og:locale\" 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