{"id":14277,"date":"2018-09-17T17:00:36","date_gmt":"2018-09-17T15:00:36","guid":{"rendered":"https:\/\/news.embl.de\/?p=14277"},"modified":"2024-08-29T14:12:17","modified_gmt":"2024-08-29T12:12:17","slug":"solving-retromer-structure","status":"publish","type":"post","link":"https:\/\/www.embl.org\/news\/science\/solving-retromer-structure\/","title":{"rendered":"Solving the structure of retromer"},"content":{"rendered":"\n<p>Retromer is a molecular machine that sorts and packs cargo at the cell\u2019s logistics hub, the endosome. It ensures the safe and efficient transport of cellular cargo in all eukaryotes, from baker\u2019s yeast to humans.<\/p>\n\n\n\n<p>An international research team now publishes the full 3D structure of retromer. They used cryo-electron tomography to reveal the structure of the retromer complex assembled on a membrane, allowing a greater understanding of how this molecular machine works.<\/p>\n\n\n\n<p><em>(text continues below image)<\/em><\/p>\n\n\n\n<div class=\"wp-block-image wp-image-14280 size-full\"><figure class=\"vf-figure  | vf-figure--align vf-figure--align-centered  size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"217\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/09\/The-retromer-complex-red-yellow-and-green..jpg\" alt=\"\" class=\"wp-image-14280\" srcset=\"https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/09\/The-retromer-complex-red-yellow-and-green..jpg 500w, https:\/\/www.embl.org\/news\/wp-content\/uploads\/2018\/09\/The-retromer-complex-red-yellow-and-green.-300x130.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><figcaption class=\"vf-figure__caption\">The retromer complex (red, yellow and green) forms arch-like structures that reinforce tubular transport vesicles and provide a scaffold interacting with other modules of the sorting machinery, such as sorting nexin proteins (blue).<\/figcaption><\/figure><\/div>\n\n\n\n<p>To achieve this, researchers in John Briggs\u2019 group \u2013 formerly at EMBL and now at the Laboratory of Molecular Biology (LMB) \u2013 collaborated with scientists at the University of Queensland, the University of Cambridge, and the Max Planck Institute of Biochemistry. They publish their findings in Nature on 17 September 2018.<\/p>\n\n\n\n<p>The full structure of retromer, with its arches, scaffolds and curving membranes, shows how this protein machinery is assembled and gives important insights into its function. It also suggests how mutations in human patients could lead to retromer malfunction, known to lead to neurodegenerative diseases.<\/p>\n\n\n\n<p><em>For more information, see the LMB story or the press release by the University of Queensland.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Retromer\u2019s 3D structure improves understanding of cellular sorting and packaging<\/p>\n","protected":false},"author":16,"featured_media":14278,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2,17591],"tags":[348,712,539,710],"embl_taxonomy":[],"class_list":["post-14277","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science","category-science-technology","tag-briggs","tag-cryo-electron-tomography","tag-research-highlight","tag-retromer"],"acf":{"article_intro":"<p>Retromer\u2019s 3D structure improves understanding of cellular sorting and packaging<\/p>\n","related_links":[{"link_description":"","link_url":""},{"link_description":"","link_url":""}],"article_sources":[{"source_description":"<p>Kovtun, O., et al. Structure of the membrane-assembled retromer coat determined by cryo-electron tomography. <em>Nature<\/em>, 17 September 2018. DOI: 10.1038\/s41586-018-0526-z<\/p>\n","source_link_url":"https:\/\/doi.org\/10.1038\/s41586-018-0526-z"}],"vf_locked":false,"featured":false,"color":"#007B53","show_featured_image":false,"field_target_display":"embl","field_article_language":{"value":"english","label":"English"},"source_article":false,"in_this_article":false,"press_contact":"None","article_translations":false,"languages":""},"embl_taxonomy_terms":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Solving the structure of retromer | EMBL<\/title>\n<meta name=\"description\" content=\"EMBL scientists have revealed the 3D structure of retromer, which improves our understanding of cellular sorting and packaging.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.embl.org\/news\/science\/solving-retromer-structure\/\" 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